10 Best Nighttime Gel Eye Drops of 2025
Last updated on 09/07/2025
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Best Choice
1
GenTeal Tears Lubricant Eye Ointment, Night-Time Ointment, 0.12 Fl Oz (Pack of 3)
Genteal
6% Off
Genteal
GenTeal Tears Lubricant Eye Ointment, Night-Time Ointment, 0.12 Fl Oz (Pack of 3)
6% Off
Why We Love It
- Provides effective dry eye relief.
- Long-lasting comfort through the night.
- Safe and preservative-free formula.
Main Highlights
- Night-time dry eye relief
- Concentrated ointment formula
- Long lasting night-time comfort
- Preservative & lanolin free
Value for Money
2
TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)
TheraTears
Free Shipping
TheraTears
TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)
Free Shipping
Why We Love It
- Soothing overnight relief provided.
- Natural electrolytes promote hydration.
- Preservative-free for sensitive comfort.
Main Highlights
- Dry eye relief without preservatives: TheraTears nighttime lubricating eye drops in single-use vials provide soothing overnight relief from dry eye symptoms which may be better for people with sensitive eyes, with 4x the active lubricating ingredient of TheraTears original, no preservatives for sensitive eyes
- Instant hydration: TheraTears eye drops restore eyes’ natural balance and deliver hydration relief for dry eyes, because hydration is essential for eye health
- Electrolytes: TheraTears eye drops’ unique formula contains OxyLytes, the 5 vital electrolytes found in natural tears
- Created by an ophthalmologist: The TheraTears formula was created by an ophthalmologist, following 18 years of research, for a one-of-a-kind eye drop
- Doctor-recommended: TheraTears is a doctor-recommended brand (per ProVoice Survey data collected 9/1/23-8/31/24), created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details
3
Systane Lubricant Eye Gel Drops 10 ml, 2 Count
Systane
Free Shipping
Systane
Systane Lubricant Eye Gel Drops 10 ml, 2 Count
Free Shipping
Why We Love It
- Convenient drop for easy use.
- Gel-like protection for lasting safety.
- Dual pack ensures anytime readiness.
Main Highlights
- Convenience of a drop, protection of a gel
- Pack of 2
- Anytime protection
4
Refresh Liquigel Lubricant Eye Gel, 2 Bottles 0.5 Fl Oz (15mL) Each Sterile (30mL)
Refresh
Free Shipping
Refresh
Refresh Liquigel Lubricant Eye Gel, 2 Bottles 0.5 Fl Oz (15mL) Each Sterile (30mL)
Free Shipping
Why We Love It
- Long-lasting dry eye relief.
- Soothing gel for comfort.
- Safe for contact lens users.
Main Highlights
- Long-lasting relief for dry eyes day or night
- Soothing gel formula
- Safe to use with contact lenses
- No shaking required prior to use, unlike Systane Gel Drops
- Value size - two convenient multi-dose bottle
- Safe to use as often as needed
- Inventiv Health Research and Insights Treatment Answers, MAT ending October 2016
5
Systane Nighttime Lubricant Eye Ointment 3.50 g (2 Pack) Lubricates and Comforts Dry Eyes Preservative-Free Rich Ointment for Nighttime Relief
Systane
Free Shipping
Systane
Systane Nighttime Lubricant Eye Ointment 3.50 g (2 Pack) Lubricates and Comforts Dry Eyes Preservative-Free Rich Ointment for Nighttime Relief
Free Shipping
Why We Love It
- Restores comfort while sleeping.
- Long-lasting dry eye relief.
- Safe, preservative-free formula.
Main Highlights
- LUBRICANT OINTMENT: Help restore comfort and relieve dry eye while you sleep
- FEATURES: Sterile gel drops deliver long-lasting relief of dry-eye symptoms with easy overnight use
- EYE RELIEF: Long-lasting nighttime protection
- FORMULATION: Unique combination of ingredients can help provide relief of symptoms brought on by windy conditions, sunny weather, and digital eye strain
- DRY EYE THERAPY: Safe; Preservative-free formula
6
Systane Lub Eye Nightime Ointment 3.5g (6 Pack) 0.12 Ounce(Packaging May Vary)
Systane
20% Off
Systane
Systane Lub Eye Nightime Ointment 3.5g (6 Pack) 0.12 Ounce(Packaging May Vary)
20% Off
Why We Love It
- Gentle on the skin.
- Highly moisturizing formula.
- Compact and travel-friendly packaging.
Main Highlights
- Item Package Length: 8.001cm
- Item Package Width: 10.210cm
- Item Package Height: 13.208cm
- Ingredients: Active Ingredients: Mineral Oil (3%). White Petrolatum (94%). Inactive Ingredients: Anhydrous Liquid Lanolin (3%).
7
iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary
iVIZIA
8% OffFree Shipping
iVIZIA
iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary
8% OffFree Shipping
Why We Love It
- Thicker formula for overnight relief.
- Hydrating polymers protect and moisturize.
- Preservative-free for sensitive eyes.
Main Highlights
- Your Dry Eyes Deserve Better: Thicker formula for overnight use, our gel provides more lubrication and moisture than our daytime formula and is ideal to relieve severe dry eye symptoms.
- Free of Irritating Preservatives: Sterile, preservative-free, and can be used before or after eye surgery.
- Sterile Single-Use Vials: iVIZIA Lubricant Eye Gel is offered in preservative-free sterile, single-use vials that are convenient and easy to use for severe dry eye or nighttime use.
- IVIZIA – We See a Better Way: for healthy, comfortable eyelids
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Refresh Optive Gel Drops Lubricant Eye Gel For Dry Eyes, 0.33 Oz Sterile
Refresh
20% OffFree Shipping
Refresh
Refresh Optive Gel Drops Lubricant Eye Gel For Dry Eyes, 0.33 Oz Sterile
20% OffFree Shipping
Why We Love It
- Extended relief for eye dryness.
- Comprehensive gel formula for comfort.
- Hydrocell technology ensures lasting hydration.
Main Highlights
- Extended relief plus protection for dry, irritated eyes
- Our most comprehensive gel formula
- Anytime relief, day or night
- Feels like a drop but works like a gel for lasting comfort
- Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
- #1 doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
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Refresh Celluvisc Lubricant Eye Gel For Dry Eyes, Preservative-Free Drops, 0.01 Fl Oz Single-Use Containers, 30 Count
Refresh
31% OffFree Shipping
Refresh
Refresh Celluvisc Lubricant Eye Gel For Dry Eyes, Preservative-Free Drops, 0.01 Fl Oz Single-Use Containers, 30 Count
31% OffFree Shipping
Why We Love It
- Original strength formula works wonders.
- Relieves dry eye discomfort quickly.
- Trusted by doctors for decades.
Main Highlights
- Original strength gel formula
- Relieves dry, burning, irritated eyes
- Alleviates discomfort
- Keeps eyes feeling better longer
- #1 doctor recommended with over 30 years of experience.* *REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey
10
Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers
Refresh
46% OffFree Shipping
Refresh
Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers
46% OffFree Shipping
Why We Love It
- Fast relief for dry eyes.
- Lasting comfort and protection.
- Convenient single-use vials available.
Main Highlights
- FAST-ACTING: Rapid relief to comfort dry, irritated eyes
- LASTING RELIEF: Soothes and prevents further irritation
- TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
- PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
- ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
- ON-THE-GO VIALS: 60 sterile single-use vials per carton that are easy and safe to use as often as needed
- TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
- FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan