10 Best Non Aspirin of 2025

Last updated on 09/30/2025

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Nuvicare Tension Headache Relief Pills with 500mg Acetaminophen and 65mg Caffeine - Non Aspirin Pain Reliever Aid - Compare to Active Ingredient in Aspirin Free Excedrin Tension Headache (100 Caplets)

Nuvicare Tension Headache Relief Pills with 500mg Acetaminophen and 65mg Caffeine - Non Aspirin Pain Reliever Aid - Compare to Active Ingredient in Aspirin Free Excedrin Tension Headache (100 Caplets)

NUVICARE

23% OffFree Shipping

Why we love it

Targeted relief from tension headaches.
Aspirin-free for sensitive individuals.
Fast-acting and effective solution.

Main Highlights

TARGETED RELIEF FOR TENSION HEADACHES - Don’t let the pressure and tightness in your head hold you back. With a combination of 500mg of acetaminophen and 65mg of caffeine, these tension headache pills work effectively to ease tension and give you the relief you need to power through.
COMPARE TO ACTIVE INGREDIENT IN EXCEDRIN - Our OTC tension headache medicine provides the same trusted active ingredients as major brands without the higher price tag. Formulated to target headaches fast with the same amount of acetaminophen (500 mg) and caffeine (65 mg).
ASPIRIN-FREE HEAD CARE FORMULA - No need to worry about aspirin if it’s not right for you. Our aspirin-free formula delivers powerful head tension relief from tension headaches, helping you manage pain and pressure symptoms without any unnecessary ingredients.
FAST & EFFECTIVE RELIEF - Tension headaches can be incredibly disruptive to your day, making it hard to focus and get anything done. Which is why you need relief quickly. With our powerful dual action of acetaminophen and caffeine, Nuvicare works fast against pain to get you back on track.
QUALITY YOU CAN TRUST - Nuvicare Tension Headache relief caplets are produced in a GMP facility that meets stringent quality and safety standards. Count on Nuvicare for trusted, effective OTC solutions at generic value, providing the quality you deserve for your health needs.

9.7

Exceptional

Targeted relief from tension headaches.
Aspirin-free for sensitive individuals.
Fast-acting and effective solution.

Main Highlights

TARGETED RELIEF FOR TENSION HEADACHES - Don’t let the pressure and tightness in your head hold you back. With a combination of 500mg of acetaminophen and 65mg of caffeine, these tension headache pills work effectively to ease tension and give you the relief you need to power through.
COMPARE TO ACTIVE INGREDIENT IN EXCEDRIN - Our OTC tension headache medicine provides the same trusted active ingredients as major brands without the higher price tag. Formulated to target headaches fast with the same amount of acetaminophen (500 mg) and caffeine (65 mg).
ASPIRIN-FREE HEAD CARE FORMULA - No need to worry about aspirin if it’s not right for you. Our aspirin-free formula delivers powerful head tension relief from tension headaches, helping you manage pain and pressure symptoms without any unnecessary ingredients.
FAST & EFFECTIVE RELIEF - Tension headaches can be incredibly disruptive to your day, making it hard to focus and get anything done. Which is why you need relief quickly. With our powerful dual action of acetaminophen and caffeine, Nuvicare works fast against pain to get you back on track.
QUALITY YOU CAN TRUST - Nuvicare Tension Headache relief caplets are produced in a GMP facility that meets stringent quality and safety standards. Count on Nuvicare for trusted, effective OTC solutions at generic value, providing the quality you deserve for your health needs.

Value for Money

Aleve Pain Reliever & Fever Reducer Naproxen Sodium Caplets, Body and Arthritis Pain Reliever, Medicine for Adults and Children Ages 12 and Up, 60 Individual Pouches

Aleve Pain Reliever & Fever Reducer Naproxen Sodium Caplets, Body and Arthritis Pain Reliever, Medicine for Adults and Children Ages 12 and Up, 60 Individual Pouches

Aleve

Free Shipping

Why we love it

Convenient for on-the-go relief.
Long-lasting pain management solution.
Effective for various pain types.

Main Highlights

On the Go: Take the power of Aleve with you, anywhere you go
Up to 12-Hours of Uninterrupted Pain Relief: Aleve Pain Reliever & Fever Reducer Gelcaps provide long-lasting pain relief of muscle pain, arthritis & joint pain, backache, toothache, menstrual cramps, and headache
Fever Reducer: Temporarily reduces fever for adults and children aged 12 and up
Targeted Pain Relief: Relieves minor pain from arthritis, muscular aches, backache, headache, and the common cold
Effective Pain Reliever: In a study, proven as effective and longer lasting than a common Rx pain reliever. Ask a doctor if Aleve is right for you

Aleve Pain Reliever & Fever Reducer Naproxen Sodium Caplets, Body and Arthritis Pain Reliever, Medicine for Adults and Children Ages 12 and Up, 60 Individual Pouches

Free Shipping

Why we love it

Convenient for on-the-go relief.
Long-lasting pain management solution.
Effective for various pain types.

Main Highlights

On the Go: Take the power of Aleve with you, anywhere you go
Up to 12-Hours of Uninterrupted Pain Relief: Aleve Pain Reliever & Fever Reducer Gelcaps provide long-lasting pain relief of muscle pain, arthritis & joint pain, backache, toothache, menstrual cramps, and headache
Fever Reducer: Temporarily reduces fever for adults and children aged 12 and up
Targeted Pain Relief: Relieves minor pain from arthritis, muscular aches, backache, headache, and the common cold
Effective Pain Reliever: In a study, proven as effective and longer lasting than a common Rx pain reliever. Ask a doctor if Aleve is right for you

Medique @ Home 70433 Extra Strength APAP Tablets, Non-Aspirin, 50 Packets (2 Tablets per Packet) Total-100 Count

Medique @ Home 70433 Extra Strength APAP Tablets, Non-Aspirin, 50 Packets (2 Tablets per Packet) Total-100 Count

Medique

Free Shipping

Why we love it

Trusted brand for home care.
Effective pain relief solution.
User-friendly and easy to swallow.

Main Highlights

Medique @ Home the brands that work now work at home
Each tablet contains Acetaminophen 500mg
Easy to swallow film coated tablets
Compare active ingredient to Extra Strength Tylenol

Medique @ Home 70433 Extra Strength APAP Tablets, Non-Aspirin, 50 Packets (2 Tablets per Packet) Total-100 Count

Free Shipping

Why we love it

Trusted brand for home care.
Effective pain relief solution.
User-friendly and easy to swallow.

Main Highlights

Medique @ Home the brands that work now work at home
Each tablet contains Acetaminophen 500mg
Easy to swallow film coated tablets
Compare active ingredient to Extra Strength Tylenol

HealthA2Z® Pain Relief Extended Release | Acetaminophen 650mg | 250 Caplets | 8 Hours | Arthiritis Pain | Pain Reliever - Fever Reducer | Contains no Aspirin (250 Count)

HealthA2Z

Free Shipping

Why we love it

Effective Pain Management Solution.
Long-Lasting Relief with Convenience.
Ideal for Arthritis Discomfort.

Main Highlights

Pain Reliever
Fever Reducer
Arthiritis Pain Relief
8 Hours, Extended Release Caplets

Effective Pain Management Solution.
Long-Lasting Relief with Convenience.
Ideal for Arthritis Discomfort.

Main Highlights

Pain Reliever
Fever Reducer
Arthiritis Pain Relief
8 Hours, Extended Release Caplets

First Aid Only SC Refill Extra Strength Non-Aspirin, 10x2/box

First Aid Only

Free Shipping

Why we love it

Efficient supply organization guaranteed.
Safe and sterile packaging ensured.
Perfect for on-the-go relief.

Main Highlights

SmartCompliance Refill: Keeps first aid supplies organized and stocked efficiently.
Extra Strength Formula: Provides temporary relief for headaches, muscle aches, arthritis, toothaches, and menstrual cramps.
Tamper-Evident Packaging: Ensures safety and sterility of each dose.
Convenient & Portable: Includes 10 packets, each containing 2 tablets for easy storage and use.
Ideal for First Aid Kits: Compatible with various First Aid Only SmartCompliance cabinets.

First Aid Only SC Refill Extra Strength Non-Aspirin, 10x2/box

Free Shipping

Why we love it

Efficient supply organization guaranteed.
Safe and sterile packaging ensured.
Perfect for on-the-go relief.

Main Highlights

SmartCompliance Refill: Keeps first aid supplies organized and stocked efficiently.
Extra Strength Formula: Provides temporary relief for headaches, muscle aches, arthritis, toothaches, and menstrual cramps.
Tamper-Evident Packaging: Ensures safety and sterility of each dose.
Convenient & Portable: Includes 10 packets, each containing 2 tablets for easy storage and use.
Ideal for First Aid Kits: Compatible with various First Aid Only SmartCompliance cabinets.

HealthA2Z® Extra Strength Pain Relief | Acetaminophen 500mg | Contains No Aspirin | Fever Reducer | Pain Reliever (500 Count (Pack of 1))

HealthA2Z® Extra Strength Pain Relief | Acetaminophen 500mg | Contains No Aspirin | Fever Reducer | Pain Reliever (500 Count (Pack of 1))

HealthA2Z® Extra Strength Pain Relief | Acetaminophen 500mg | Contains No Aspirin | Fever Reducer | Pain Reliever (500 Count (Pack of 1))

Free Shipping

GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count

GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count

GoodSense

Free Shipping

Why we love it

Effective pain relief solution.
Trusted active ingredient formula.
Fast-acting for various pains.

Main Highlights

ACTIVE INGREDIENT: GoodSense Extra Strength Pain Relief's active ingredient is Acetaminophen, 500 mg, which compares to the active ingredient of Extra Strength Tylenol Caplets
GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, temporarily relieves minor aches and pains due to: the common cold, headache, backache, minor pain of arthritis, toothache, muscular aches, and premenstrual and menstrual cramps. It also temporarily reduces fever
USE: Acetaminophen may be used as a pain reliever and fever reducer for adults and children 12 years and over
PAIN: Pain may begin with an injury or illness, but could also originate with anything from a bad mattress to arthritis
ACUTE PAIN: Acute pain acts as an alarm such as with a bee sting or stubbing your toe and can last for a few moments or for longer

GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count

Free Shipping

Why we love it

Effective pain relief solution.
Trusted active ingredient formula.
Fast-acting for various pains.

Main Highlights

ACTIVE INGREDIENT: GoodSense Extra Strength Pain Relief's active ingredient is Acetaminophen, 500 mg, which compares to the active ingredient of Extra Strength Tylenol Caplets
GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, temporarily relieves minor aches and pains due to: the common cold, headache, backache, minor pain of arthritis, toothache, muscular aches, and premenstrual and menstrual cramps. It also temporarily reduces fever
USE: Acetaminophen may be used as a pain reliever and fever reducer for adults and children 12 years and over
PAIN: Pain may begin with an injury or illness, but could also originate with anything from a bad mattress to arthritis
ACUTE PAIN: Acute pain acts as an alarm such as with a bee sting or stubbing your toe and can last for a few moments or for longer

Excedrin Tension Headache Relief Caplets, Acetaminophen 500mg, Caffeine 65mg, Pain Reliever, Aspirin-Free, 100 Count

Excedrin Tension Headache Relief Caplets, Acetaminophen 500mg, Caffeine 65mg, Pain Reliever, Aspirin-Free, 100 Count

Excedrin

23% OffFree Shipping

Why we love it

Aspirin-free formula offers comfort.
Fast relief from tension headaches.
Convenient caplet form for ease.

Main Highlights

One bottle of 100 caplets of Excedrin Tension Headache Relief Caplets Without Aspirin for Head, Neck and Shoulder Pain Relief
Aspirin-free tension headache pain medicine that quickly relieves headaches and pain caused by tension and stress
Delivers muscle ache, shoulder and neck pain relief
Combines acetaminophen with caffeine to temporarily relieve pain caused by headaches and muscle aches
Contains a trusted formula that combines a pain reliever and an amplifier
Effectively relieves tension-type headaches in convenient caplet form
HSA and FSA eligible product

Excedrin Tension Headache Relief Caplets, Acetaminophen 500mg, Caffeine 65mg, Pain Reliever, Aspirin-Free, 100 Count

23% OffFree Shipping

Why we love it

Aspirin-free formula offers comfort.
Fast relief from tension headaches.
Convenient caplet form for ease.

Main Highlights

One bottle of 100 caplets of Excedrin Tension Headache Relief Caplets Without Aspirin for Head, Neck and Shoulder Pain Relief
Aspirin-free tension headache pain medicine that quickly relieves headaches and pain caused by tension and stress
Delivers muscle ache, shoulder and neck pain relief
Combines acetaminophen with caffeine to temporarily relieve pain caused by headaches and muscle aches
Contains a trusted formula that combines a pain reliever and an amplifier
Effectively relieves tension-type headaches in convenient caplet form
HSA and FSA eligible product

Globe Aspirin Tablets, 325 mg - 100 Count, Single Use Packets, NSAID Pain Relief, Pain Reliever & Fever Reducer, Arthritis Pain Relief, Headache Relief, Migraine Medicine Aspirin Pain Reliever.

Globe Aspirin Tablets, 325 mg - 100 Count, Single Use Packets, NSAID Pain Relief, Pain Reliever & Fever Reducer, Arthritis Pain Relief, Headache Relief, Migraine Medicine Aspirin Pain Reliever.

Globe

Free Shipping

Why we love it

Regular strength for daily relief.
Pure uncoated for fast absorption.
Convenient packets for on-the-go.

Main Highlights

* REGULAR STRENGTH 325mg ASPIRIN [NSAID]: Globe Aspirin offers 325mg of pure aspirin per tablet which is the optimal amount for everyday aches and pains. Just the recommended, regular-strength dose any adult or teenager can fully benefit from. NSAID - nonsteroidal anti-inflammatory drug. Compare to the active ingredient of Bayer Aspirin.
* PURE, UNCOATED ASPIRIN FOR FASTER ABSORPTION: Completely free of synthetic coating, flavorings, dyes or other fillers. Globes uncoated aspirin tablets make a safe choice for anyone, especially those who prefer a purer painkiller. Plus, non-coated aspirin is faster and easier to be absorbed than the coated ones for that immediate pain relief you are looking for
EASY TO TAKE WITH YOU: Keep Globe Aspirin 325mg Packets in your medicine closet, first aid kit, car, camping bag, purse, kitchen drawer, kid's backpack, and even your travel carryon luggage. The convenience of these packets allows you to take them anywhere.
PAIN RELIEF: Use Aspirin to temporarily relieve minor aches and pains due to headache, muscular aches, arthritis, toothache, backache, the common cold and menstrual cramps.
QUALITY: Manufactured in accordance with the highest pharmaceutical manufacturing processes and contains a NDC for 100% confidence. Made in the USA. Trifecta Pharmaceuticals USA is a family business based in sunny Fort Lauderdale, Florida USA.

Globe Aspirin Tablets, 325 mg - 100 Count, Single Use Packets, NSAID Pain Relief, Pain Reliever & Fever Reducer, Arthritis Pain Relief, Headache Relief, Migraine Medicine Aspirin Pain Reliever.

Free Shipping

Why we love it

Regular strength for daily relief.
Pure uncoated for fast absorption.
Convenient packets for on-the-go.

Main Highlights

* REGULAR STRENGTH 325mg ASPIRIN [NSAID]: Globe Aspirin offers 325mg of pure aspirin per tablet which is the optimal amount for everyday aches and pains. Just the recommended, regular-strength dose any adult or teenager can fully benefit from. NSAID - nonsteroidal anti-inflammatory drug. Compare to the active ingredient of Bayer Aspirin.
* PURE, UNCOATED ASPIRIN FOR FASTER ABSORPTION: Completely free of synthetic coating, flavorings, dyes or other fillers. Globes uncoated aspirin tablets make a safe choice for anyone, especially those who prefer a purer painkiller. Plus, non-coated aspirin is faster and easier to be absorbed than the coated ones for that immediate pain relief you are looking for
EASY TO TAKE WITH YOU: Keep Globe Aspirin 325mg Packets in your medicine closet, first aid kit, car, camping bag, purse, kitchen drawer, kid's backpack, and even your travel carryon luggage. The convenience of these packets allows you to take them anywhere.
PAIN RELIEF: Use Aspirin to temporarily relieve minor aches and pains due to headache, muscular aches, arthritis, toothache, backache, the common cold and menstrual cramps.
QUALITY: Manufactured in accordance with the highest pharmaceutical manufacturing processes and contains a NDC for 100% confidence. Made in the USA. Trifecta Pharmaceuticals USA is a family business based in sunny Fort Lauderdale, Florida USA.

TIME-CAP LABS, INC. Timely Ibuprofen 200mg 500 Tablets - (NSAID) Pain Relief Pills for Headache, Menstrual Pain, Tooth Aches, Muscle Pain, Arthritis Pain, Body Aches

TIME-CAP LABS, INC. Timely Ibuprofen 200mg 500 Tablets - (NSAID) Pain Relief Pills for Headache, Menstrual Pain, Tooth Aches, Muscle Pain, Arthritis Pain, Body Aches

TIME-CAP LABS, INC.

Free Shipping

Why we love it

Effective relief for all ages.
Cost-effective without sacrificing quality.
Smooth and easy to swallow.

Main Highlights

Pain Relief You Can Count On ... Don't let nagging aches hold you back. With a full-strength serving of ibuprofen 200mg, our pain relief pills help you stand up to headaches, toothaches, minor pain of arthritis, backaches, and offer menstrual cramps relief.
Show That Fever Who's Boss ... Ibuprofen does more than just keep aches in check, it's also an effective fever reducer for adults and children 12 years and over. When that flu reaches a crescendo and your forehead feels like a furnace, these ibuprofen tablets just might help.
Impressive Results at a Fraction of the Cost ... Don't fall into the branding trap. Our headache relief pills have National Brand Equivalency. This means you get the same quality as products that are 2X as expensive. Be savvy. Shop smart. Save big.
Smooth Ingestion... Our Ibuprofen 200mg tablets, with their exceptionally smooth and sleek coating, transform the act of swallowing into a breeze.
Effective Pain Relief for the Family … One of our core missions is to bring affordable and quality-tested pain relief for your family. With 500 tablets on each bottle, you’ll have enough pain relief for months to come.

TIME-CAP LABS, INC. Timely Ibuprofen 200mg 500 Tablets - (NSAID) Pain Relief Pills for Headache, Menstrual Pain, Tooth Aches, Muscle Pain, Arthritis Pain, Body Aches

Free Shipping

Why we love it

Effective relief for all ages.
Cost-effective without sacrificing quality.
Smooth and easy to swallow.

Main Highlights

Pain Relief You Can Count On ... Don't let nagging aches hold you back. With a full-strength serving of ibuprofen 200mg, our pain relief pills help you stand up to headaches, toothaches, minor pain of arthritis, backaches, and offer menstrual cramps relief.
Show That Fever Who's Boss ... Ibuprofen does more than just keep aches in check, it's also an effective fever reducer for adults and children 12 years and over. When that flu reaches a crescendo and your forehead feels like a furnace, these ibuprofen tablets just might help.
Impressive Results at a Fraction of the Cost ... Don't fall into the branding trap. Our headache relief pills have National Brand Equivalency. This means you get the same quality as products that are 2X as expensive. Be savvy. Shop smart. Save big.
Smooth Ingestion... Our Ibuprofen 200mg tablets, with their exceptionally smooth and sleek coating, transform the act of swallowing into a breeze.
Effective Pain Relief for the Family … One of our core missions is to bring affordable and quality-tested pain relief for your family. With 500 tablets on each bottle, you’ll have enough pain relief for months to come.