10 Best Over The Counter Medication of 2025

Last updated on 12/18/2025

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Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

Abreva

21% OffFree Shipping

Why we love it

Quick healing for cold sores.
Clinically proven to reduce symptoms.
Convenient for on-the-go use.

Main Highlights

Number 1 Cold Sore Brand: Two 0.07 oz tubes of Abreva 10 Percent Docosanol Cold Sore Treatment
Can Heal in 2.5 Days: Fever blister cream contains 10 percent docosanol to shorten the duration of cold sore symptoms (1)
Nothing Heals Fever Blisters Faster: 10 percent docosanol cream penetrates deep into skin to tackle cold sores at their source (1, 2, 3)
Lip Cream Clinically Proven to Shorten Duration of Symptoms: Cold sore product shortens duration of tingling, pain, burning and itching associated with cold sores (1)
Portable Cold Sore Cream: Packaged in a convenient tube for on the go cold sore treatment
Number 1 Dermatologist Recommended Cold Sore Treatment: Abreva Cream is a nonprescription cold sore medicine that shortens healing time (1)
HSA and FSA eligible product

9.8

Exceptional

9.8

Exceptional

Abreva

Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

21% OffFree Shipping

Why we love it

Quick healing for cold sores.
Clinically proven to reduce symptoms.
Convenient for on-the-go use.

Main Highlights

Number 1 Cold Sore Brand: Two 0.07 oz tubes of Abreva 10 Percent Docosanol Cold Sore Treatment
Can Heal in 2.5 Days: Fever blister cream contains 10 percent docosanol to shorten the duration of cold sore symptoms (1)
Nothing Heals Fever Blisters Faster: 10 percent docosanol cream penetrates deep into skin to tackle cold sores at their source (1, 2, 3)
Lip Cream Clinically Proven to Shorten Duration of Symptoms: Cold sore product shortens duration of tingling, pain, burning and itching associated with cold sores (1)
Portable Cold Sore Cream: Packaged in a convenient tube for on the go cold sore treatment
Number 1 Dermatologist Recommended Cold Sore Treatment: Abreva Cream is a nonprescription cold sore medicine that shortens healing time (1)
HSA and FSA eligible product

Value for Money

Advil Liqui-Gels minis Pain Reliever and Fever Reducer, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief - 200 Liquid Filled Capsules

Advil Liqui-Gels minis Pain Reliever and Fever Reducer, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief - 200 Liquid Filled Capsules

Advil

Free Shipping

Why we love it

Easy to swallow for relief.
Fast absorption for tough pain.
HSA and FSA eligible product.

Main Highlights

One bottle of 200 Advil Liqui-Gels minis Pain Reliever and Fever Reducer Liquid Filled Capsules, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief
Liqui-Gel Minis are easy to swallow - the perfect addition to your college dorm room essentials
Headache medicine, back pain medicine and joint or minor arthritis pain reliever that are faster and stronger on tough pain than Tylenol Rapid Release Gels
Pain reliever and fever reducer for adults designed for fast absorption, with the same strength as regular size Advil Liqui-Gels
Fever medicine and headache pain relief, period pain relief, joint pain medicine and back pain medication for adults and children 12 years and older
Take these Advil mini Liqui-Gels as directed - the perfect addition to your college dorm room essentials
HSA and FSA eligible product

Advil Liqui-Gels minis Pain Reliever and Fever Reducer, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief - 200 Liquid Filled Capsules

Free Shipping

Why we love it

Easy to swallow for relief.
Fast absorption for tough pain.
HSA and FSA eligible product.

Main Highlights

One bottle of 200 Advil Liqui-Gels minis Pain Reliever and Fever Reducer Liquid Filled Capsules, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief
Liqui-Gel Minis are easy to swallow - the perfect addition to your college dorm room essentials
Headache medicine, back pain medicine and joint or minor arthritis pain reliever that are faster and stronger on tough pain than Tylenol Rapid Release Gels
Pain reliever and fever reducer for adults designed for fast absorption, with the same strength as regular size Advil Liqui-Gels
Fever medicine and headache pain relief, period pain relief, joint pain medicine and back pain medication for adults and children 12 years and older
Take these Advil mini Liqui-Gels as directed - the perfect addition to your college dorm room essentials
HSA and FSA eligible product

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever and Fever Reducer Medicine, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 225 Count

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever and Fever Reducer Medicine, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 225 Count

Tylenol

25% OffFree Shipping

Why we love it

Fast-acting relief for pain.
Gentle on the stomach.
Doctor recommended effective brand.

