10 Best Over The Counter Medication of 2026

Last updated on 02/02/2026

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Boiron Oscillococcinum for Relief from Flu-Like Symptoms of Body Aches, Headache, Fever, Chills, and Fatigue - 30 Doses

Boiron Oscillococcinum for Relief from Flu-Like Symptoms of Body Aches, Headache, Fever, Chills, and Fatigue - 30 Doses

Boiron

25% Off

Why we love it

Effective flu symptom relief.
Safe for the whole family.
Fast-dissolving, easy to take.

Main Highlights

HOMEOPATHIC FLU RELIEF: Oscillococcinum works with your body to help relieve body aches, headache, fever, chills, and fatigue.* Ideal for ages 2 and up, take at the first sign of flu-like symptoms
HOLISTIC SUPPORT: Looking for homeopathic flu relief for the whole family? Oscillococcinum’s meltaway pellets dissolve easily in the mouth; no water, chewing, or swallowing required
SHORTEN YOUR SYMPTOMS: Oscillo has been shown in clinical studies to help reduce both the duration and the severity of flu-like symptoms when taken at the onset.* Non-drowsy, easy-to-take relief
A BETTER WAY TO FEEL BETTER: Homeopathic medicines use highly diluted botanical, biological, or mineral substances to relieve symptoms. They work with your body without the risk of known drug interactions
THE BOIRON PROMISE: We believe there’s a better way to feel better. Since 1932, we’ve been dedicated to providing the purest medicines made from earth’s best resources
HSA & FSA eligible: Oscillococcinum is HSA & FSA eligible

9.8

Exceptional

9.8

Exceptional

Boiron

Boiron Oscillococcinum for Relief from Flu-Like Symptoms of Body Aches, Headache, Fever, Chills, and Fatigue - 30 Doses

25% Off

Why we love it

Effective flu symptom relief.
Safe for the whole family.
Fast-dissolving, easy to take.

Main Highlights

HOMEOPATHIC FLU RELIEF: Oscillococcinum works with your body to help relieve body aches, headache, fever, chills, and fatigue.* Ideal for ages 2 and up, take at the first sign of flu-like symptoms
HOLISTIC SUPPORT: Looking for homeopathic flu relief for the whole family? Oscillococcinum’s meltaway pellets dissolve easily in the mouth; no water, chewing, or swallowing required
SHORTEN YOUR SYMPTOMS: Oscillo has been shown in clinical studies to help reduce both the duration and the severity of flu-like symptoms when taken at the onset.* Non-drowsy, easy-to-take relief
A BETTER WAY TO FEEL BETTER: Homeopathic medicines use highly diluted botanical, biological, or mineral substances to relieve symptoms. They work with your body without the risk of known drug interactions
THE BOIRON PROMISE: We believe there’s a better way to feel better. Since 1932, we’ve been dedicated to providing the purest medicines made from earth’s best resources
HSA & FSA eligible: Oscillococcinum is HSA & FSA eligible

Value for Money

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever and Fever Reducer Medicine, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 225 Count

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever and Fever Reducer Medicine, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 225 Count

Tylenol

25% Off

Why we love it

Fast-acting relief for pain.
Gentle on the stomach.
Doctor recommended effective brand.

Main Highlights

225-count Tylenol Extra Strength Rapid Release Gels pain relief medicine with acetaminophen work fast to temporarily relieve minor aches and pains, headaches, and help reduce fever
Each pain reliever gelcap features laser-drilled holes to quickly release pain medicine and contains 500 mg of acetaminophen for fast, effective extra strength pain relief that works at the speed of life, while being gentle on the stomach
Use as a fever reducer and to relieve minor aches and pains including headache, backache, toothache, menstrual and premenstrual cramps, minor pain of arthritis, joint and muscle pain, and pain caused by the common cold and flu
With 500 mg of acetaminophen per gelcap, this extra strength oral pain reliever is fast-acting and can be used by adults and children who are 12 years and older
Experience relief of minor aches and pains with Tylenol, the #1 doctor recommended brand for pain relief and fever reduction

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever and Fever Reducer Medicine, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 225 Count

25% Off

Why we love it

Fast-acting relief for pain.
Gentle on the stomach.
Doctor recommended effective brand.

