10 Best Over The Counter Medication of 2025

Last updated on 09/30/2025

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Best Choice

Primatene Mist - Pack of 1

Primatene

8% OffFree Shipping

Main Highlights

Relief for Mild Symptoms of Intermittent Asthma

9.8

Exceptional

9.8

Exceptional

Primatene

Primatene Mist - Pack of 1

8% OffFree Shipping

Main Highlights

Relief for Mild Symptoms of Intermittent Asthma

Value for Money

Vicks DayQuil & NyQuil Co-Pack, Cold & Flu Medicine, Powerful Multi-Symptom Daytime & Nighttime Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, & Cough, 72ct

Vicks DayQuil & NyQuil Co-Pack, Cold & Flu Medicine, Powerful Multi-Symptom Daytime & Nighttime Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, & Cough, 72ct

Vicks

Free Shipping

Why we love it

Fast, powerful symptom relief.
Effective cold and flu remedy.
Trusted brand for generations.

Main Highlights

FAST, POWERFUL MULTI-SYMPTOM RELIEF. Use non-drowsy DayQuil for daytime relief and at night try NyQuil for fast relief so you can rest.
EFFECTIVE COLD & FLU SYMPTOM RELIEF. DayQuil and NyQuil Cold & Flu medicine temporarily relieve common cold & flu symptoms
FEEL BETTER FAST. Just one dose starts working fast to provide effective cold & flu relief
POWER THROUGH YOUR WORST COLD & FLU SYMPTOMS. Life doesn’t stop when you have a cold. DayQuil and NyQuil relieve bothersome symptoms, such as cough and fever, day or night.
WORLD'S #1 SELLING OTC COUGH AND COLD BRAND. Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms.

Vicks DayQuil & NyQuil Co-Pack, Cold & Flu Medicine, Powerful Multi-Symptom Daytime & Nighttime Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, & Cough, 72ct

Free Shipping

Why we love it

Fast, powerful symptom relief.
Effective cold and flu remedy.
Trusted brand for generations.

Main Highlights

FAST, POWERFUL MULTI-SYMPTOM RELIEF. Use non-drowsy DayQuil for daytime relief and at night try NyQuil for fast relief so you can rest.
EFFECTIVE COLD & FLU SYMPTOM RELIEF. DayQuil and NyQuil Cold & Flu medicine temporarily relieve common cold & flu symptoms
FEEL BETTER FAST. Just one dose starts working fast to provide effective cold & flu relief
POWER THROUGH YOUR WORST COLD & FLU SYMPTOMS. Life doesn’t stop when you have a cold. DayQuil and NyQuil relieve bothersome symptoms, such as cough and fever, day or night.
WORLD'S #1 SELLING OTC COUGH AND COLD BRAND. Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms.

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

Vicks

Free Shipping

Why we love it

Day and night relief available.
Fast-acting for immediate relief.
Trusted brand for over 125 years.

Main Highlights

RELIEF YOU TRUST, DAY & NIGHT. Use non-drowsy DayQuil SEVERE for daytime relief and at night try NyQuil SEVERE for fast relief so you can rest.
POWERFUL COLD & FLU RELIEF. DayQuil and NyQuil SEVERE temporarily relieve common cold & flu symptoms
NOTHING WORKS FASTER. Just one dose starts working fast to provide effective cold & flu relief
PROVEN RELIEF FOR YOUR WORST COLD & FLU SYMPTOMS. Life doesn’t stop when you have a cold. NyQuil and DayQuil SEVERE tackle your most bothersome cold & flu symptom
WORLD'S #1 SELLING OTC COUGH AND COLD BRAND. Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms.

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

Free Shipping

Why we love it

Day and night relief available.
Fast-acting for immediate relief.
Trusted brand for over 125 years.

