10 Best Preservative Free Eye Gel Drops For Dry Eyes Nighttime of 2025

Last updated on 07/16/2025
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1
9.9
Exceptional
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Systane Nighttime Lubricant Eye Ointment 3.50 g , 0.12 Oz (Pack of 3)
Systane
Systane Nighttime Lubricant Eye Ointment 3.50 g , 0.12 Oz (Pack of 3)
21% OffFree Shipping
Why We Love It
  • Trusted brand for eye care.
  • Cost-effective bulk purchasing option.
  • Provides long-lasting moisture relief.
Main Highlights
  • Brought to you by Systane
  • Buy in bulk & save!
9.9
Exceptional
Save 21%
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Best Value
2
9.9
Exceptional
Systane Nighttime Lubricant Eye Ointment 3.5g Tube - Pack of 2
Systane
Systane Nighttime Lubricant Eye Ointment 3.5g Tube - Pack of 2
Free Shipping
Why We Love It
  • Nighttime relief for dry eyes.
  • Soothes and protects irritation.
  • Forms long-lasting protective layer.
Main Highlights
  • Pack of 2
  • #1 Dr Recommended Brand of Artificial Tears*
  • Provides nighttime relief of dry eye symptoms
  • Ointment soothes and protects against dry, irritated eyes
  • Forms long-lasting, protective layer on eyes while you sleep
9.9
Exceptional
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3
9.7
Exceptional
TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)
TheraTears
TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)
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Why We Love It
  • Soothing overnight relief provided.
  • Natural electrolytes promote hydration.
  • Preservative-free for sensitive comfort.
Main Highlights
  • IMMEDIATE DRY EYE RELIEF: TheraTears Lubricating Liquid Gel Eye Drops provide immediate, long-lasting relief of dry eye symptoms
  • HYDRATING EYE DROPS: TheraTears Nighttime dry eye drops have 4X the lubrication* for a subtly thicker, extra hydrating experience for tired, dry eyes while you sleep; *vs. TheraTears Original
  • PRESERVATIVE FREE EYE DROPS: These eye drops for dry eyes are formulated with the 5 vital electrolytes found in natural tears and are individually sealed for preservative free eye drops in a single-use vial
  • CREATED BY AN OPHTHALMOLOGIST: TheraTears was created by an ophthalmologist after 18 years of research for a one-of-a-kind eye drop
  • DOCTOR RECOMMENDED: Doctor recommended and created to bring balance and hydration to dry eyes
9.7
Exceptional
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4
9.6
Superb
Save 35%
Refresh Celluvisc Lubricant Eye Gel Preservative-Free Tears, 0.01 fl oz (0.4 mL), 30 Single-Use Containers
Refresh
Refresh Celluvisc Lubricant Eye Gel Preservative-Free Tears, 0.01 fl oz (0.4 mL), 30 Single-Use Containers
35% OffFree Shipping
Why We Love It
  • Original strength formula works wonders.
  • Relieves dry eye discomfort quickly.
  • Trusted by doctors for decades.
Main Highlights
  • Original strength gel formula
  • Relieves dry, burning, irritated eyes
  • Alleviates discomfort
  • Keeps eyes feeling better longer
  • doctor recommended with over 30 years of experience. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey
9.6
Superb
Save 35%
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5
9.5
Superb
Save 20%
Refresh Optive Gel Drops Lubricant Eye Gel For Dry Eyes, 0.33 Oz Sterile
Refresh
Refresh Optive Gel Drops Lubricant Eye Gel For Dry Eyes, 0.33 Oz Sterile
20% OffFree Shipping
Why We Love It
  • Extended relief for eye dryness.
  • Comprehensive gel formula for comfort.
  • Hydrocell technology ensures lasting hydration.
Main Highlights
  • Extended relief plus protection for dry, irritated eyes
  • Our most comprehensive gel formula
  • Anytime relief, day or night
  • Feels like a drop but works like a gel for lasting comfort
  • Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
  • #1 doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
9.5
Superb
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6
9.4
Superb
Save 37%
OCuSOFT Retaine MGD Ophthalmic Emulsion - Complete Dry Eye Relief - Soothes Red & Irritated Eyes - 30 Count Preservative-Free Single-Use Containers - 0.01 Fl Oz
OCuSOFT
OCuSOFT Retaine MGD Ophthalmic Emulsion - Complete Dry Eye Relief - Soothes Red & Irritated Eyes - 30 Count Preservative-Free Single-Use Containers - 0.01 Fl Oz
37% OffFree Shipping
Why We Love It
  • Revolutionary preservative-free formula.
  • Long-lasting relief for dry eyes.
  • Advanced cationic oil technology.