Main Highlights

225-count Tylenol Extra Strength Rapid Release Gels pain relief medicine with acetaminophen work fast to temporarily relieve minor aches and pains, headaches, and help reduce fever
Each pain reliever gelcap features laser-drilled holes to quickly release pain medicine and contains 500 mg of acetaminophen for fast, effective extra strength pain relief that works at the speed of life, while being gentle on the stomach
Use as a fever reducer and to relieve minor aches and pains including headache, backache, toothache, menstrual and premenstrual cramps, minor pain of arthritis, joint and muscle pain, and pain caused by the common cold and flu
With 500 mg of acetaminophen per gelcap, this extra strength oral pain reliever is fast-acting and can be used by adults and children who are 12 years and older
Experience relief of minor aches and pains with Tylenol, the #1 doctor recommended brand for pain relief and fever reduction

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

Vicks

5% Off

Why we love it

Day and night relief available.
Fast-acting for immediate relief.
Trusted brand for over 125 years.

Main Highlights

RELIEF YOU TRUST, DAY & NIGHT. Use non-drowsy DayQuil SEVERE for daytime relief and at night try NyQuil SEVERE for fast relief so you can rest.
POWERFUL COLD & FLU RELIEF. DayQuil and NyQuil SEVERE temporarily relieve common cold & flu symptoms
NOTHING WORKS FASTER. Just one dose starts working fast to provide effective cold & flu relief
PROVEN RELIEF FOR YOUR WORST COLD & FLU SYMPTOMS. Life doesn’t stop when you have a cold. NyQuil and DayQuil SEVERE tackle your most bothersome cold & flu symptom
WORLD'S #1 SELLING OTC COUGH AND COLD BRAND. Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms.

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

5% Off

Why we love it

Day and night relief available.
Fast-acting for immediate relief.
Trusted brand for over 125 years.

Main Highlights

RELIEF YOU TRUST, DAY & NIGHT. Use non-drowsy DayQuil SEVERE for daytime relief and at night try NyQuil SEVERE for fast relief so you can rest.
POWERFUL COLD & FLU RELIEF. DayQuil and NyQuil SEVERE temporarily relieve common cold & flu symptoms
NOTHING WORKS FASTER. Just one dose starts working fast to provide effective cold & flu relief
PROVEN RELIEF FOR YOUR WORST COLD & FLU SYMPTOMS. Life doesn’t stop when you have a cold. NyQuil and DayQuil SEVERE tackle your most bothersome cold & flu symptom
WORLD'S #1 SELLING OTC COUGH AND COLD BRAND. Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms.

Primatene Mist - Pack of 1

Primatene

17% Off

Main Highlights

Relief for Mild Symptoms of Intermittent Asthma

Primatene Mist - Pack of 1

17% Off

Main Highlights

Relief for Mild Symptoms of Intermittent Asthma

Advil Liqui-Gels minis Pain Reliever and Fever Reducer, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief - 200 Liquid Filled Capsules

Advil Liqui-Gels minis Pain Reliever and Fever Reducer, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief - 200 Liquid Filled Capsules

Advil

Why we love it

Easy to swallow for relief.
Fast absorption for tough pain.
HSA and FSA eligible product.

Main Highlights

One bottle of 200 Advil Liqui-Gels minis Pain Reliever and Fever Reducer Liquid Filled Capsules, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief
Liqui-Gel Minis are easy to swallow - the perfect addition to your college dorm room essentials
Headache medicine, back pain medicine and joint or minor arthritis pain reliever that are faster and stronger on tough pain than Tylenol Rapid Release Gels
Pain reliever and fever reducer for adults designed for fast absorption, with the same strength as regular size Advil Liqui-Gels
Fever medicine and headache pain relief, period pain relief, joint pain medicine and back pain medication for adults and children 12 years and older
Take these Advil mini Liqui-Gels as directed - the perfect addition to your college dorm room essentials
HSA and FSA eligible product

Advil Liqui-Gels minis Pain Reliever and Fever Reducer, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief - 200 Liquid Filled Capsules

Why we love it

Easy to swallow for relief.
Fast absorption for tough pain.
HSA and FSA eligible product.

Main Highlights

One bottle of 200 Advil Liqui-Gels minis Pain Reliever and Fever Reducer Liquid Filled Capsules, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief
Liqui-Gel Minis are easy to swallow - the perfect addition to your college dorm room essentials
Headache medicine, back pain medicine and joint or minor arthritis pain reliever that are faster and stronger on tough pain than Tylenol Rapid Release Gels
Pain reliever and fever reducer for adults designed for fast absorption, with the same strength as regular size Advil Liqui-Gels
Fever medicine and headache pain relief, period pain relief, joint pain medicine and back pain medication for adults and children 12 years and older
Take these Advil mini Liqui-Gels as directed - the perfect addition to your college dorm room essentials
HSA and FSA eligible product

Amazon Basic Care Ibuprofen Tablets, Fever Reducer and Pain Relief from Body Aches, Headache, Arthritis and More, 1000 Count (Packaging may vary)

Amazon Basic Care Ibuprofen Tablets, Fever Reducer and Pain Relief from Body Aches, Headache, Arthritis and More, 1000 Count (Packaging may vary)

Amazon Basic Care

Why we love it

Proven pain relief without prescription.
Strong relief for tough pain.
Effective for adults and children.

Main Highlights

ACTIVE INGREDIENT: This product contains ibuprofen 200 mg, a pain reliever and fever reducer (NSAID); compare to the active ingredient in Advil Ibuprofen Tablets
PAIN RELIEVER AND FEVER REDUCER: Proven pain relief without a prescription for tough pain such as muscular aches, minor arthritis pain, toothache, backache, menstrual cramps or minor aches and pains from the common cold; also temporarily reduces fever
STRONG RELIEF: Amazon Basic Care Ibuprofen Tablets 200 mg are strong on tough pain to help you get the relief you need to keep going; no prescription needed for this pain reliever and fever reducer
EFFECTIVE: When pain tries to take over, turn to the proven pain relief of coated Amazon Basic Care Ibuprofen Tablets 200 mg; use for adults and children 12 years and over
IBUPROFEN is the number one doctor recommended back pain OTC active ingredient (of U.S. physicians surveyed by an independent market research firm)

Amazon Basic Care Ibuprofen Tablets, Fever Reducer and Pain Relief from Body Aches, Headache, Arthritis and More, 1000 Count (Packaging may vary)

Why we love it

Proven pain relief without prescription.
Strong relief for tough pain.
Effective for adults and children.

Main Highlights

ACTIVE INGREDIENT: This product contains ibuprofen 200 mg, a pain reliever and fever reducer (NSAID); compare to the active ingredient in Advil Ibuprofen Tablets
PAIN RELIEVER AND FEVER REDUCER: Proven pain relief without a prescription for tough pain such as muscular aches, minor arthritis pain, toothache, backache, menstrual cramps or minor aches and pains from the common cold; also temporarily reduces fever
STRONG RELIEF: Amazon Basic Care Ibuprofen Tablets 200 mg are strong on tough pain to help you get the relief you need to keep going; no prescription needed for this pain reliever and fever reducer
EFFECTIVE: When pain tries to take over, turn to the proven pain relief of coated Amazon Basic Care Ibuprofen Tablets 200 mg; use for adults and children 12 years and over
IBUPROFEN is the number one doctor recommended back pain OTC active ingredient (of U.S. physicians surveyed by an independent market research firm)

Benadryl Ultratabs Allergy Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Cold & Allergy Relief of Symptoms Like Sneezing, Runny Nose, Itchy Eyes & Throat, Hay Fever, 100 Count Tablets

Benadryl Ultratabs Allergy Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Cold & Allergy Relief of Symptoms Like Sneezing, Runny Nose, Itchy Eyes & Throat, Hay Fever, 100 Count Tablets

Benadryl

25% Off

Why we love it

Powerful relief in just one pill.
Effective against multiple allergens.
Safe for adults and children.

