10 Best Preservative Free Eye Gel Drops For Dry Eyes Nighttime of 2025
Last updated on 09/15/2025
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Best Choice
1
Systane Nighttime Lubricant Eye Ointment 3.50 g , 0.12 Oz (Pack of 3)
Systane
21% OffFree Shipping
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Systane
Systane Nighttime Lubricant Eye Ointment 3.50 g , 0.12 Oz (Pack of 3)
21% OffFree Shipping
Why we love it
- Trusted brand for eye care.
- Cost-effective bulk purchasing option.
- Provides long-lasting moisture relief.
Main Highlights
- Brought to you by Systane
- Buy in bulk & save!
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Value for Money
2
TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)
TheraTears
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TheraTears
TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)
Free Shipping
Why we love it
- Soothing overnight relief provided.
- Natural electrolytes promote hydration.
- Preservative-free for sensitive comfort.
Main Highlights
- Dry eye relief without preservatives: TheraTears nighttime lubricating eye drops in single-use vials provide soothing overnight relief from dry eye symptoms which may be better for people with sensitive eyes, with 4x the active lubricating ingredient of TheraTears original, no preservatives for sensitive eyes
- Instant hydration: TheraTears eye drops restore eyes’ natural balance and deliver hydration relief for dry eyes, because hydration is essential for eye health
- Electrolytes: TheraTears eye drops’ unique formula contains OxyLytes, the 5 vital electrolytes found in natural tears
- Created by an ophthalmologist: The TheraTears formula was created by an ophthalmologist, following 18 years of research, for a one-of-a-kind eye drop
- Doctor-recommended: TheraTears is a doctor-recommended brand (per ProVoice Survey data collected 9/1/23-8/31/24), created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details
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3
Systane PRO PF Multi-dose Preservative-Free Lubricant Eye Drops 2 Count
Systane
21% OffFree Shipping
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Systane
Systane PRO PF Multi-dose Preservative-Free Lubricant Eye Drops 2 Count
21% OffFree Shipping
Why we love it
- Triple-action relief for dry eyes.
- Hydrating formula supports long-lasting moisture.
- Gentle and preservative-free for sensitivity.
Main Highlights
- Triple-Action Dry Eye Relief: Systane Pro Preservative Free Eye Drops hydrate, restore and protect dry eyes for long-lasting relief
- Long-Lasting Hydration: Systane Pro Preservative Free lubricating eye drops are formulated with Hyaluronate, a moisturizer that occurs naturally in tears, to support extended hydrationfor all types of dry eye relief
- Tear Evaporation Protection: This unique formula enhanced with lipid nanodroplets helps lock in moisture and reduce tear evaporation
- Preservative-Free Formula: The gentle, preservative-free formula is ideal for sensitive eyes
- Trusted Brand: Systane is a trusted name in eye care, recommended by eye care professionals for its effective and reliable relief from dry eyes
- Convenient Size: The 10mL oz bottle is perfect for daily use, offering you triple action dry eye relief at your fingertips
- Contact Lens Friendly: safe for use with soft contact lenses
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4
Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers
Refresh
32% OffFree Shipping
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Refresh
Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers
32% OffFree Shipping
Why we love it
- Fast relief for dry eyes.
- Lasting comfort and protection.
- Convenient single-use vials available.
Main Highlights
- FAST-ACTING: Rapid relief to comfort dry, irritated eyes
- LASTING RELIEF: Soothes and prevents further irritation
- TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
- PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
- ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
- ON-THE-GO VIALS: 60 sterile single-use vials per carton that are easy and safe to use as often as needed
- TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
- FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan
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5
Systane Nighttime Lubricant Eye Ointment 3.50 g (2 Pack) Lubricates and Comforts Dry Eyes Preservative-Free Rich Ointment for Nighttime Relief
Systane
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Systane
Systane Nighttime Lubricant Eye Ointment 3.50 g (2 Pack) Lubricates and Comforts Dry Eyes Preservative-Free Rich Ointment for Nighttime Relief
Free Shipping
Why we love it
- Restores comfort while sleeping.
- Long-lasting dry eye relief.
- Safe, preservative-free formula.
