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10 Best Pain Relievers of 2026
Last updated on 02/02/2026
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1
Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count
Amazon Basic Care
Why we love it
Effective for arthritis pain relief.
Aspirin free and gluten free.
Child-resistant cap ensures safety.
Main Highlights
ACTIVE INGREDIENT: Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg active ingredient is acetaminophen 650 mg,. Compare to the active ingredient in Tylenol 8HR Arthritis Pain.
PURPOSE: Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg is a pain reliever and fever reducer that can be used for the temporary relief of minor pain of arthritis.
TEMPORARY PAIN RELIEF: This product may also be used to temporarily relieve other minor aches and pains due to: muscular aches, backache, premenstrual and menstrual cramps, the common cold, headache, toothache.
ASPIRIN FREE, GLUTEN FREE: Extended release caplets (capsule-shaped tablets) each provide 650 mg of acetaminophen, pain reliever and fever reducer, and contain no aspirin. Effective for minor arthritis pain. This product is gluten free.
PUSH & TURN CAP: The container has a child-resistant cap. This product is a pain reliever and fever reducer for adults. Under 18 years of age, ask a doctor.
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9.7
Exceptional
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9.7
Exceptional
Amazon Basic Care
Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count
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Why we love it
Effective for arthritis pain relief.
Aspirin free and gluten free.
Child-resistant cap ensures safety.
Main Highlights
ACTIVE INGREDIENT: Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg active ingredient is acetaminophen 650 mg,. Compare to the active ingredient in Tylenol 8HR Arthritis Pain.
PURPOSE: Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg is a pain reliever and fever reducer that can be used for the temporary relief of minor pain of arthritis.
TEMPORARY PAIN RELIEF: This product may also be used to temporarily relieve other minor aches and pains due to: muscular aches, backache, premenstrual and menstrual cramps, the common cold, headache, toothache.
ASPIRIN FREE, GLUTEN FREE: Extended release caplets (capsule-shaped tablets) each provide 650 mg of acetaminophen, pain reliever and fever reducer, and contain no aspirin. Effective for minor arthritis pain. This product is gluten free.
PUSH & TURN CAP: The container has a child-resistant cap. This product is a pain reliever and fever reducer for adults. Under 18 years of age, ask a doctor.
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Value for Money
2
Aleve Gelcaps with Easy Open Arthritis Cap, Naproxen Sodium, Medication for Arthritis Pain, 160 Count
Aleve
21% Off
Why we love it
Long-lasting pain relief effective.
Easy to open for all.
Reduces fever quickly and safely.
Main Highlights
Up to 12-Hours of Uninterrupted Pain Relief: Aleve Pain Reliever & Fever Reducer Gelcaps provide long-lasting arthritis pain relief, as well as relief from muscular aches, backache, menstrual cramps, headache, toothache, and the common cold
Easy Open Arthritis Cap: Specially designed arthritis bottle features an easy to open, cushionedcovered cap and contoured bottle for better control when your arthritis acts up. Package is not child-resistant
Fever Reducer: Temporarily reduces fever for adults and children aged 12 and up
Targeted Pain Relief: naproxen sodium relieves minor pain from arthritis
Effective Pain Reliever: In a study, proven as effective and longer lasting than a common Rx pain reliever. Ask a doctor if Aleve is right for you
Country of origin: India
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9.7
Exceptional
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9.7
Exceptional
Aleve
Aleve Gelcaps with Easy Open Arthritis Cap, Naproxen Sodium, Medication for Arthritis Pain, 160 Count
21% Off
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Why we love it
Long-lasting pain relief effective.
Easy to open for all.
Reduces fever quickly and safely.
Main Highlights
Up to 12-Hours of Uninterrupted Pain Relief: Aleve Pain Reliever & Fever Reducer Gelcaps provide long-lasting arthritis pain relief, as well as relief from muscular aches, backache, menstrual cramps, headache, toothache, and the common cold
Easy Open Arthritis Cap: Specially designed arthritis bottle features an easy to open, cushionedcovered cap and contoured bottle for better control when your arthritis acts up. Package is not child-resistant
Fever Reducer: Temporarily reduces fever for adults and children aged 12 and up
Targeted Pain Relief: naproxen sodium relieves minor pain from arthritis
Effective Pain Reliever: In a study, proven as effective and longer lasting than a common Rx pain reliever. Ask a doctor if Aleve is right for you
Country of origin: India
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3
Aleve Back & Muscle Pain Relief Naproxen Sodium Tablets, Pain Reliever & Fever Reducer, Medicine for Body , 250 Count
Aleve
7% Off
Why we love it
Long-lasting pain relief formula.
Reduces fever effectively.
Easy-to-swallow tablet size.
Main Highlights
Up to 12-Hours of Uninterrupted Pain Relief: Aleve Back & Muscle Pain Relief Tablets provide long-lasting back pain and muscle pain relief
Fever Reducer: Temporarily reduces fever for adults and children aged 12 and up
Targeted Pain Relief: Every tablet is made with 220 mg of naproxen sodium to help you take on muscle pain and provide back pain relief
Effective Pain Reliever: In a study, proven as effective and longer lasting than a common Rx pain reliever. Ask a doctor if Aleve is right for you
Comes in small, easy-to-swallow tablets; use as directed
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9.7
Exceptional
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9.7
Exceptional
Aleve
Aleve Back & Muscle Pain Relief Naproxen Sodium Tablets, Pain Reliever & Fever Reducer, Medicine for Body , 250 Count
7% Off
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Why we love it
Long-lasting pain relief formula.
Reduces fever effectively.
Easy-to-swallow tablet size.
Main Highlights
Up to 12-Hours of Uninterrupted Pain Relief: Aleve Back & Muscle Pain Relief Tablets provide long-lasting back pain and muscle pain relief
Fever Reducer: Temporarily reduces fever for adults and children aged 12 and up
Targeted Pain Relief: Every tablet is made with 220 mg of naproxen sodium to help you take on muscle pain and provide back pain relief
Effective Pain Reliever: In a study, proven as effective and longer lasting than a common Rx pain reliever. Ask a doctor if Aleve is right for you
Comes in small, easy-to-swallow tablets; use as directed
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4
Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes for Fast Release, Gentle on Stomach, 500 mg Per Gelcap, 100 Count OTC Medicine
Tylenol
25% Off
Why we love it
Fast relief from aches.
Gentle on the stomach.
Doctor recommended for pain.
Main Highlights
Fast-acting relief: Tylenol Extra Strength Rapid Release Gels feature 500 mg acetaminophen per gelcap to temporarily relieve minor aches and pains from headache, backache, arthritis, toothache, menstrual cramps, muscle aches, and fever; 100-count
Rapid-release technology: Laser-drilled holes in each gelcap release acetaminophen faster for extra strength pain relief; gelcaps are gentle on the stomach and suitable for adults and children 12 years and older
Multi-symptom support: Use as a fever reducer and to relieve headache, backache, muscle aches, arthritis pain, toothache, and joint discomfort; also helps with menstrual and premenstrual cramps and pain from the common cold or flu
Dosage instructions: Adults and children 12 years and older take two gelcaps every six hours while symptoms last; do not exceed six gelcaps in 24 hours; always follow the label directions for safe use of acetaminophen and dosing guidance
Doctor-recommended brand: Choose Tylenol, the #1 doctor-recommended brand for pain relief and fever reduction based on 2021 IQVIA survey; over-the-counter medication with 500 mg acetaminophen per gelcap that’s gentle on the stomach
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9.5
Superb
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9.5
Superb
Tylenol
Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes for Fast Release, Gentle on Stomach, 500 mg Per Gelcap, 100 Count OTC Medicine
25% Off
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Why we love it
Fast relief from aches.
Gentle on the stomach.
Doctor recommended for pain.