Main Highlights

RELIEF YOU TRUST, DAY & NIGHT. Use non-drowsy DayQuil SEVERE for daytime relief and at night try NyQuil SEVERE for fast relief so you can rest.
POWERFUL COLD & FLU RELIEF. DayQuil and NyQuil SEVERE temporarily relieve common cold & flu symptoms
NOTHING WORKS FASTER. Just one dose starts working fast to provide effective cold & flu relief
PROVEN RELIEF FOR YOUR WORST COLD & FLU SYMPTOMS. Life doesn’t stop when you have a cold. NyQuil and DayQuil SEVERE tackle your most bothersome cold & flu symptom
WORLD'S #1 SELLING OTC COUGH AND COLD BRAND. Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms.

Advil Liqui-Gels minis Pain Reliever and Fever Reducer, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief - 200 Liquid Filled Capsules

Advil Liqui-Gels minis Pain Reliever and Fever Reducer, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief - 200 Liquid Filled Capsules

Advil

7% OffFree Shipping

Why we love it

Easy to swallow for relief.
Fast absorption for tough pain.
HSA and FSA eligible product.

Main Highlights

One bottle of 200 Advil Liqui-Gels minis Pain Reliever and Fever Reducer Liquid Filled Capsules, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief
Liqui-Gel Minis are easy to swallow - the perfect addition to your college dorm room essentials
Headache medicine, back pain medicine and joint or minor arthritis pain reliever that are faster and stronger on tough pain than Tylenol Rapid Release Gels
Pain reliever and fever reducer for adults designed for fast absorption, with the same strength as regular size Advil Liqui-Gels
Fever medicine and headache pain relief, period pain relief, joint pain medicine and back pain medication for adults and children 12 years and older
Take these Advil mini Liqui-Gels as directed - the perfect addition to your college dorm room essentials
HSA and FSA eligible product

Advil Liqui-Gels minis Pain Reliever and Fever Reducer, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief - 200 Liquid Filled Capsules

7% OffFree Shipping

Why we love it

Easy to swallow for relief.
Fast absorption for tough pain.
HSA and FSA eligible product.

Main Highlights

One bottle of 200 Advil Liqui-Gels minis Pain Reliever and Fever Reducer Liquid Filled Capsules, Pain Medicine for Adults with Ibuprofen 200mg for Pain Relief
Liqui-Gel Minis are easy to swallow - the perfect addition to your college dorm room essentials
Headache medicine, back pain medicine and joint or minor arthritis pain reliever that are faster and stronger on tough pain than Tylenol Rapid Release Gels
Pain reliever and fever reducer for adults designed for fast absorption, with the same strength as regular size Advil Liqui-Gels
Fever medicine and headache pain relief, period pain relief, joint pain medicine and back pain medication for adults and children 12 years and older
Take these Advil mini Liqui-Gels as directed - the perfect addition to your college dorm room essentials
HSA and FSA eligible product

WELMATE - Urinary Pain Relief (72 Tablets) - Phenazopyridine Hydrochloride 99.5mg - Urinary Pain, Urgency, & Discomfort - Maximum Strength - Over-The-Counter Medication

WELMATE - Urinary Pain Relief (72 Tablets) - Phenazopyridine Hydrochloride 99.5mg - Urinary Pain, Urgency, & Discomfort - Maximum Strength - Over-The-Counter Medication

WELMATE

15% OffFree Shipping

Why we love it

Fast-acting relief from discomfort.
Supports urinary tract health.
Doctor recommended for effectiveness.

Main Highlights

Fast Acting Urinary Tract Relief – Phenazopyridine Hydrochloride 99.5mg is the #1 doctor and pharmacist-recommended OTC ingredient for UTI pain, specifically for urinary discomfort.
Maximum Strength – Delivers the same active ingredient and dosage as AZO Urinary Pain Relief, 99.5mg Phenazopyridine Hydrochloride. Includes 72 tablets.
Quick Relief & Support – Immediately targets the site of discomfort, soothing the urinary tract, and providing relief within minutes. Symptoms can be caused by injury, surgery, a catheter, or irritation of the bladder.
How to Use – Adults & Children (12yrs & older), take 2 tablets 3 times daily with or after meals as needed for up to two days. Take with a full glass of water. DO NOT use for more than 2 days (12 tablets) without consulting a doctor.
Why WELMATE? - Founded in 2020 by former pharmacy employees who were fed up with the pricing of over-the-counter medication. Today, we continue to bring affordable health and wellness products to your doorstep as America's trusted OTC store.

