10 Best Non Aspirin of 2026

Last updated on 02/03/2026

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Nuvicare Tension Headache Relief Pills with 500mg Acetaminophen and 65mg Caffeine - Non Aspirin Pain Reliever Aid - Compare to Active Ingredient in Aspirin Free Excedrin Tension Headache (100 Caplets)

Nuvicare Tension Headache Relief Pills with 500mg Acetaminophen and 65mg Caffeine - Non Aspirin Pain Reliever Aid - Compare to Active Ingredient in Aspirin Free Excedrin Tension Headache (100 Caplets)

NUVICARE

46% Off

Why we love it

Targeted relief from tension headaches.
Aspirin-free for sensitive individuals.
Fast-acting and effective solution.

Main Highlights

TARGETED RELIEF FOR TENSION HEADACHES - Don’t let the pressure and tightness in your head hold you back. With a combination of 500mg of acetaminophen and 65mg of caffeine, these tension headache pills work effectively to ease tension and give you the relief you need to power through.
COMPARE TO ACTIVE INGREDIENT IN EXCEDRIN - Our OTC tension headache medicine provides the same trusted active ingredients as major brands without the higher price tag. Formulated to target headaches fast with the same amount of acetaminophen (500 mg) and caffeine (65 mg).
ASPIRIN-FREE HEAD CARE FORMULA - No need to worry about aspirin if it’s not right for you. Our aspirin-free formula delivers powerful head tension relief from tension headaches, helping you manage pain and pressure symptoms without any unnecessary ingredients.
FAST & EFFECTIVE RELIEF - Tension headaches can be incredibly disruptive to your day, making it hard to focus and get anything done. Which is why you need relief quickly. With our powerful dual action of acetaminophen and caffeine, Nuvicare works fast against pain to get you back on track.
QUALITY YOU CAN TRUST - Nuvicare Tension Headache relief caplets are produced in a GMP facility that meets stringent quality and safety standards. Count on Nuvicare for trusted, effective OTC solutions at generic value, providing the quality you deserve for your health needs.

9.7

Exceptional

9.7

Exceptional

NUVICARE

Nuvicare Tension Headache Relief Pills with 500mg Acetaminophen and 65mg Caffeine - Non Aspirin Pain Reliever Aid - Compare to Active Ingredient in Aspirin Free Excedrin Tension Headache (100 Caplets)

46% Off

Why we love it

Targeted relief from tension headaches.
Aspirin-free for sensitive individuals.
Fast-acting and effective solution.

Main Highlights

TARGETED RELIEF FOR TENSION HEADACHES - Don’t let the pressure and tightness in your head hold you back. With a combination of 500mg of acetaminophen and 65mg of caffeine, these tension headache pills work effectively to ease tension and give you the relief you need to power through.
COMPARE TO ACTIVE INGREDIENT IN EXCEDRIN - Our OTC tension headache medicine provides the same trusted active ingredients as major brands without the higher price tag. Formulated to target headaches fast with the same amount of acetaminophen (500 mg) and caffeine (65 mg).
ASPIRIN-FREE HEAD CARE FORMULA - No need to worry about aspirin if it’s not right for you. Our aspirin-free formula delivers powerful head tension relief from tension headaches, helping you manage pain and pressure symptoms without any unnecessary ingredients.
FAST & EFFECTIVE RELIEF - Tension headaches can be incredibly disruptive to your day, making it hard to focus and get anything done. Which is why you need relief quickly. With our powerful dual action of acetaminophen and caffeine, Nuvicare works fast against pain to get you back on track.
QUALITY YOU CAN TRUST - Nuvicare Tension Headache relief caplets are produced in a GMP facility that meets stringent quality and safety standards. Count on Nuvicare for trusted, effective OTC solutions at generic value, providing the quality you deserve for your health needs.

Value for Money

GeriCare Aspirin Tablets 325mg - Pain Reliever and Fever Reducer Uncoated Aspirins for Adults & Kids 12+ (NSAID) Great for Headache, Toothache, Arthritis, Menstrual & Muscle Pain (Bottle of 1,000)

GeriCare Aspirin Tablets 325mg - Pain Reliever and Fever Reducer Uncoated Aspirins for Adults & Kids 12+ (NSAID) Great for Headache, Toothache, Arthritis, Menstrual & Muscle Pain (Bottle of 1,000)

GeriCare

6% Off

Why we love it

Effective pain relief solution.
No synthetic coatings or fillers.
Large supply for the family.

Main Highlights

REGULAR STRENGTH 325mg ASPIRIN [NSAID]: The GeriCare Aspirins offer 325mg of pure aspirin per tablet which is the optimal amount for everyday aches and pains. Just the recommended, regular-strength dose any adult or teenager can fully benefit from. [NSAID - nonsteroidal anti-inflammatory drug. Compare to the active ingredient of Bayer Aspirin.]
PURE, UNCOATED ASPIRINS FOR FASTER ABSORPTION: Completely free of synthetic coating, flavorings, dyes or other fillers [we just use corn starch as a binder], our uncoated aspirin tablets make a safe choice for anyone, especially those who prefer a purer painkiller. Plus, non-coated aspirins are faster and easier absorbed than the coated ones for that immediate pain relief you long for.
EXTREMELY VERSATILE & EFFECTIVE FOR FEVER, PAINS & ACHES: Our aspirins for adults and kids aged 12+, work wonders on reducing fever and fighting the symptoms of common cold. They also offer temporary relief from headache, toothache, muscle pain, arthritis and period cramps while they can also provide great anti-inflammatory care for an array of conditions.
1,000 ASPIRIN TABLETS PER BOTTLE TO LAST A LONG, LONG TIME: With no less than 1,000 tablets per bottle, you may rest assured that you will not run out of aspirin pills anytime soon. Ideal for the whole family to use. DOSE: Take 1-2 tablets every 4 hours while symptoms last. Do not take more than 12 tablets in 24 hours, unless directed by a doctor.
WITH GERICARE’S SEAL OF EXCELLENCE: With 30 years of experience in creating the highest quality supplements and medical supplies that can make a true difference in your life, you have every good reason to trust GeriCare for your wellbeing. Our expert team of health professionals is always at your disposal for any questions you may have!

GeriCare Aspirin Tablets 325mg - Pain Reliever and Fever Reducer Uncoated Aspirins for Adults & Kids 12+ (NSAID) Great for Headache, Toothache, Arthritis, Menstrual & Muscle Pain (Bottle of 1,000)

6% Off

Why we love it

Effective pain relief solution.
No synthetic coatings or fillers.
Large supply for the family.

Main Highlights

REGULAR STRENGTH 325mg ASPIRIN [NSAID]: The GeriCare Aspirins offer 325mg of pure aspirin per tablet which is the optimal amount for everyday aches and pains. Just the recommended, regular-strength dose any adult or teenager can fully benefit from. [NSAID - nonsteroidal anti-inflammatory drug. Compare to the active ingredient of Bayer Aspirin.]
PURE, UNCOATED ASPIRINS FOR FASTER ABSORPTION: Completely free of synthetic coating, flavorings, dyes or other fillers [we just use corn starch as a binder], our uncoated aspirin tablets make a safe choice for anyone, especially those who prefer a purer painkiller. Plus, non-coated aspirins are faster and easier absorbed than the coated ones for that immediate pain relief you long for.
EXTREMELY VERSATILE & EFFECTIVE FOR FEVER, PAINS & ACHES: Our aspirins for adults and kids aged 12+, work wonders on reducing fever and fighting the symptoms of common cold. They also offer temporary relief from headache, toothache, muscle pain, arthritis and period cramps while they can also provide great anti-inflammatory care for an array of conditions.
1,000 ASPIRIN TABLETS PER BOTTLE TO LAST A LONG, LONG TIME: With no less than 1,000 tablets per bottle, you may rest assured that you will not run out of aspirin pills anytime soon. Ideal for the whole family to use. DOSE: Take 1-2 tablets every 4 hours while symptoms last. Do not take more than 12 tablets in 24 hours, unless directed by a doctor.
WITH GERICARE’S SEAL OF EXCELLENCE: With 30 years of experience in creating the highest quality supplements and medical supplies that can make a true difference in your life, you have every good reason to trust GeriCare for your wellbeing. Our expert team of health professionals is always at your disposal for any questions you may have!

Excedrin Tension Headache Relief Caplets, Acetaminophen 500mg, Caffeine 65mg, Pain Reliever, Aspirin-Free, 100 Count

Excedrin Tension Headache Relief Caplets, Acetaminophen 500mg, Caffeine 65mg, Pain Reliever, Aspirin-Free, 100 Count

Excedrin

19% Off

Why we love it

Aspirin-free formula offers comfort.
Fast relief from tension headaches.
Convenient caplet form for ease.

Main Highlights

One bottle of 100 caplets of Excedrin Tension Headache Relief Caplets Without Aspirin for Head, Neck and Shoulder Pain Relief
Aspirin-free tension headache pain medicine that quickly relieves headaches and pain caused by tension and stress
Delivers muscle ache, shoulder and neck pain relief
Combines acetaminophen with caffeine to temporarily relieve pain caused by headaches and muscle aches
Contains a trusted formula that combines a pain reliever and an amplifier
Effectively relieves tension-type headaches in convenient caplet form
HSA and FSA eligible product

Excedrin Tension Headache Relief Caplets, Acetaminophen 500mg, Caffeine 65mg, Pain Reliever, Aspirin-Free, 100 Count

19% Off

Why we love it

Aspirin-free formula offers comfort.
Fast relief from tension headaches.
Convenient caplet form for ease.

Main Highlights

One bottle of 100 caplets of Excedrin Tension Headache Relief Caplets Without Aspirin for Head, Neck and Shoulder Pain Relief
Aspirin-free tension headache pain medicine that quickly relieves headaches and pain caused by tension and stress
Delivers muscle ache, shoulder and neck pain relief
Combines acetaminophen with caffeine to temporarily relieve pain caused by headaches and muscle aches
Contains a trusted formula that combines a pain reliever and an amplifier
Effectively relieves tension-type headaches in convenient caplet form
HSA and FSA eligible product

St. Joseph Aspirin Pain Reliever (NSAID) 81mg, Enteric Safety Coated, Adult Low Dose Aspirin, 365 ct (1 Year Supply, Packaging May Vary)

St. Joseph Aspirin Pain Reliever (NSAID) 81mg, Enteric Safety Coated, Adult Low Dose Aspirin, 365 ct (1 Year Supply, Packaging May Vary)

St. Joseph

14% Off

Why we love it

Gentle on the stomach lining.
Doctor-recommended heart health support.
Trusted family remedy for generations.

Main Highlights

Easy-to-Swallow Enteric Coated Low Dose Aspirin: Safety coated micro tablets delay aspirin release so that the tablet can pass through the stomach before dissolving to help reduce the potentially irritating effects of aspirin on the stomach lining
Low Dose Aspirin Regimen: Recommended by doctors and leading health organizations to help some individuals prevent a recurring heart attack or ischemic stroke.
Consult Your Doctor: Aspirin therapy is not right for everyone, so always talk to your doctor before starting or changing any aspirin regimen.
Pain Relief: For the temporary relief of minor aches and pains.
Put a Little Love in Your Heart: You put your heart into everything you love. For generations, St. Joseph Low Dose Aspirin has been a staple of households as America’s first and most trusted low dose aspirin for families.

St. Joseph Aspirin Pain Reliever (NSAID) 81mg, Enteric Safety Coated, Adult Low Dose Aspirin, 365 ct (1 Year Supply, Packaging May Vary)

14% Off

Why we love it

Gentle on the stomach lining.
Doctor-recommended heart health support.
Trusted family remedy for generations.

Main Highlights

Easy-to-Swallow Enteric Coated Low Dose Aspirin: Safety coated micro tablets delay aspirin release so that the tablet can pass through the stomach before dissolving to help reduce the potentially irritating effects of aspirin on the stomach lining
Low Dose Aspirin Regimen: Recommended by doctors and leading health organizations to help some individuals prevent a recurring heart attack or ischemic stroke.
Consult Your Doctor: Aspirin therapy is not right for everyone, so always talk to your doctor before starting or changing any aspirin regimen.
Pain Relief: For the temporary relief of minor aches and pains.
Put a Little Love in Your Heart: You put your heart into everything you love. For generations, St. Joseph Low Dose Aspirin has been a staple of households as America’s first and most trusted low dose aspirin for families.

HealthA2Z® Pain Relief Extended Release | Acetaminophen 650mg | 8 Hours | Arthiritis Pain | Pain Reliever - Fever Reducer | Contains no Aspirin | (250 Caplets)

HealthA2Z® Pain Relief Extended Release | Acetaminophen 650mg | 8 Hours | Arthiritis Pain | Pain Reliever - Fever Reducer | Contains no Aspirin | (250 Caplets)

HealthA2Z

Why we love it

Effective Pain Management Solution.
Long-Lasting Relief with Convenience.
Ideal for Arthritis Discomfort.

Main Highlights

Long-Lasting Pain Relief: Formulated with Acetaminophen 650mg to provide up to 8 hours of relief from minor aches and pains.
Targets Multiple Discomforts: Helps temporarily relieve pain associated with arthritis, backache, headache, muscular aches, toothache, and minor joint pain.
Dual Action Support: Acts as both a pain reliever and fever reducer for everyday comfort and wellness.
Gentle on Stomach: Contains no aspirin, providing an alternative option for those avoiding NSAIDs.
Value Size: Includes 250 extended-release caplets—ideal for home, office, or long-term use.

HealthA2Z® Pain Relief Extended Release | Acetaminophen 650mg | 8 Hours | Arthiritis Pain | Pain Reliever - Fever Reducer | Contains no Aspirin | (250 Caplets)

Why we love it

Effective Pain Management Solution.
Long-Lasting Relief with Convenience.
Ideal for Arthritis Discomfort.

Main Highlights

Long-Lasting Pain Relief: Formulated with Acetaminophen 650mg to provide up to 8 hours of relief from minor aches and pains.
Targets Multiple Discomforts: Helps temporarily relieve pain associated with arthritis, backache, headache, muscular aches, toothache, and minor joint pain.
Dual Action Support: Acts as both a pain reliever and fever reducer for everyday comfort and wellness.
Gentle on Stomach: Contains no aspirin, providing an alternative option for those avoiding NSAIDs.
Value Size: Includes 250 extended-release caplets—ideal for home, office, or long-term use.

PhysiciansCare Sinus Decongestant Congestion Medication, 2 Tablets Per Packet, Box Of 50

PhysiciansCare Sinus Decongestant Congestion Medication, 2 Tablets Per Packet, Box Of 50

PhysiciansCare

Why we love it

Effective sinus relief solution.
Convenient single-tablet packaging.
Non-drowsy, easy-to-swallow formula.

Main Highlights

Compare to the active ingredients in Sudafed PE
Coated, easy-to-swallow tablets.
50 single-tablet packets come in a perforated dispenser box for easy access.
Relieves sinus pressure and congestion.
Non-drowsy formula.

PhysiciansCare Sinus Decongestant Congestion Medication, 2 Tablets Per Packet, Box Of 50

Why we love it

Effective sinus relief solution.
Convenient single-tablet packaging.
Non-drowsy, easy-to-swallow formula.

Main Highlights

Compare to the active ingredients in Sudafed PE
Coated, easy-to-swallow tablets.
50 single-tablet packets come in a perforated dispenser box for easy access.
Relieves sinus pressure and congestion.
Non-drowsy formula.

SC Refill Extra Strength Non-Aspirin, 10x2/box

First Aid Only

Why we love it

Efficient supply organization guaranteed.
Safe and sterile packaging ensured.
Perfect for on-the-go relief.

Main Highlights

SmartCompliance Refill: Keeps first aid supplies organized and stocked efficiently.
Extra Strength Formula: Provides temporary relief for headaches, muscle aches, arthritis, toothaches, and menstrual cramps.
Tamper-Evident Packaging: Ensures safety and sterility of each dose.
Convenient & Portable: Includes 10 packets, each containing 2 tablets for easy storage and use.
Ideal for First Aid Kits: Compatible with various First Aid Only SmartCompliance cabinets.

SC Refill Extra Strength Non-Aspirin, 10x2/box

Why we love it

Efficient supply organization guaranteed.
Safe and sterile packaging ensured.
Perfect for on-the-go relief.

Main Highlights

SmartCompliance Refill: Keeps first aid supplies organized and stocked efficiently.
Extra Strength Formula: Provides temporary relief for headaches, muscle aches, arthritis, toothaches, and menstrual cramps.
Tamper-Evident Packaging: Ensures safety and sterility of each dose.
Convenient & Portable: Includes 10 packets, each containing 2 tablets for easy storage and use.
Ideal for First Aid Kits: Compatible with various First Aid Only SmartCompliance cabinets.

Medique @ Home 70433 Extra Strength APAP Tablets, Non-Aspirin, 50 Packets (2 Tablets per Packet) Total-100 Count

Medique @ Home 70433 Extra Strength APAP Tablets, Non-Aspirin, 50 Packets (2 Tablets per Packet) Total-100 Count

Medique

6% Off

Why we love it

Trusted brand for home care.
Effective pain relief solution.
User-friendly and easy to swallow.

Main Highlights

Medique @ Home the brands that work now work at home
Each tablet contains Acetaminophen 500mg
Easy to swallow film coated tablets
Compare active ingredient to Extra Strength Tylenol

Medique @ Home 70433 Extra Strength APAP Tablets, Non-Aspirin, 50 Packets (2 Tablets per Packet) Total-100 Count

6% Off

Why we love it

Trusted brand for home care.
Effective pain relief solution.
User-friendly and easy to swallow.

Main Highlights

Medique @ Home the brands that work now work at home
Each tablet contains Acetaminophen 500mg
Easy to swallow film coated tablets
Compare active ingredient to Extra Strength Tylenol

HealthA2Z® Extra Strength Pain Relief | Acetaminophen 500mg | Contains No Aspirin | Fever Reducer | Pain Reliever (500 Count (Pack of 1))

HealthA2Z® Extra Strength Pain Relief | Acetaminophen 500mg | Contains No Aspirin | Fever Reducer | Pain Reliever (500 Count (Pack of 1))

HealthA2Z

Why we love it

Fast relief for various pains.
Effective fever reduction support.
Gentle on sensitive stomachs.

Main Highlights

✅ Fast, Effective Pain Relief: Each caplet contains 500 mg of acetaminophen to relieve headaches, backaches, muscle aches, toothaches, and menstrual pain.
✅ Reduces Fever: Helps temporarily reduce fever and provide comfort during colds or flu.
✅ Gentle on Stomach: Contains no aspirin, caffeine, or ibuprofen — suitable for those with sensitive stomachs.
✅ Trusted Everyday Relief: Safe and effective when used as directed for adults and children 12 years and older.

HealthA2Z® Extra Strength Pain Relief | Acetaminophen 500mg | Contains No Aspirin | Fever Reducer | Pain Reliever (500 Count (Pack of 1))

Why we love it

Fast relief for various pains.
Effective fever reduction support.
Gentle on sensitive stomachs.