Main Highlights
Fast-acting relief: Tylenol Extra Strength Rapid Release Gels feature 500 mg acetaminophen per gelcap to temporarily relieve minor aches and pains from headache, backache, arthritis, toothache, menstrual cramps, muscle aches, and fever; 100-count
Rapid-release technology: Laser-drilled holes in each gelcap release acetaminophen faster for extra strength pain relief; gelcaps are gentle on the stomach and suitable for adults and children 12 years and older
Multi-symptom support: Use as a fever reducer and to relieve headache, backache, muscle aches, arthritis pain, toothache, and joint discomfort; also helps with menstrual and premenstrual cramps and pain from the common cold or flu
Dosage instructions: Adults and children 12 years and older take two gelcaps every six hours while symptoms last; do not exceed six gelcaps in 24 hours; always follow the label directions for safe use of acetaminophen and dosing guidance
Doctor-recommended brand: Choose Tylenol, the #1 doctor-recommended brand for pain relief and fever reduction based on 2021 IQVIA survey; over-the-counter medication with 500 mg acetaminophen per gelcap that’s gentle on the stomach
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5
Tylenol 8HR Arthritis Pain Relief Caplets, 650 mg Acetaminophen for Minor Arthritis & Joint Pain, Fever Reducer, Extended Release, Gentle on Stomach, 100 ct
Tylenol
Why we love it
Fast-acting pain relief.
Long-lasting effects.
Trusted and doctor recommended.
Main Highlights
Arthritis pain relief: Acetaminophen 650mg extended release formula provides fast-acting, long-lasting relief for minor arthritis and joint pain in hands, wrists, knees, ankles, elbows, and feet; effective for up to 8 hours per dose
Acetaminophen formula: Each caplet contains 650 mg of acetaminophen in an extended-release formula specifically designed for arthritis pain relief; effectively targets joint inflammation and discomfort while also reducing fever when needed
Bi-layer technology: Pain relief pills feature a dual-layer design—first layer releases fast-acting acetaminophen for quick relief, second layer extends pain relief for up to 8 hours; gentle on the stomach for comfort
Safe & trusted: Aspirin-free, OTC pain relief pills are suitable for adults 18+; safe when used as directed and gentle on the stomach
Product details: Each bottle contains 100 extended-release caplets of acetaminophen 650mg; country of origin: USA; pain relief pills are aspirin-free and designed for effective, long-lasting arthritis pain relief
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9.4
Superb
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9.4
Superb
Tylenol
Tylenol 8HR Arthritis Pain Relief Caplets, 650 mg Acetaminophen for Minor Arthritis & Joint Pain, Fever Reducer, Extended Release, Gentle on Stomach, 100 ct
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Show More
Why we love it
Fast-acting pain relief.
Long-lasting effects.
Trusted and doctor recommended.
Main Highlights
Arthritis pain relief: Acetaminophen 650mg extended release formula provides fast-acting, long-lasting relief for minor arthritis and joint pain in hands, wrists, knees, ankles, elbows, and feet; effective for up to 8 hours per dose
Acetaminophen formula: Each caplet contains 650 mg of acetaminophen in an extended-release formula specifically designed for arthritis pain relief; effectively targets joint inflammation and discomfort while also reducing fever when needed
Bi-layer technology: Pain relief pills feature a dual-layer design—first layer releases fast-acting acetaminophen for quick relief, second layer extends pain relief for up to 8 hours; gentle on the stomach for comfort
Safe & trusted: Aspirin-free, OTC pain relief pills are suitable for adults 18+; safe when used as directed and gentle on the stomach
Product details: Each bottle contains 100 extended-release caplets of acetaminophen 650mg; country of origin: USA; pain relief pills are aspirin-free and designed for effective, long-lasting arthritis pain relief
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6
Tylenol Extra Strength Pain Relief Pills, Acetaminophen 500mg Caplets, Pain Reliever and Fever Reducer Medicine for Headache, Backache, Toothache & Minor Arthritis, 100 Count Bottle
Tylenol
9% Off
Why we love it
Fast relief for minor aches.
Reliable fever reducer option.
Doctor recommended for safety.
Main Highlights
Convenient packaging: choose a 100-count bottle or 50 travel pouches of 2 coated caplets for on-the-go pain relief pills; portable design fits purses, backpacks and luggage for quick access whenever and wherever you need relief.
Extra strength relief: each coated caplet contains acetaminophen 500mg to temporarily relieve headache, backache, toothache, minor arthritis pain and muscular aches; take two every 6 hours; do not exceed six caplets in 24 hours.
Pain reliever and fever reducer: acetaminophen temporarily reduces fever and relieves aches due to the common cold, menstrual cramps, muscular soreness and everyday aches, providing broad comfort for adults; always use as directed on the label.
Non-aspirin formula: coated caplets have an excellent safety profile when used as directed; suitable for adults and children 12 years and older for relief of common pains and fever reduction. (225 characters)
Trusted brand: from Tylenol, Extra Strength Caplets deliver reliable, consistent results you can count on for everyday aches and fever when used as directed.
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9.3
Superb
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9.3
Superb
Tylenol
Tylenol Extra Strength Pain Relief Pills, Acetaminophen 500mg Caplets, Pain Reliever and Fever Reducer Medicine for Headache, Backache, Toothache & Minor Arthritis, 100 Count Bottle
9% Off
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Show More
Why we love it
Fast relief for minor aches.
Reliable fever reducer option.
Doctor recommended for safety.
Main Highlights
Convenient packaging: choose a 100-count bottle or 50 travel pouches of 2 coated caplets for on-the-go pain relief pills; portable design fits purses, backpacks and luggage for quick access whenever and wherever you need relief.
Extra strength relief: each coated caplet contains acetaminophen 500mg to temporarily relieve headache, backache, toothache, minor arthritis pain and muscular aches; take two every 6 hours; do not exceed six caplets in 24 hours.
Pain reliever and fever reducer: acetaminophen temporarily reduces fever and relieves aches due to the common cold, menstrual cramps, muscular soreness and everyday aches, providing broad comfort for adults; always use as directed on the label.
Non-aspirin formula: coated caplets have an excellent safety profile when used as directed; suitable for adults and children 12 years and older for relief of common pains and fever reduction. (225 characters)
Trusted brand: from Tylenol, Extra Strength Caplets deliver reliable, consistent results you can count on for everyday aches and fever when used as directed.
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7
Amazon Basic Care Naproxen Sodium Tablets 220 mg, Pain Reliever/Fever Reducer (NSAID), Muscular Aches, Backache, Headache, Toothache, Minor Arthritis Pain Relief & More, 300 Count (Packaging may vary)
Amazon Basic Care
Why we love it
Long-lasting relief for 12 hours.
Effective for various minor pains.
Gluten-free and easy to swallow.
Main Highlights
ACTIVE INGREDIENT: This pain reliever and fever reducer contains naproxen sodium 220 mg, a nonsteroidal anti-inflammatory drug (NSAID); compare to the active ingredient in Aleve Caplets
STRENGTH TO LAST 12 HOURS: Pain reliever and fever reduction for up to 12 hours so you can get through the day
ACHES AND PAINS: Temporarily relieves minor aches and pains due to minor pain of arthritis, muscular aches, backache, menstrual cramps, headache, toothache and the common cold; also temporarily reduces fever
ALL DAY RELIEF: Amazon Basic Care Naproxen Sodium Tablets 220 mg is a pain reliever and fever reducer for adults and children age 12 years and over
CAPSULE-SHAPED TABLETS: This 12 hour pain reliever and fever reducer comes in a capsule-shaped tablet; this product is gluten free
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9.1
Superb
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9.1
Superb
Amazon Basic Care
Amazon Basic Care Naproxen Sodium Tablets 220 mg, Pain Reliever/Fever Reducer (NSAID), Muscular Aches, Backache, Headache, Toothache, Minor Arthritis Pain Relief & More, 300 Count (Packaging may vary)
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Show More
Why we love it
Long-lasting relief for 12 hours.
Effective for various minor pains.
Gluten-free and easy to swallow.