WELMATE - Urinary Pain Relief (72 Tablets) - Phenazopyridine Hydrochloride 99.5mg - Urinary Pain, Urgency, & Discomfort - Maximum Strength - Over-The-Counter Medication

15% OffFree Shipping

Why we love it

Fast-acting relief from discomfort.
Supports urinary tract health.
Doctor recommended for effectiveness.

Main Highlights

Fast Acting Urinary Tract Relief – Phenazopyridine Hydrochloride 99.5mg is the #1 doctor and pharmacist-recommended OTC ingredient for UTI pain, specifically for urinary discomfort.
Maximum Strength – Delivers the same active ingredient and dosage as AZO Urinary Pain Relief, 99.5mg Phenazopyridine Hydrochloride. Includes 72 tablets.
Quick Relief & Support – Immediately targets the site of discomfort, soothing the urinary tract, and providing relief within minutes. Symptoms can be caused by injury, surgery, a catheter, or irritation of the bladder.
How to Use – Adults & Children (12yrs & older), take 2 tablets 3 times daily with or after meals as needed for up to two days. Take with a full glass of water. DO NOT use for more than 2 days (12 tablets) without consulting a doctor.
Why WELMATE? - Founded in 2020 by former pharmacy employees who were fed up with the pricing of over-the-counter medication. Today, we continue to bring affordable health and wellness products to your doorstep as America's trusted OTC store.

Amazon Basic Care Ibuprofen Tablets, 200 mg, Pain Reliever/Fever Reducer, 500 Count

Amazon Basic Care Ibuprofen Tablets, 200 mg, Pain Reliever/Fever Reducer, 500 Count

Amazon Basic Care

15% OffFree Shipping

Why we love it

Effective pain relief solution.
Gluten free for everyone.
Approved for ages 12+.

Main Highlights

ACTIVE INGREDIENT: This pain reliever and fever reducer contains 200 mg of ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID); compare to Motrin IB active ingredient
RELIEF FOR ACHES AND PAINS: Amazon Basic Care Ibuprofen Tablets temporarily relieve minor aches and pains due to headache, muscular ache, minor pain of arthritis, toothache, backache, the common cold and menstrual cramps; also temporarily reduces fever
COATED CAPLETS: These orange coated caplets (capsule-shaped tablets) are a gluten free choice to relieve minor body aches and pains and temporarily reduce fever; each caplet contains 200 mg of ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID)
APPROVED FOR ADULTS AND CHILDREN AGE 12 AND OVER: Use Amazon Basic Care Ibuprofen Tablets for adults and children age 12 years and over; children under 12 years: ask a doctor
GLUTEN FREE: This product is gluten free; package is child resistant

Amazon Basic Care Ibuprofen Tablets, 200 mg, Pain Reliever/Fever Reducer, 500 Count

15% OffFree Shipping

Why we love it

Effective pain relief solution.
Gluten free for everyone.
Approved for ages 12+.

Main Highlights

ACTIVE INGREDIENT: This pain reliever and fever reducer contains 200 mg of ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID); compare to Motrin IB active ingredient
RELIEF FOR ACHES AND PAINS: Amazon Basic Care Ibuprofen Tablets temporarily relieve minor aches and pains due to headache, muscular ache, minor pain of arthritis, toothache, backache, the common cold and menstrual cramps; also temporarily reduces fever
COATED CAPLETS: These orange coated caplets (capsule-shaped tablets) are a gluten free choice to relieve minor body aches and pains and temporarily reduce fever; each caplet contains 200 mg of ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID)
APPROVED FOR ADULTS AND CHILDREN AGE 12 AND OVER: Use Amazon Basic Care Ibuprofen Tablets for adults and children age 12 years and over; children under 12 years: ask a doctor
GLUTEN FREE: This product is gluten free; package is child resistant

HealthA2Z® Ibuprofen 200mg | 500 Counts | Pain Relief | Body Aches | Headache | Arthritis | Cramps | Back Pain | Fever Reducer… (500 Count)

HealthA2Z

Free Shipping

Main Highlights

HealthA2Z Ibuprofen

HealthA2Z Ibuprofen

Benadryl Ultratabs Allergy Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Cold & Allergy Relief of Symptoms Like Sneezing, Runny Nose, Itchy Eyes & Throat, Hay Fever, 100 Count Tablets

Benadryl Ultratabs Allergy Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Cold & Allergy Relief of Symptoms Like Sneezing, Runny Nose, Itchy Eyes & Throat, Hay Fever, 100 Count Tablets

Benadryl

32% OffFree Shipping

Why we love it

Powerful relief in just one pill.
Effective against multiple allergens.
Safe for adults and children.

Main Highlights

Multi-Symptom Relief: Small coated Benadryl Ultratabs with 25 mg diphenhydramine HCl provide reliable relief from sneezing, runny nose, itchy throat, and itchy, watery eyes due to hay fever or the common cold
Portable Allergy Medicine: The convenient 100-count bottle fits in backpacks, purses, or desk drawers so you can keep effective allergy medicine with you. Small, easy-to-swallow oval tablets are ideal for on-the-go allergy control
Versatile Allergy & Cold Relief: Antihistamine tablets temporarily relieve symptoms from pollen, dust, mold, pet dander, and food-reaction hives; take one tablet every four to six hours, and do not exceed six doses in any 24-hour period as directed
Active Ingredient & Age Guidance: Each Benadryl Ultratab contains 25 mg diphenhydramine HCl to help ease upper respiratory allergy symptoms; suitable for adults and children ages six and up when used exactly as directed on the product packaging
Value Pack Supply: 100-count package of allergy relief tablets helps you stay prepared for seasonal peaks and year-round triggers; compact tablets are easy to carry so relief is available at home, work, or travel whenever symptoms strike

Benadryl Ultratabs Allergy Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Cold & Allergy Relief of Symptoms Like Sneezing, Runny Nose, Itchy Eyes & Throat, Hay Fever, 100 Count Tablets

32% OffFree Shipping

Why we love it

Powerful relief in just one pill.
Effective against multiple allergens.
Safe for adults and children.

Main Highlights

Multi-Symptom Relief: Small coated Benadryl Ultratabs with 25 mg diphenhydramine HCl provide reliable relief from sneezing, runny nose, itchy throat, and itchy, watery eyes due to hay fever or the common cold
Portable Allergy Medicine: The convenient 100-count bottle fits in backpacks, purses, or desk drawers so you can keep effective allergy medicine with you. Small, easy-to-swallow oval tablets are ideal for on-the-go allergy control
Versatile Allergy & Cold Relief: Antihistamine tablets temporarily relieve symptoms from pollen, dust, mold, pet dander, and food-reaction hives; take one tablet every four to six hours, and do not exceed six doses in any 24-hour period as directed
Active Ingredient & Age Guidance: Each Benadryl Ultratab contains 25 mg diphenhydramine HCl to help ease upper respiratory allergy symptoms; suitable for adults and children ages six and up when used exactly as directed on the product packaging
Value Pack Supply: 100-count package of allergy relief tablets helps you stay prepared for seasonal peaks and year-round triggers; compact tablets are easy to carry so relief is available at home, work, or travel whenever symptoms strike

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes for Fast Release, Gentle on Stomach, 500 mg Per Gelcap, 100 Count OTC Medicine

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes for Fast Release, Gentle on Stomach, 500 mg Per Gelcap, 100 Count OTC Medicine

Tylenol

25% OffFree Shipping

Why we love it

Fast relief from aches.
Gentle on the stomach.
Doctor recommended for pain.

