10 Best Preservative Free Eye Drops For Severe Dry Eyes of 2025

Last updated on 08/06/2025

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Rain Preservative Free Eye Drops for Severe Dry Eyes – More Natural Eye Drops for Dry Eye Relief – Proprietary Formula Relieves Dry, Itchy Eyes – Take Back Your Eye Comfort

Rain Preservative Free Eye Drops for Severe Dry Eyes – More Natural Eye Drops for Dry Eye Relief – Proprietary Formula Relieves Dry, Itchy Eyes – Take Back Your Eye Comfort

Targeted relief for dry eyes.
Contact lens compatible formula.
Preservative-free for sensitive eyes.

Main Highlights

Targeted Relief for Dry Eyes: Specially formulated for moderate to severe dry eye conditions, Rain eye drops provide effective, long-lasting relief, ensuring your eyes feel comfortable and refreshed.
Contact Lens Compatible: Our unique, moisturizing drops are designed to be contact lens friendly, offering soothing hydration without affecting your lenses, making them perfect for daily use.
Preservative-Free for Sensitive Eyes: Free from preservatives and harsh chemicals, Rain lubricating drops are ideal for those with sensitive eyes, reducing the risk of irritation and providing gentle, natural relief.
Artificial Tears for Natural Comfort: Mimicking the natural hydration of tears, these artificial tears offer immediate and lasting comfort, alleviating symptoms of dryness and irritation in your eyes.
CMS Eye Moisture: Experience extended relief from eye discomfort with our specially formulated eye drops. Infused with CMS Eye Moisture technology, Rain keeps your eyes hydrated longer, maintaining moisture and protecting against dryness.

Optase Dry Eye Intense Drops - Preservative Free Eye Drops for Long Lasting Relief - Artificial Tears to Relieve Severe Dry Eye Symptoms - Multidose Bottle - Step 3 Hydrate - .33 fl oz, 300 Doses

Optase Dry Eye Intense Drops - Preservative Free Eye Drops for Long Lasting Relief - Artificial Tears to Relieve Severe Dry Eye Symptoms - Multidose Bottle - Step 3 Hydrate - .33 fl oz, 300 Doses

Moisturizes and protects your eyes.
Preservative free for added safety.
Convenient multi-use bottle design.

Main Highlights

MOISTURIZE AND PROTECT: Made of glycerin and quality ingredients, Optase Dry Eye Intense Drops mix with the natural oils needed to protect your tears and hydrate your eyes to improve tear quality
PRESERVATIVE FREE: Optase Intense Eye Drops is the only product of its kind to provide a preservative free combination of ingredients designed to treat dry eye patients in a unique multi-dose bottle
MODERATE TO SEVERE DRY EYE RELIEF: The long lasting formulation of Optase Intense provides comfort for dry eye and post operative patients. And it is contact lens safe, providing relief when needed
ADVANCED BOTTLE TECHNOLOGY: A convenient multi-use drop bottle with advanced technology maintains sterility over 3 months without preservatives. Avoid the hassle of individual vials while on the go
COMPLETE DOCTOR RECOMMENDED EYE CARE RELIEF: OPTASE is the expert recommended 3-step regimen to help tackle the cause and symptoms of Dry Eyes, Blepharitis and Meibomian Gland Dysfunction (MGD)

Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)

Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)

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Rapid relief for sensitive eyes.
Safe and preservative-free formula.
Advanced nano droplets enhance coverage.

Main Highlights

Fast acting hydration for sensitive eyes
Preservative free tear evaporation protection
Nano droplets for better coverage

Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)

Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)

Fast hydration for dry eyes.
Preservative free for sensitive users.
Compatible with all contact lenses.

Main Highlights

Hydrates fast and provides long-lasting relief for dry eyes
Preservative free eye drops
Contains hyaluronate for advanced hydration
Safe for use with all contact lenses
Extra moisturizing eye drops for sensitive eyes

Biotrue Hydration Boost, Preservative-Free Eye Drops for Dry Eyes, Instantly Moisturizes, Rehydrates, Contact Lens Friendly, Refresh & Relieve Eye Irritation, 0.33 FL Oz (Pack of 2)

Biotrue Hydration Boost, Preservative-Free Eye Drops for Dry Eyes, Instantly Moisturizes, Rehydrates, Contact Lens Friendly, Refresh & Relieve Eye Irritation, 0.33 FL Oz (Pack of 2)

Naturally inspired ingredients enhance comfort.
Provides instant moisture relief.
Preservative-free for gentle use.

Main Highlights

NATURALLY INSPIRED INGREDIENTS: Biotrue Hydration Boost Eye Drops are enhanced with HA (Hyaluronan), Antioxidant, and Electrolyte and provide instant moisture for dry eyes.
INSTANT MOISTURE: For dry, irritated eyes due to screen and environmental stressors.
Special preservative free, multi-dose bottle.
BIOTRUE EYE DROPS: Not only are the Hydration Boost Eye Drops free of preservatives but they are also pH balanced for comfort.
EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solutions to eye drops, vitamins, & ointments to help your eyes feel moisturized and protected.

OPTASE MGD Advanced Dry Eye Drops - Preservative Free Drops for Dry Eyes and MGD - Lipid-Based Artificial Tears - Demet Technology, Multidose Bottle, Contact Lens Safe - .33 fl oz, 300 Doses

OPTASE MGD Advanced Dry Eye Drops - Preservative Free Drops for Dry Eyes and MGD - Lipid-Based Artificial Tears - Demet Technology, Multidose Bottle, Contact Lens Safe - .33 fl oz, 300 Doses

Innovative technology for clear relief.
Natural lipid for maximum comfort.
Convenient, preservative-free multi-use bottle.

Main Highlights

INNOVATIVE DEMET TECHNOLOGY: OPTASE MGD Advanced Eye Drops offers a superior lubricating eye drops in an optically clear, non-blurry formula for relief from moderate to severe symptoms of MGD
LIPID BASED DRY EYE RELIEF: The advanced formulation of OPTASE MGD eye drops utilizes Sacha Inchi seed oil, a high quality, natural lipid with a balanced Omega 3 and Omega 6 ratio for maximum comfort
EFFECTIVELY MANAGE MGD SYMPTOMS: With an innovative lipid solution, OPTASE MGD strengthens, protects, and hydrates the tear film to help soothe symptoms of MGD and evaporative lipid deficiency
ADVANCED BOTTLE TECHNOLOGY: The multi-use bottle of OPTASE MGD Advanced offers 300 drops, maintains sterility over 3 months, and is preservative free and contact lens safe for convenience on the go
COMPLETE DOCTOR RECOMMENDED EYE CARE RELIEF: OPTASE is the expert recommended 3-step regimen to help tackle the cause and symptoms of Dry Eyes, especially Meibomian Gland Dysfunction (MGD)
USE AS DIRECTED: Please note this product includes both a manufactured date and an expiration date. Always read the label, warnings, and instructions for use

Systane Ultra Lubricant Eye Drops, 60 Count (Pack of 1), (Packaging may vary)

Systane Ultra Lubricant Eye Drops, 60 Count (Pack of 1), (Packaging may vary)

Doctor Recommended for Trust.
Extended Protection for Comfort.
Quick Relief for Dry Eyes.

Main Highlights

#1 Dr Recommended Brand of Artificial Tears*
Extended Protection
Fast Long-Lasting Dry Eye Symptom Relief
Reduces both the signs and symptoms of dry eye
Single-Use Convenience. Store at room temperature

Systane PRO PF Multi-dose Preservative-Free Lubricant Eye Drops 2 Count

Systane PRO PF Multi-dose Preservative-Free Lubricant Eye Drops 2 Count

Triple-action relief for dry eyes.
Hydrating formula supports long-lasting moisture.
Gentle and preservative-free for sensitivity.

Main Highlights

Triple-Action Dry Eye Relief: Systane Pro Preservative Free Eye Drops hydrate, restore and protect dry eyes for long-lasting relief
Long-Lasting Hydration: Systane Pro Preservative Free lubricating eye drops are formulated with Hyaluronate, a moisturizer that occurs naturally in tears, to support extended hydrationfor all types of dry eye relief
Tear Evaporation Protection: This unique formula enhanced with lipid nanodroplets helps lock in moisture and reduce tear evaporation
Preservative-Free Formula: The gentle, preservative-free formula is ideal for sensitive eyes
Trusted Brand: Systane is a trusted name in eye care, recommended by eye care professionals for its effective and reliable relief from dry eyes
Convenient Size: The 10mL oz bottle is perfect for daily use, offering you triple action dry eye relief at your fingertips
Contact Lens Friendly^: safe for use with soft contact lenses

Systane Ultra Multi-Dose Preservative-Free Eye Drops Twin Pack (2x10ml)

Systane Ultra Multi-Dose Preservative-Free Eye Drops Twin Pack (2x10ml)

Fast-Acting Hydration for Relief.
Sensitive Eyes Receive Gentle Care.
Protection Against Tear Evaporation.

Main Highlights

Preservative-Free Lubricant Eye Drops
Fast-Acting Hydration and lasting dry eye relief
Moisture rich formula eye drops for sensitive eyes
Tear evaporation protection for high-performance dry eye symptom relief that lasts

OCuSOFT Retaine MGD Ophthalmic Emulsion - Complete Dry Eye Relief - Soothes Red & Irritated Eyes - 30 Count Preservative-Free Single-Use Containers - 0.01 Fl Oz

OCuSOFT Retaine MGD Ophthalmic Emulsion - Complete Dry Eye Relief - Soothes Red & Irritated Eyes - 30 Count Preservative-Free Single-Use Containers - 0.01 Fl Oz

37% OffFree Shipping

Revolutionary preservative-free formula.
Long-lasting relief for dry eyes.
Advanced cationic oil technology.

Main Highlights

Retained mgd is a revolutionary preservative-free ophthalmic emulsion that moisturizes, lubricates and protects moderate to severe dry eyes
Provides long-lasting relief utilizing nova orb,
Proprietary cationic oil emulsion technology that effectively delivers ingredients through electrostatic attraction between positively charged droplets and the negatively charged ocular surface
Retained MGD is a revolutionary preservative-free ophthalmic emulsion that moisturizes, lubricates and protects moderate to severe dry eyes.
The hypo tonicity of the emulsion adds moisture by lowering the salt concentration of tears while the lipid component lubricates and protects the surface of the eye.
Retained MGD is a revolutionary preservative-free ophthalmic emulsion that moisturizes, lubricates and protects moderate to severe dry eyes.
Provides long-lasting relief utilizing Nova orb,
proprietary cationic oil emulsion technology that effectively delivers ingredients through electrostatic attraction between positively charged droplets and the negatively charged ocular surface.
The hypo tonicity of the emulsion adds moisture by lowering the salt concentration of tears while the lipid component lubricates and protects the surface of the eye.