Main Highlights
ACTIVE INGREDIENT: This pain reliever and fever reducer contains naproxen sodium 220 mg, a nonsteroidal anti-inflammatory drug (NSAID); compare to the active ingredient in Aleve Caplets
STRENGTH TO LAST 12 HOURS: Pain reliever and fever reduction for up to 12 hours so you can get through the day
ACHES AND PAINS: Temporarily relieves minor aches and pains due to minor pain of arthritis, muscular aches, backache, menstrual cramps, headache, toothache and the common cold; also temporarily reduces fever
ALL DAY RELIEF: Amazon Basic Care Naproxen Sodium Tablets 220 mg is a pain reliever and fever reducer for adults and children age 12 years and over
CAPSULE-SHAPED TABLETS: This 12 hour pain reliever and fever reducer comes in a capsule-shaped tablet; this product is gluten free
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8
Motrin Dual Action with Tylenol, Ibuprofen & Acetaminophen Fast-Acting Dual Action Pain Reliever for Minor Aches & Pains, Ibuprofen (NSAID) 125 mg & Acetaminophen 250 mg, 120 ct
Motrin
20% Off
Why we love it
Dual action formula effectively relieves pain.
Includes both acetaminophen and ibuprofen.
Targets various types of pain.
Main Highlights
Dual Action Pain Reliever: One 120 count bottle of Motrin Dual Action with Tylenol, dual action ibuprofen (NSAID) and acetaminophen, pain reliever with two medicines for minor aches and pains
Acetaminophen and Ibuprofen: The dual action Motrin with Tylenol pain relief tablets each contain 250 mg acetaminophen plus 125 mg ibuprofen (nonsteroidal anti-inflammatory drug) to temporarily relieve minor aches and pains
Muscle Pain Relief: Use this 2-in-1 pain reliever medicine to temporarily relieve minor aches and pains due to headache, toothache, and muscle aches; Motrin Dual Action with Tylenol works for period cramps pain relief and is an arthritis pain reliever
Pain Relief for Adults: Motrin Dual Action with Tylenol pain relief medicine is intended for adults and children 12 years of age and older with minor aches and pains; take two pain relief tablets every 8 hours while symptoms persist
Contains Acetaminophen: Motrin Dual Action with Tylenol contains acetaminophen; severe liver damage may occur if you take with other drugs containing acetaminophen
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9.0
Superb
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9.0
Superb
Motrin
Motrin Dual Action with Tylenol, Ibuprofen & Acetaminophen Fast-Acting Dual Action Pain Reliever for Minor Aches & Pains, Ibuprofen (NSAID) 125 mg & Acetaminophen 250 mg, 120 ct
20% Off
Check Price
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Why we love it
Dual action formula effectively relieves pain.
Includes both acetaminophen and ibuprofen.
Targets various types of pain.
Main Highlights
Dual Action Pain Reliever: One 120 count bottle of Motrin Dual Action with Tylenol, dual action ibuprofen (NSAID) and acetaminophen, pain reliever with two medicines for minor aches and pains
Acetaminophen and Ibuprofen: The dual action Motrin with Tylenol pain relief tablets each contain 250 mg acetaminophen plus 125 mg ibuprofen (nonsteroidal anti-inflammatory drug) to temporarily relieve minor aches and pains
Muscle Pain Relief: Use this 2-in-1 pain reliever medicine to temporarily relieve minor aches and pains due to headache, toothache, and muscle aches; Motrin Dual Action with Tylenol works for period cramps pain relief and is an arthritis pain reliever
Pain Relief for Adults: Motrin Dual Action with Tylenol pain relief medicine is intended for adults and children 12 years of age and older with minor aches and pains; take two pain relief tablets every 8 hours while symptoms persist
Contains Acetaminophen: Motrin Dual Action with Tylenol contains acetaminophen; severe liver damage may occur if you take with other drugs containing acetaminophen
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9
A+Health Dual Action Acetaminophen 250 mg and Ibuprofen (NSAID) 125mg Pain Reliever Caplets, 216 Count
A+Health
Why we love it
Effective dual-action formulation.
Long-lasting pain relief support.
Convenient and easy to use.
Main Highlights
ACTIVE INGREDIENTS: A+ Health Dual Action Pain Reliever tablets contain 250 mg of Acetaminophen and 125 mg of Ibuprofen. Compare to the active ingredients in the National Brand.
UP TO 8 HOURS OF PAIN RELIEF: Provides temporary pain relief due to headache, backache, muscular aches, toothache, menstrual cramps and minor pain of arthritis.