Main Highlights

Fast-acting relief: Tylenol Extra Strength Rapid Release Gels feature 500 mg acetaminophen per gelcap to temporarily relieve minor aches and pains from headache, backache, arthritis, toothache, menstrual cramps, muscle aches, and fever; 100-count
Rapid-release technology: Laser-drilled holes in each gelcap release acetaminophen faster for extra strength pain relief; gelcaps are gentle on the stomach and suitable for adults and children 12 years and older
Multi-symptom support: Use as a fever reducer and to relieve headache, backache, muscle aches, arthritis pain, toothache, and joint discomfort; also helps with menstrual and premenstrual cramps and pain from the common cold or flu
Dosage instructions: Adults and children 12 years and older take two gelcaps every six hours while symptoms last; do not exceed six gelcaps in 24 hours; always follow the label directions for safe use of acetaminophen and dosing guidance
Doctor-recommended brand: Choose Tylenol, the #1 doctor-recommended brand for pain relief and fever reduction based on 2021 IQVIA survey; over-the-counter medication with 500 mg acetaminophen per gelcap that’s gentle on the stomach

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes for Fast Release, Gentle on Stomach, 500 mg Per Gelcap, 100 Count OTC Medicine

25% OffFree Shipping

Why we love it

Fast relief from aches.
Gentle on the stomach.
Doctor recommended for pain.

Main Highlights

Fast-acting relief: Tylenol Extra Strength Rapid Release Gels feature 500 mg acetaminophen per gelcap to temporarily relieve minor aches and pains from headache, backache, arthritis, toothache, menstrual cramps, muscle aches, and fever; 100-count
Rapid-release technology: Laser-drilled holes in each gelcap release acetaminophen faster for extra strength pain relief; gelcaps are gentle on the stomach and suitable for adults and children 12 years and older
Multi-symptom support: Use as a fever reducer and to relieve headache, backache, muscle aches, arthritis pain, toothache, and joint discomfort; also helps with menstrual and premenstrual cramps and pain from the common cold or flu
Dosage instructions: Adults and children 12 years and older take two gelcaps every six hours while symptoms last; do not exceed six gelcaps in 24 hours; always follow the label directions for safe use of acetaminophen and dosing guidance
Doctor-recommended brand: Choose Tylenol, the #1 doctor-recommended brand for pain relief and fever reduction based on 2021 IQVIA survey; over-the-counter medication with 500 mg acetaminophen per gelcap that’s gentle on the stomach

Gas-X Maximum Strength Gas Relief Softgels with Simethicone 250 mg - 30 Count

Gas-X Maximum Strength Gas Relief Softgels with Simethicone 250 mg - 30 Count

Gas-X

Free Shipping

Why we love it

Fast relief from gas discomfort.
Portable and easy to swallow.
Highest dose available over-the-counter.

Main Highlights

One 30 count package of Gas-X Maximum Strength Gas Relief Softgels with Simethicone 250 mg; number 1 Anti-Gas Relief Brand
Gas-X simethicone softgels provide fast gas and bloating relief
Gas-X antigas goes to work in minutes to provide bloating and gas relief, rescuing you from embarrassing situations and helping you get back to feeling like yourself
Contains 250 mg of simethicone—the highest dose available in any over-the-counter antigas pills
Simethicone 250 mg gas relief softgels are portable and easy to swallow
Gas-X is the number 1 doctor recommended OTC anti-gas product*
Adults and children 12 years of age and older may take one or two simethicone gas relief softgels as needed, not to exceed two softgels in 24 hours
Gas-X is the name you turn to when you need serious gas relief
HSA and FSA eligible product

Gas-X Maximum Strength Gas Relief Softgels with Simethicone 250 mg - 30 Count

Free Shipping

Why we love it

Fast relief from gas discomfort.
Portable and easy to swallow.
Highest dose available over-the-counter.

Main Highlights

One 30 count package of Gas-X Maximum Strength Gas Relief Softgels with Simethicone 250 mg; number 1 Anti-Gas Relief Brand
Gas-X simethicone softgels provide fast gas and bloating relief
Gas-X antigas goes to work in minutes to provide bloating and gas relief, rescuing you from embarrassing situations and helping you get back to feeling like yourself
Contains 250 mg of simethicone—the highest dose available in any over-the-counter antigas pills
Simethicone 250 mg gas relief softgels are portable and easy to swallow
Gas-X is the number 1 doctor recommended OTC anti-gas product*
Adults and children 12 years of age and older may take one or two simethicone gas relief softgels as needed, not to exceed two softgels in 24 hours
Gas-X is the name you turn to when you need serious gas relief
HSA and FSA eligible product