Main Highlights

225-count Tylenol Extra Strength Rapid Release Gels pain relief medicine with acetaminophen work fast to temporarily relieve minor aches and pains, headaches, and help reduce fever
Each pain reliever gelcap features laser-drilled holes to quickly release pain medicine and contains 500 mg of acetaminophen for fast, effective extra strength pain relief that works at the speed of life, while being gentle on the stomach
Use as a fever reducer and to relieve minor aches and pains including headache, backache, toothache, menstrual and premenstrual cramps, minor pain of arthritis, joint and muscle pain, and pain caused by the common cold and flu
With 500 mg of acetaminophen per gelcap, this extra strength oral pain reliever is fast-acting and can be used by adults and children who are 12 years and older
Experience relief of minor aches and pains with Tylenol, the #1 doctor recommended brand for pain relief and fever reduction

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever and Fever Reducer Medicine, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 225 Count

25% OffFree Shipping

Why we love it

Fast-acting relief for pain.
Gentle on the stomach.
Doctor recommended effective brand.

Main Highlights

225-count Tylenol Extra Strength Rapid Release Gels pain relief medicine with acetaminophen work fast to temporarily relieve minor aches and pains, headaches, and help reduce fever
Each pain reliever gelcap features laser-drilled holes to quickly release pain medicine and contains 500 mg of acetaminophen for fast, effective extra strength pain relief that works at the speed of life, while being gentle on the stomach
Use as a fever reducer and to relieve minor aches and pains including headache, backache, toothache, menstrual and premenstrual cramps, minor pain of arthritis, joint and muscle pain, and pain caused by the common cold and flu
With 500 mg of acetaminophen per gelcap, this extra strength oral pain reliever is fast-acting and can be used by adults and children who are 12 years and older
Experience relief of minor aches and pains with Tylenol, the #1 doctor recommended brand for pain relief and fever reduction

Aleve Back & Muscle Pain Relief Naproxen Sodium Tablets, Pain Reliever & Fever Reducer, Medicine for Body , 250 Count

Aleve Back & Muscle Pain Relief Naproxen Sodium Tablets, Pain Reliever & Fever Reducer, Medicine for Body , 250 Count

Aleve

Free Shipping

Why we love it

Long-lasting pain relief formula.
Reduces fever effectively.
Easy-to-swallow tablet size.

Main Highlights

Up to 12-Hours of Uninterrupted Pain Relief: Aleve Back & Muscle Pain Relief Tablets provide long-lasting back pain and muscle pain relief
Fever Reducer: Temporarily reduces fever for adults and children aged 12 and up
Targeted Pain Relief: Every tablet is made with 220 mg of naproxen sodium to help you take on muscle pain and provide back pain relief
Effective Pain Reliever: In a study, proven as effective and longer lasting than a common Rx pain reliever. Ask a doctor if Aleve is right for you
Comes in small, easy-to-swallow tablets; use as directed

Aleve Back & Muscle Pain Relief Naproxen Sodium Tablets, Pain Reliever & Fever Reducer, Medicine for Body , 250 Count

Free Shipping

Why we love it

Long-lasting pain relief formula.
Reduces fever effectively.
Easy-to-swallow tablet size.

Main Highlights

Up to 12-Hours of Uninterrupted Pain Relief: Aleve Back & Muscle Pain Relief Tablets provide long-lasting back pain and muscle pain relief
Fever Reducer: Temporarily reduces fever for adults and children aged 12 and up
Targeted Pain Relief: Every tablet is made with 220 mg of naproxen sodium to help you take on muscle pain and provide back pain relief
Effective Pain Reliever: In a study, proven as effective and longer lasting than a common Rx pain reliever. Ask a doctor if Aleve is right for you
Comes in small, easy-to-swallow tablets; use as directed

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

Vicks

9% OffFree Shipping

Why we love it

Day and night relief available.
Fast-acting for immediate relief.
Trusted brand for over 125 years.