DUAL ACTION PAIN RELIEVER: Contains 2 medicines for pain fighting relief: Acetaminophen 250 mg and Ibuprofen 125 mg in one caplet.
DIRECTIONS: Adults and children 12 years and over: take 2 caplets every 8 hours while symptoms persist. Do not take more than 6 caplets in 24 hours, unless directed by a doctor. Children under 12 years: Ask a doctor. Please see packaging for full Drug Fact information.
DON’T LET PAIN GET IN YOUR WAY: You can find relief with A+ Health Dual Action Pain Reliever. Each bottle contains 216 capsule-shaped tablets.
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9.0
Superb
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9.0
Superb
A+Health
A+Health Dual Action Acetaminophen 250 mg and Ibuprofen (NSAID) 125mg Pain Reliever Caplets, 216 Count
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Why we love it
Effective dual-action formulation.
Long-lasting pain relief support.
Convenient and easy to use.
Main Highlights
ACTIVE INGREDIENTS: A+ Health Dual Action Pain Reliever tablets contain 250 mg of Acetaminophen and 125 mg of Ibuprofen. Compare to the active ingredients in the National Brand.
UP TO 8 HOURS OF PAIN RELIEF: Provides temporary pain relief due to headache, backache, muscular aches, toothache, menstrual cramps and minor pain of arthritis.
DUAL ACTION PAIN RELIEVER: Contains 2 medicines for pain fighting relief: Acetaminophen 250 mg and Ibuprofen 125 mg in one caplet.
DIRECTIONS: Adults and children 12 years and over: take 2 caplets every 8 hours while symptoms persist. Do not take more than 6 caplets in 24 hours, unless directed by a doctor. Children under 12 years: Ask a doctor. Please see packaging for full Drug Fact information.
DON’T LET PAIN GET IN YOUR WAY: You can find relief with A+ Health Dual Action Pain Reliever. Each bottle contains 216 capsule-shaped tablets.
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10
A+Health Ibuprofen 200 Mg Softgels, Pain Reliever/Fever Reducer (NSAID), 300 Count
A+Health
Why we love it
Effective pain relief solution.
Convenient liquid-filled softgels.
Great value for everyday use.
Main Highlights
ACTIVE INGREDIENT IBUPROFEN 200MG: Contains active ingredient Ibuprofen 200mg (nonsteroidal anti-inflammatory drug)—compare to the active ingredient in Advil Liquid-Gels
TEMPORARY PAIN RELIEF: Temporarily reduces fever and relieves minor aches and pains due to headache, toothache, backache, menstrual cramps, the common cold, muscular aches, and minor pain of arthritis
SOFTGELS: Each bottle contains 300 softgels, which are liquid-filled capsules
GREAT VALUE: Provides temporary relief from most common aches and pains at a great value
DON'T LET PAIN GET IN YOUR WAY: Whether you have minor arthritis pain or other aches or pains, you can find relief with A+ Health Ibuprofen 200mg Softgels
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8.8
Excellent
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8.8
Excellent
A+Health
A+Health Ibuprofen 200 Mg Softgels, Pain Reliever/Fever Reducer (NSAID), 300 Count
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Show More
Why we love it
Effective pain relief solution.
Convenient liquid-filled softgels.
Great value for everyday use.
Main Highlights
ACTIVE INGREDIENT IBUPROFEN 200MG: Contains active ingredient Ibuprofen 200mg (nonsteroidal anti-inflammatory drug)—compare to the active ingredient in Advil Liquid-Gels
TEMPORARY PAIN RELIEF: Temporarily reduces fever and relieves minor aches and pains due to headache, toothache, backache, menstrual cramps, the common cold, muscular aches, and minor pain of arthritis
SOFTGELS: Each bottle contains 300 softgels, which are liquid-filled capsules
GREAT VALUE: Provides temporary relief from most common aches and pains at a great value
DON'T LET PAIN GET IN YOUR WAY: Whether you have minor arthritis pain or other aches or pains, you can find relief with A+ Health Ibuprofen 200mg Softgels
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