Main Highlights
  • Retained mgd is a revolutionary preservative-free ophthalmic emulsion that moisturizes, lubricates and protects moderate to severe dry eyes
  • Provides long-lasting relief utilizing nova orb,
  • Proprietary cationic oil emulsion technology that effectively delivers ingredients through electrostatic attraction between positively charged droplets and the negatively charged ocular surface
  • Retained MGD is a revolutionary preservative-free ophthalmic emulsion that moisturizes, lubricates and protects moderate to severe dry eyes.
  • The hypo tonicity of the emulsion adds moisture by lowering the salt concentration of tears while the lipid component lubricates and protects the surface of the eye.
  • Retained MGD is a revolutionary preservative-free ophthalmic emulsion that moisturizes, lubricates and protects moderate to severe dry eyes.
  • Provides long-lasting relief utilizing Nova orb,
  • proprietary cationic oil emulsion technology that effectively delivers ingredients through electrostatic attraction between positively charged droplets and the negatively charged ocular surface.
  • The hypo tonicity of the emulsion adds moisture by lowering the salt concentration of tears while the lipid component lubricates and protects the surface of the eye.
9.4
Superb
Save 37%
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7
9.4
Superb
Save 16%
Optase HYLO Night Eye Ointment - Preservative Free Lubricant & Nighttime Eye Ointment for Blepharitis and Stye - .18 oz
Optase
Optase HYLO Night Eye Ointment - Preservative Free Lubricant & Nighttime Eye Ointment for Blepharitis and Stye - .18 oz
16% OffFree Shipping
Why We Love It
  • Preservative free formula.
  • Long lasting overnight relief.
  • Gentle on sensitive skin.
Main Highlights
  • PRESERVATIVE FREE NIGHTTIME DRY EYE RELIEF: OPTASE HYLO Night Ointment offers soothing and comfortable lubrication to help resolve symptoms associated with Blepharitis, Dry Eye, and other eye problems
  • LONG LASTING OVERNIGHT PROTECTION: The well tolerated formula of OPTASE HYLO Night provides over 6 hours of physical retention for nighttime dry eye relief, without crusty, impaired morning vision
  • SAFE FOR EVERYDAY USE, 6 MONTH STABILITY: OPTASE HYLO Night Dry Eye Ointment is safe for continuous night time use. Simply apply once onto the eyelids before bed for overnight ocular lubrication
  • BALANCED FOR COMFORT: OPTASE HYLO Night is gentle and comfortable on the sensitive skin around the lids and lashes, without the irritation or gritty sensation found in other nighttime ointments
  • SUITABLE FOR ALL AGES: The preservative free, phosphate free protection of OPTASE HYLO Night Dry Eye Ointment is safe for children and adults, providing effective dry eye symptom relief for all ages
  • USE AS DIRECTED: The active ingredients White Petrolatum, Lanolin, and Light Mineral Oil relieves and protects from dry eye symptoms. Always read the label, warnings, and instructions for use
9.4
Superb
Save 16%
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8
9.3
Superb
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Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)
Systane
Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)
40% OffFree Shipping
Why We Love It
  • Rapid relief for sensitive eyes.
  • Safe and preservative-free formula.
  • Advanced nano droplets enhance coverage.
Main Highlights
  • Fast acting hydration for sensitive eyes
  • Preservative free tear evaporation protection
  • Nano droplets for better coverage
9.3
Superb
Save 40%
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9
9.1
Superb
Save 20%
iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary
iVIZIA
iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary
20% OffFree Shipping
Why We Love It
  • Thicker formula for overnight relief.
  • Hydrating polymers protect and moisturize.
  • Preservative-free for sensitive eyes.
Main Highlights
  • Your Dry Eyes Deserve Better: Thicker formula for overnight use, our gel provides more lubrication and moisture than our daytime formula and is ideal to relieve severe dry eye symptoms.
  • Free of Irritating Preservatives: Sterile, preservative-free, and can be used before or after eye surgery.
  • Sterile Single-Use Vials: iVIZIA Lubricant Eye Gel is offered in preservative-free sterile, single-use vials that are convenient and easy to use for severe dry eye or nighttime use.
  • iVIZIA – We See a Better Way: for healthy, comfortable eyelids
9.1
Superb
Save 20%
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10
8.9
Excellent
Save 7%
Systane Nighttime Lubricant Eye Ointment 3.5g Tube
Systane
Systane Nighttime Lubricant Eye Ointment 3.5g Tube
7% OffFree Shipping
Why We Love It
  • Doctor recommended for efficacy.
  • Nighttime relief for dry eyes.
  • Protective, preservative-free formula.
Main Highlights
  • #1 Dr Recommended Brand of Artificial Tears*
  • Provides nighttime relief of dry eye symptoms
  • Ointment soothes and protects against dry, irritated eyes
  • Forms long-lasting, protective layer on eyes while you sleep
  • Safe, preservative-free formula
8.9
Excellent
Save 7%
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