Main Highlights

✅ Fast, Effective Pain Relief: Each caplet contains 500 mg of acetaminophen to relieve headaches, backaches, muscle aches, toothaches, and menstrual pain.
✅ Reduces Fever: Helps temporarily reduce fever and provide comfort during colds or flu.
✅ Gentle on Stomach: Contains no aspirin, caffeine, or ibuprofen — suitable for those with sensitive stomachs.
✅ Trusted Everyday Relief: Safe and effective when used as directed for adults and children 12 years and older.

Globe Aspirin Tablets, 325 mg - 100 Count, Single Use Packets, NSAID Pain Relief, Pain Reliever & Fever Reducer, Arthritis Pain Relief, Headache Relief, Migraine Medicine Aspirin Pain Reliever.

Globe Aspirin Tablets, 325 mg - 100 Count, Single Use Packets, NSAID Pain Relief, Pain Reliever & Fever Reducer, Arthritis Pain Relief, Headache Relief, Migraine Medicine Aspirin Pain Reliever.

Globe

Why we love it

Regular strength for daily relief.
Pure uncoated for fast absorption.
Convenient packets for on-the-go.

Main Highlights

* REGULAR STRENGTH 325mg ASPIRIN [NSAID]: Globe Aspirin offers 325mg of pure aspirin per tablet which is the optimal amount for everyday aches and pains. Just the recommended, regular-strength dose any adult or teenager can fully benefit from. NSAID - nonsteroidal anti-inflammatory drug. Compare to the active ingredient of Bayer Aspirin.
EASY TO TAKE WITH YOU: Keep Globe Aspirin 325mg Packets in your medicine closet, first aid kit, car, camping bag, purse, kitchen drawer, kid's backpack, and even your travel carryon luggage. The convenience of these packets allows you to take them anywhere.
PAIN RELIEF: Use Aspirin to temporarily relieve minor aches and pains due to headache, muscular aches, arthritis, toothache, backache, the common cold and menstrual cramps.
* COMPARE TO: Globe Aspirin 325mg tablets are compared to Genuine Bayer Aspirin. Each Tablet contains Regular Strength Aspirin at 325 mg, offering a comparable formulation for pain relief and fever reduction at a much lower cost.
QUALITY: Manufactured in accordance with the highest pharmaceutical manufacturing processes and contains a NDC for 100% confidence. Made in the USA. Trifecta Pharmaceuticals USA is a family business based in sunny Fort Lauderdale, Florida USA.

Globe Aspirin Tablets, 325 mg - 100 Count, Single Use Packets, NSAID Pain Relief, Pain Reliever & Fever Reducer, Arthritis Pain Relief, Headache Relief, Migraine Medicine Aspirin Pain Reliever.

Why we love it

Regular strength for daily relief.
Pure uncoated for fast absorption.
Convenient packets for on-the-go.

Main Highlights

* REGULAR STRENGTH 325mg ASPIRIN [NSAID]: Globe Aspirin offers 325mg of pure aspirin per tablet which is the optimal amount for everyday aches and pains. Just the recommended, regular-strength dose any adult or teenager can fully benefit from. NSAID - nonsteroidal anti-inflammatory drug. Compare to the active ingredient of Bayer Aspirin.
EASY TO TAKE WITH YOU: Keep Globe Aspirin 325mg Packets in your medicine closet, first aid kit, car, camping bag, purse, kitchen drawer, kid's backpack, and even your travel carryon luggage. The convenience of these packets allows you to take them anywhere.
PAIN RELIEF: Use Aspirin to temporarily relieve minor aches and pains due to headache, muscular aches, arthritis, toothache, backache, the common cold and menstrual cramps.
* COMPARE TO: Globe Aspirin 325mg tablets are compared to Genuine Bayer Aspirin. Each Tablet contains Regular Strength Aspirin at 325 mg, offering a comparable formulation for pain relief and fever reduction at a much lower cost.
QUALITY: Manufactured in accordance with the highest pharmaceutical manufacturing processes and contains a NDC for 100% confidence. Made in the USA. Trifecta Pharmaceuticals USA is a family business based in sunny Fort Lauderdale, Florida USA.