Main Highlights

Multi-Symptom Relief: Small coated Benadryl Ultratabs with 25 mg diphenhydramine HCl provide reliable relief from sneezing, runny nose, itchy throat, and itchy, watery eyes due to hay fever or the common cold
Portable Allergy Medicine: The convenient 100-count bottle fits in backpacks, purses, or desk drawers so you can keep effective allergy medicine with you. Small, easy-to-swallow oval tablets are ideal for on-the-go allergy control
Versatile Allergy & Cold Relief: Antihistamine tablets temporarily relieve symptoms from pollen, dust, mold, pet dander, and food-reaction hives; take one tablet every four to six hours, and do not exceed six doses in any 24-hour period as directed
Active Ingredient & Age Guidance: Each Benadryl Ultratab contains 25 mg diphenhydramine HCl to help ease upper respiratory allergy symptoms; suitable for adults and children ages six and up when used exactly as directed on the product packaging
Value Pack Supply: 100-count package of allergy relief tablets helps you stay prepared for seasonal peaks and year-round triggers; compact tablets are easy to carry so relief is available at home, work, or travel whenever symptoms strike

Benadryl Ultratabs Allergy Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Cold & Allergy Relief of Symptoms Like Sneezing, Runny Nose, Itchy Eyes & Throat, Hay Fever, 100 Count Tablets

25% Off

Why we love it

Powerful relief in just one pill.
Effective against multiple allergens.
Safe for adults and children.

Main Highlights

Multi-Symptom Relief: Small coated Benadryl Ultratabs with 25 mg diphenhydramine HCl provide reliable relief from sneezing, runny nose, itchy throat, and itchy, watery eyes due to hay fever or the common cold
Portable Allergy Medicine: The convenient 100-count bottle fits in backpacks, purses, or desk drawers so you can keep effective allergy medicine with you. Small, easy-to-swallow oval tablets are ideal for on-the-go allergy control
Versatile Allergy & Cold Relief: Antihistamine tablets temporarily relieve symptoms from pollen, dust, mold, pet dander, and food-reaction hives; take one tablet every four to six hours, and do not exceed six doses in any 24-hour period as directed
Active Ingredient & Age Guidance: Each Benadryl Ultratab contains 25 mg diphenhydramine HCl to help ease upper respiratory allergy symptoms; suitable for adults and children ages six and up when used exactly as directed on the product packaging
Value Pack Supply: 100-count package of allergy relief tablets helps you stay prepared for seasonal peaks and year-round triggers; compact tablets are easy to carry so relief is available at home, work, or travel whenever symptoms strike

GoodSense Naproxen Sodium Tablets, 220 mg, 400 Count

GoodSense Naproxen Sodium Tablets, 220 mg, 400 Count

GoodSense

12% Off

Why we love it

Powerful pain relief action.
Lasts up to 12 hours.
Suitable for adults and children.

Main Highlights

ACTIVE INGREDIENT: The active ingredient in GoodSense Naproxen Sodium Tablets, 220 mg is Naproxen Sodium; Compare to Aleve Caplets active ingredient
STRENGTH TO LAST 12 HOURS: Pain reliever and fever reduction for up to 12 hours
PAIN RELIEVER: Temporarily relieves minor aches and pains due to minor pain of arthritis, muscular aches, backache, menstrual cramps, headache, toothache and the common cold; Also temporarily reduces fever
NAPROXEN SODIUM: A nonsteroidal anti-inflammatory drug (NSAID) used as a pain reliever/fever reducer
FOR ADULTS AND CHILDREN 12 YEARS AND OLDER: Children under 12 years: ask a doctor

GoodSense Naproxen Sodium Tablets, 220 mg, 400 Count

12% Off

Why we love it

Powerful pain relief action.
Lasts up to 12 hours.
Suitable for adults and children.

Main Highlights

ACTIVE INGREDIENT: The active ingredient in GoodSense Naproxen Sodium Tablets, 220 mg is Naproxen Sodium; Compare to Aleve Caplets active ingredient
STRENGTH TO LAST 12 HOURS: Pain reliever and fever reduction for up to 12 hours
PAIN RELIEVER: Temporarily relieves minor aches and pains due to minor pain of arthritis, muscular aches, backache, menstrual cramps, headache, toothache and the common cold; Also temporarily reduces fever
NAPROXEN SODIUM: A nonsteroidal anti-inflammatory drug (NSAID) used as a pain reliever/fever reducer
FOR ADULTS AND CHILDREN 12 YEARS AND OLDER: Children under 12 years: ask a doctor

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes for Fast Release, Gentle on Stomach, 500 mg Per Gelcap, 100 Count OTC Medicine

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes for Fast Release, Gentle on Stomach, 500 mg Per Gelcap, 100 Count OTC Medicine

Tylenol

25% Off

Why we love it

Fast relief from aches.
Gentle on the stomach.
Doctor recommended for pain.