Main Highlights

RELIEF YOU TRUST, DAY & NIGHT. Use non-drowsy DayQuil SEVERE for daytime relief and at night try NyQuil SEVERE for fast relief so you can rest.
POWERFUL COLD & FLU RELIEF. DayQuil and NyQuil SEVERE temporarily relieve common cold & flu symptoms
NOTHING WORKS FASTER. Just one dose starts working fast to provide effective cold & flu relief
PROVEN RELIEF FOR YOUR WORST COLD & FLU SYMPTOMS. Life doesn’t stop when you have a cold. NyQuil and DayQuil SEVERE tackle your most bothersome cold & flu symptom
WORLD'S #1 SELLING OTC COUGH AND COLD BRAND. Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms.

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

9% OffFree Shipping

Why we love it

Day and night relief available.
Fast-acting for immediate relief.
Trusted brand for over 125 years.

Main Highlights

RELIEF YOU TRUST, DAY & NIGHT. Use non-drowsy DayQuil SEVERE for daytime relief and at night try NyQuil SEVERE for fast relief so you can rest.
POWERFUL COLD & FLU RELIEF. DayQuil and NyQuil SEVERE temporarily relieve common cold & flu symptoms
NOTHING WORKS FASTER. Just one dose starts working fast to provide effective cold & flu relief
PROVEN RELIEF FOR YOUR WORST COLD & FLU SYMPTOMS. Life doesn’t stop when you have a cold. NyQuil and DayQuil SEVERE tackle your most bothersome cold & flu symptom
WORLD'S #1 SELLING OTC COUGH AND COLD BRAND. Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms.

Mucinex Rapid Clear Maximum Strength Cold Medicine & Expectorant, Fever, Pain, Headache, & Excess Mucus Relief with Acetaminophen & Guaifenesin, Rapid Release Caplets for Adults, 20 Count

Mucinex Rapid Clear Maximum Strength Cold Medicine & Expectorant, Fever, Pain, Headache, & Excess Mucus Relief with Acetaminophen & Guaifenesin, Rapid Release Caplets for Adults, 20 Count

Mucinex

Free Shipping

Why we love it

Fast-acting pain relief.
Effective mucus congestion relief.
Trusted cold medicine for adults.

Main Highlights

PAIN RELIEF: Acetaminophen helps reduce fever and helps relieve body aches and headache associated with cold and flu
EXCESS MUCUS RELIEF: The expectorant, Guaifenesin, provides effective excess mucus relief by thinning and loosening bothersome mucus in your chest, helping to clear chest congestion
COLD MEDICINE: Mucinex Rapid Clear Pain, Headache, & Mucus Congestion is a trusted cold medicine for adults, offering comprehensive relief from cold and flu symptoms including fever, body pain, sore throat, headache, and excess mucus
HEADACHE RELIEF: Helps relieve headaches including those associated with cold and flu
EXPECTORANT: Contains Guaifenesin, an expectorant that aids in thinning and loosening mucus for more productive coughs and chest congestion relief
RAPID RELEASE CAPLETS: Mucinex Rapid Clear caplets start working fast
MAXIMUM STRENGTH & NON-DROWSY: With Mucinex Rapid Clear, it's not "power through with a pounding headache" season—It's comeback season

Mucinex Rapid Clear Maximum Strength Cold Medicine & Expectorant, Fever, Pain, Headache, & Excess Mucus Relief with Acetaminophen & Guaifenesin, Rapid Release Caplets for Adults, 20 Count

Free Shipping

Why we love it

Fast-acting pain relief.
Effective mucus congestion relief.
Trusted cold medicine for adults.

Main Highlights

PAIN RELIEF: Acetaminophen helps reduce fever and helps relieve body aches and headache associated with cold and flu
EXCESS MUCUS RELIEF: The expectorant, Guaifenesin, provides effective excess mucus relief by thinning and loosening bothersome mucus in your chest, helping to clear chest congestion
COLD MEDICINE: Mucinex Rapid Clear Pain, Headache, & Mucus Congestion is a trusted cold medicine for adults, offering comprehensive relief from cold and flu symptoms including fever, body pain, sore throat, headache, and excess mucus
HEADACHE RELIEF: Helps relieve headaches including those associated with cold and flu
EXPECTORANT: Contains Guaifenesin, an expectorant that aids in thinning and loosening mucus for more productive coughs and chest congestion relief
RAPID RELEASE CAPLETS: Mucinex Rapid Clear caplets start working fast
MAXIMUM STRENGTH & NON-DROWSY: With Mucinex Rapid Clear, it's not "power through with a pounding headache" season—It's comeback season

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 1000 Count (Packaging may vary)

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 1000 Count (Packaging may vary)

Amazon Basic Care

Free Shipping

Why we love it

Effective relief for various pains.
Trusted active ingredient: Acetaminophen.
Convenient for adults and children.

Main Highlights

ACTIVE INGREDIENT: Amazon Basic Care Extra Strength Pain Relief's active ingredient is Acetaminophen, 500 mg, which compares to the active ingredient of Extra Strength Tylenol CapletsAmazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, temporarily relieves minor aches and pains due to: the common cold, headache, backache, minor pain of arthritis, toothache, muscular aches, and premenstrual and menstrual cramps also temporarily reduces fever
USE: Acetaminophen may be used as a pain reliever and fever reducer for adults and children 12 years and over
PAIN: Pain may begin with an injury or illness, but could also originate with anything from a bad mattress to arthritisACUTE PAIN: Acute pain acts as an alarm such as with a bee sting or stubbing your toe and can last for a few moments or for longer
"Product may be manufactured in India or U.S."

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 1000 Count (Packaging may vary)

Free Shipping

Why we love it

Effective relief for various pains.
Trusted active ingredient: Acetaminophen.
Convenient for adults and children.

Main Highlights

ACTIVE INGREDIENT: Amazon Basic Care Extra Strength Pain Relief's active ingredient is Acetaminophen, 500 mg, which compares to the active ingredient of Extra Strength Tylenol CapletsAmazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, temporarily relieves minor aches and pains due to: the common cold, headache, backache, minor pain of arthritis, toothache, muscular aches, and premenstrual and menstrual cramps also temporarily reduces fever
USE: Acetaminophen may be used as a pain reliever and fever reducer for adults and children 12 years and over
PAIN: Pain may begin with an injury or illness, but could also originate with anything from a bad mattress to arthritisACUTE PAIN: Acute pain acts as an alarm such as with a bee sting or stubbing your toe and can last for a few moments or for longer
"Product may be manufactured in India or U.S."

Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms - 200 Count

Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms - 200 Count

Excedrin

Free Shipping

Why we love it

Fast-acting migraine relief.
Triple action formula technology.
Convenient and easy to take.

Main Highlights

One bottle of 2 Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms
Excedrin Migraine works in 3 ways to relieve migraines: it blocks pain signals, elevates your pain threshold and uses caffeine to enhance the pain relief effect
Delivers migraine relief, including acting as a migraine headache pain reliever and relieving sensitivity to light and sound, and nausea
Excedrin migraine pain relief caplets combine acetaminophen, aspirin and caffeine
Head pain relief medicine delivers a powerful triple action formula with two pain relievers and an amplifier

Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms - 200 Count

Free Shipping

Why we love it

Fast-acting migraine relief.
Triple action formula technology.
Convenient and easy to take.

Main Highlights

One bottle of 2 Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms
Excedrin Migraine works in 3 ways to relieve migraines: it blocks pain signals, elevates your pain threshold and uses caffeine to enhance the pain relief effect
Delivers migraine relief, including acting as a migraine headache pain reliever and relieving sensitivity to light and sound, and nausea
Excedrin migraine pain relief caplets combine acetaminophen, aspirin and caffeine
Head pain relief medicine delivers a powerful triple action formula with two pain relievers and an amplifier

Amazon Basic Care Ibuprofen Tablets 200 mg, Pain Reliever/Fever Reducer, Body Aches, Headache, Arthritis Pain Relief and More, 500 Count (Packaging may vary)

Amazon Basic Care Ibuprofen Tablets 200 mg, Pain Reliever/Fever Reducer, Body Aches, Headache, Arthritis Pain Relief and More, 500 Count (Packaging may vary)

Amazon Basic Care

Free Shipping

Why we love it

Strong pain relief when needed.
No prescription required for effectiveness.
Doctor recommended for back pain.

Main Highlights

ACTIVE INGREDIENT: This product contains ibuprofen 200 mg, a pain reliever and fever reducer (NSAID); compare to the active ingredient in Advil Ibuprofen TabletsPAIN RELIEVER AND FEVER REDUCER: Proven pain relief without a prescription for tough pain such as muscular aches, minor arthritis pain, toothache, backache, menstrual cramps or minor aches and pains from the common cold; also temporarily reduces fever
STRONG RELIEF: Amazon Basic Care Ibuprofen Tablets 200 mg are strong on tough pain to help you get the relief you need to keep going; no prescription needed for this pain reliever and fever reducerEFFECTIVE: When pain tries to take over, turn to the proven pain relief of coated Amazon Basic Care Ibuprofen Tablets 200 mg; use for adults and children 12 years and over
IBUPROFEN is the number one doctor recommended back pain OTC active ingredient (of U.S. physicians surveyed by an independent market research firm)
Product may be manufactured in India or U.S.

Amazon Basic Care Ibuprofen Tablets 200 mg, Pain Reliever/Fever Reducer, Body Aches, Headache, Arthritis Pain Relief and More, 500 Count (Packaging may vary)

Free Shipping

Why we love it

Strong pain relief when needed.
No prescription required for effectiveness.
Doctor recommended for back pain.

Main Highlights

ACTIVE INGREDIENT: This product contains ibuprofen 200 mg, a pain reliever and fever reducer (NSAID); compare to the active ingredient in Advil Ibuprofen TabletsPAIN RELIEVER AND FEVER REDUCER: Proven pain relief without a prescription for tough pain such as muscular aches, minor arthritis pain, toothache, backache, menstrual cramps or minor aches and pains from the common cold; also temporarily reduces fever
STRONG RELIEF: Amazon Basic Care Ibuprofen Tablets 200 mg are strong on tough pain to help you get the relief you need to keep going; no prescription needed for this pain reliever and fever reducerEFFECTIVE: When pain tries to take over, turn to the proven pain relief of coated Amazon Basic Care Ibuprofen Tablets 200 mg; use for adults and children 12 years and over
IBUPROFEN is the number one doctor recommended back pain OTC active ingredient (of U.S. physicians surveyed by an independent market research firm)
Product may be manufactured in India or U.S.

Tylenol Extra Strength Pain Relief Pills, Acetaminophen 500mg Caplets, Pain Reliever and Fever Reducer Medicine for Headache, Backache, Toothache & Minor Arthritis, 100 Count Bottle

Tylenol Extra Strength Pain Relief Pills, Acetaminophen 500mg Caplets, Pain Reliever and Fever Reducer Medicine for Headache, Backache, Toothache & Minor Arthritis, 100 Count Bottle

Tylenol

9% OffFree Shipping

Why we love it

Fast relief for minor aches.
Reliable fever reducer option.
Doctor recommended for safety.

Main Highlights

Convenient packaging: choose a 100-count bottle or 50 travel pouches of 2 coated caplets for on-the-go pain relief pills; portable design fits purses, backpacks and luggage for quick access whenever and wherever you need relief.
Extra strength relief: each coated caplet contains acetaminophen 500mg to temporarily relieve headache, backache, toothache, minor arthritis pain and muscular aches; take two every 6 hours; do not exceed six caplets in 24 hours.
Pain reliever and fever reducer: acetaminophen temporarily reduces fever and relieves aches due to the common cold, menstrual cramps, muscular soreness and everyday aches, providing broad comfort for adults; always use as directed on the label.
Non-aspirin formula: coated caplets have an excellent safety profile when used as directed; suitable for adults and children 12 years and older for relief of common pains and fever reduction. (225 characters)
Trusted brand: from Tylenol, Extra Strength Caplets deliver reliable, consistent results you can count on for everyday aches and fever when used as directed.

Tylenol Extra Strength Pain Relief Pills, Acetaminophen 500mg Caplets, Pain Reliever and Fever Reducer Medicine for Headache, Backache, Toothache & Minor Arthritis, 100 Count Bottle

9% OffFree Shipping

Why we love it

Fast relief for minor aches.
Reliable fever reducer option.
Doctor recommended for safety.

Main Highlights

Convenient packaging: choose a 100-count bottle or 50 travel pouches of 2 coated caplets for on-the-go pain relief pills; portable design fits purses, backpacks and luggage for quick access whenever and wherever you need relief.
Extra strength relief: each coated caplet contains acetaminophen 500mg to temporarily relieve headache, backache, toothache, minor arthritis pain and muscular aches; take two every 6 hours; do not exceed six caplets in 24 hours.
Pain reliever and fever reducer: acetaminophen temporarily reduces fever and relieves aches due to the common cold, menstrual cramps, muscular soreness and everyday aches, providing broad comfort for adults; always use as directed on the label.
Non-aspirin formula: coated caplets have an excellent safety profile when used as directed; suitable for adults and children 12 years and older for relief of common pains and fever reduction. (225 characters)
Trusted brand: from Tylenol, Extra Strength Caplets deliver reliable, consistent results you can count on for everyday aches and fever when used as directed.