Main Highlights
- LUBRICANT OINTMENT: Help restore comfort and relieve dry eye while you sleep
- FEATURES: Sterile gel drops deliver long-lasting relief of dry-eye symptoms with easy overnight use
- EYE RELIEF: Long-lasting nighttime protection
- FORMULATION: Unique combination of ingredients can help provide relief of symptoms brought on by windy conditions, sunny weather, and digital eye strain
- DRY EYE THERAPY: Safe; Preservative-free formula
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6
Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)
Systane
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Systane
Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)
Free Shipping
Why we love it
- Rapid relief for sensitive eyes.
- Safe and preservative-free formula.
- Advanced nano droplets enhance coverage.
Main Highlights
- Fast acting hydration for sensitive eyes
- Preservative free tear evaporation protection
- Nano droplets for better coverage
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7
iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary
iVIZIA
8% OffFree Shipping
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iVIZIA
iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary
8% OffFree Shipping
Why we love it
- Thicker formula for overnight relief.
- Hydrating polymers protect and moisturize.
- Preservative-free for sensitive eyes.
Main Highlights
- Your Dry Eyes Deserve Better: Thicker formula for overnight use, our gel provides more lubrication and moisture than our daytime formula and is ideal to relieve severe dry eye symptoms.
- Free of Irritating Preservatives: Sterile, preservative-free, and can be used before or after eye surgery.
- Sterile Single-Use Vials: iVIZIA Lubricant Eye Gel is offered in preservative-free sterile, single-use vials that are convenient and easy to use for severe dry eye or nighttime use.
- IVIZIA – We See a Better Way: for healthy, comfortable eyelids
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8
Refresh Celluvisc Lubricant Eye Gel For Dry Eyes, Preservative-Free Drops, 0.01 Fl Oz Single-Use Containers, 30 Count
Refresh
32% OffFree Shipping
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Refresh
Refresh Celluvisc Lubricant Eye Gel For Dry Eyes, Preservative-Free Drops, 0.01 Fl Oz Single-Use Containers, 30 Count
32% OffFree Shipping
Why we love it
- Original strength formula works wonders.
- Relieves dry eye discomfort quickly.
- Trusted by doctors for decades.
Main Highlights
- Original strength gel formula
- Relieves dry, burning, irritated eyes
- Alleviates discomfort
- Keeps eyes feeling better longer
- #1 doctor recommended with over 30 years of experience.* *REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey
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9
Refresh Optive Gel Drops Lubricant Eye Gel For Dry Eyes, 0.33 Oz Sterile
Refresh
20% OffFree Shipping
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Refresh
Refresh Optive Gel Drops Lubricant Eye Gel For Dry Eyes, 0.33 Oz Sterile
20% OffFree Shipping
Why we love it
- Extended relief for eye dryness.
- Comprehensive gel formula for comfort.
- Hydrocell technology ensures lasting hydration.
Main Highlights
- Extended relief plus protection for dry, irritated eyes
- Our most comprehensive gel formula
- Anytime relief, day or night
- Feels like a drop but works like a gel for lasting comfort
- Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
- #1 doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
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10
TheraTears Liquid Gel Nighttime Lubricating Eye Drops for Dry Eyes, Single-Use Vials, 30 Count
TheraTears
26% OffFree Shipping
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TheraTears
TheraTears Liquid Gel Nighttime Lubricating Eye Drops for Dry Eyes, Single-Use Vials, 30 Count
26% OffFree Shipping
Why we love it
- Soothing overnight dry eye relief.
- Silky hydration for your eyes.
- Doctor recommended for sensitive eyes.
Main Highlights
- Dry eye relief without preservatives: TheraTears nighttime lubricating eye drops in single-use vials provide soothing overnight relief from dry eye symptoms, 4x the active lubricating ingredient of TheraTears original, no preservatives for sensitive eyes
- Instant hydration: TheraTears eye drops restore eyes’ natural balance and deliver hydration relief for dry eyes, because hydration is essential for eye health
- Electrolytes: TheraTears eye drops’ unique formula contains OxyLytes, the 5 vital electrolytes found in natural tears
- Created by an ophthalmologist: The TheraTears formula was created by an ophthalmologist, following 18 years of research, for a one-of-a-kind eye drop
- Doctor-recommended: TheraTears is a doctor-recommended brand (per ProVoice Survey data collected 9/1/23-8/31/24), created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details
Show More