Main Highlights

Fast-acting relief: Tylenol Extra Strength Rapid Release Gels feature 500 mg acetaminophen per gelcap to temporarily relieve minor aches and pains from headache, backache, arthritis, toothache, menstrual cramps, muscle aches, and fever; 100-count
Rapid-release technology: Laser-drilled holes in each gelcap release acetaminophen faster for extra strength pain relief; gelcaps are gentle on the stomach and suitable for adults and children 12 years and older
Multi-symptom support: Use as a fever reducer and to relieve headache, backache, muscle aches, arthritis pain, toothache, and joint discomfort; also helps with menstrual and premenstrual cramps and pain from the common cold or flu
Dosage instructions: Adults and children 12 years and older take two gelcaps every six hours while symptoms last; do not exceed six gelcaps in 24 hours; always follow the label directions for safe use of acetaminophen and dosing guidance
Doctor-recommended brand: Choose Tylenol, the #1 doctor-recommended brand for pain relief and fever reduction based on 2021 IQVIA survey; over-the-counter medication with 500 mg acetaminophen per gelcap that’s gentle on the stomach

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes for Fast Release, Gentle on Stomach, 500 mg Per Gelcap, 100 Count OTC Medicine

25% Off

Why we love it

Fast relief from aches.
Gentle on the stomach.
Doctor recommended for pain.

Main Highlights

Fast-acting relief: Tylenol Extra Strength Rapid Release Gels feature 500 mg acetaminophen per gelcap to temporarily relieve minor aches and pains from headache, backache, arthritis, toothache, menstrual cramps, muscle aches, and fever; 100-count
Rapid-release technology: Laser-drilled holes in each gelcap release acetaminophen faster for extra strength pain relief; gelcaps are gentle on the stomach and suitable for adults and children 12 years and older
Multi-symptom support: Use as a fever reducer and to relieve headache, backache, muscle aches, arthritis pain, toothache, and joint discomfort; also helps with menstrual and premenstrual cramps and pain from the common cold or flu
Dosage instructions: Adults and children 12 years and older take two gelcaps every six hours while symptoms last; do not exceed six gelcaps in 24 hours; always follow the label directions for safe use of acetaminophen and dosing guidance
Doctor-recommended brand: Choose Tylenol, the #1 doctor-recommended brand for pain relief and fever reduction based on 2021 IQVIA survey; over-the-counter medication with 500 mg acetaminophen per gelcap that’s gentle on the stomach

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)

Amazon Basic Care

Why we love it

Effective pain relief solution.
Trusted active ingredient Acetaminophen.
Convenient for everyday use.

Main Highlights

ACTIVE INGREDIENT: Amazon Basic Care Extra Strength Pain Relief's active ingredient is Acetaminophen, 500 mg, which compares to the active ingredient of Extra Strength Tylenol CapletsAmazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, temporarily relieves minor aches and pains due to: the common cold, headache, backache, minor pain of arthritis, toothache, muscular aches, and premenstrual and menstrual cramps also temporarily reduces fever
USE: Acetaminophen may be used as a pain reliever and fever reducer for adults and children 12 years and over
PAIN: Pain may begin with an injury or illness, but could also originate with anything from a bad mattress to arthritisACUTE PAIN: Acute pain acts as an alarm such as with a bee sting or stubbing your toe and can last for a few moments or for longer
Product may be manufactured in India or U.S.

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)

Why we love it

Effective pain relief solution.
Trusted active ingredient Acetaminophen.
Convenient for everyday use.

Main Highlights

ACTIVE INGREDIENT: Amazon Basic Care Extra Strength Pain Relief's active ingredient is Acetaminophen, 500 mg, which compares to the active ingredient of Extra Strength Tylenol CapletsAmazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, temporarily relieves minor aches and pains due to: the common cold, headache, backache, minor pain of arthritis, toothache, muscular aches, and premenstrual and menstrual cramps also temporarily reduces fever
USE: Acetaminophen may be used as a pain reliever and fever reducer for adults and children 12 years and over
PAIN: Pain may begin with an injury or illness, but could also originate with anything from a bad mattress to arthritisACUTE PAIN: Acute pain acts as an alarm such as with a bee sting or stubbing your toe and can last for a few moments or for longer
Product may be manufactured in India or U.S.