10 Best Nattokinase Supplement of 2025

Last updated on 08/20/2025

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Designs for Health Nattokinase with Serrapeptidase - Natto-Serrazime + Proteolytic Enzymes - Designed to Support a Healthy Circulatory System + Immune Health - Non-GMO Supplement (120 Capsules)

Designs for Health

Designs for Health Nattokinase with Serrapeptidase - Natto-Serrazime + Proteolytic Enzymes - Designed to Support a Healthy Circulatory System + Immune Health - Non-GMO Supplement (120 Capsules)

Supports healthy joint function.
Promotes normal inflammatory response.
Vegetarian-friendly and non-GMO.

Main Highlights

This formula is designed to support the body’s ability to breakdown and remove damaged cellular debris, tissue, and specific protein structures that are produced during the natural inflammatory process in response to trauma or injury.*
These proteolytic enzymes may help maintain healthy joints, support healthy circulatory, respiratory, and immune function, and promote a normal inflammatory response.*
Natto-Serrazime is a blend of two health-promoting proteolytic enzymes, Nattozimes and Serrazimes, derived from the fungi Aspergillus oryzae and Aspergillus melleus.
Vegetarian & Non-GMO - This product is Vegetarian-Friendly. Made without GMOs or Dairy.*
Clinically-Trusted Care - DFH is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals.**

Luma Nutrition Nattokinase Supplement - Japanese Natto 4000 FU Per Serving, Premium Heart Health Support - Vegan & Gluten Free - 60 Capsules - Made in USA

Luma Nutrition Nattokinase Supplement - Japanese Natto 4000 FU Per Serving, Premium Heart Health Support - Vegan & Gluten Free - 60 Capsules - Made in USA

Powerful Nattokinase dosage ensures effectiveness.
Supports vegan and gluten-free diets.
Made in USA for quality assurance.

Main Highlights

Premium Natto Extract: Luma Nutrition's powerful nattokinase supplement boasts superior quality and a powerful dosage of Nattokinase 4000 fu, twice as strong as other nattokinase 2000 fu products. These effective Nattokinase powder capsules promote healthy blood flow and circulation, supporting cardiovascular function and overall heart health.
Natural Heart Support: Nattokinase is an enzyme extracted from natto, a traditional Japanese fermented soybean dish. It's renowned for its fibrinolytic properties, meaning it helps break down fibrin, a protein involved in restricted blood flow. Without the presence of Serrapeptase or Lumbrokinase, this supplement works for vegan or gluten-free diets.
30 Day Supply: Each bottle of Luma's nattokinase supplement organic lasts for a month to maintain optimal freshness and provides natural heart health support. This nattokinase supplement for men and women makes the perfect monthly subscription.
3rd Party Tested: All of our products are 3rd party tested for purity and quality. Our Nattokinase is made in the USA in our fully certified facility. Non-gmo and the highest quality.
Proudly USA: All Luma Nutrition supplements are manufactured in GMP certified facilities in the United States to ensure product safety and quality is always upheld. Certificed by NSF December 2023. We are veteran owned and operated.

Arthur Andrew Medical, Nattovena, Pure Nattokinase Supplement, Double Strength 4,000 FUs per Capsule, 180

Arthur Andrew Medical

Arthur Andrew Medical, Nattovena, Pure Nattokinase Supplement, Double Strength 4,000 FUs per Capsule, 180

High potency for optimal health.
Promotes effective blood cleansing.
Supports overall well-being naturally.

Main Highlights

High potency: Contains pure Nattokinase—a fibrin-dissolving enzyme derived from a microbial (probiotic) fermentation process; Each capsule provides 4,000 fibrinolytic units (FUs), double the strength of standard nattokinase products
Fibrin cleanse: Formulated to cleanse your blood of fibrin and maintain optimal blood viscosity, supporting healthy blood flow*
Beyond heart health: Restores declining enzymes due to aging and eases symptoms such as fatigue and painful joints caused by unhealthy levels of fibrin in the blood*
Two to four capsules daily: Take with water and on an empty stomach; Vegan, non-GMO, kosher, GRAS certified
Innovation and science: Unlock your health's true potential with our therapeutic-grade enzyme and probiotic products, thoroughly tested for superior quality and purity

Zenavea - Nattokinase Supplement - 2000 FU of Enzyme - 270 Capsules of Nattokinase 100mg - Gluten Free, Non-GMO, Vegan

Zenavea - Nattokinase Supplement - 2000 FU of Enzyme - 270 Capsules of Nattokinase 100mg - Gluten Free, Non-GMO, Vegan

Powerful natural enzyme support.
Made in the USA quality.
Vegan, clean, and optimized formula.

Main Highlights

Unleash the Power of Natto: This vegan supplement harnesses the power of Nattokinase, a natural enzyme derived from the Japanese superfood, fermented soybeans. Supports healthy circulation and leg vessel function, promoting clot prevention.
Made in the USA - Potent 2000 FU Dose: Each Zenavea capsule packs a powerful 2,000 FU (fibrinolytic units) of Nattokinase, the recommended daily dosage. Manufactured in the USA under strict quality control for your peace of mind. Our 270-capsule bottle provides a convenient 9-month supply.
Enhance Blood Flow & Heart Health: Zenavea Nattokinase is known to support blood flow and circulation. This may contribute to overall health and heart health.
Clean, Optimized, & Trusted Formula: Our vegan capsules are FREE from GMOs, eggs, milk, fish, sugar, wheat, and gluten. We adhere to GMP standards, ensuring quality and purity.
Zenavea - Your Supplement Partner: Zenavea is a brand dedicated to providing high-quality nutritional supplements. Our sugar-free, gluten-free Nattokinase capsules offer a convenient and effective way to support your well-being.

NatureBell Nattokinase Supplement 8,000 FU Per Serving, 240 Veggie Capsules | Traditional Natto Extract Source – Max Strength Enzyme & Heart Health Support – Non-GMO

NatureBell Nattokinase Supplement 8,000 FU Per Serving, 240 Veggie Capsules | Traditional Natto Extract Source – Max Strength Enzyme & Heart Health Support – Non-GMO

Pure fermented Natto extract benefits.
High potency for heart health.
Non-GMO, safe, and tested.

Main Highlights

Max strength 8,000 FU Nattokinase per serving, sourced from a pure fermented Natto extract, a staple in centuries-old Japanese cuisines for trusted enzyme benefits.
240 high concentrated vegetarian capsules per bottle, 3 capsule serving size, ensuring 80 servings for optimal enzyme activity and heart health support.
Experience the natural enzyme benefits of Nattokinase that promote overall heart health, essential for maintaining daily wellness in both men and women.
NatureBell’s Nattokinase is derived from traditional Natto extract, ensuring you get the genuine benefits and high enzyme activity that has been valued for centuries.
Authentic non-GMO nattokinase supplements. Contains pure ingredients free of dairy, gluten, wheat, eggs, fish, preservatives, and tree nuts. All products are also 3rd party lab tested for safety and potency.

Liposomal Nattokinase 12,000 FU Serrapeptase 360,000 SPU Enzyme Supplement - Enriched with Synergistic Enzymes and Nutrient Blend & Inulin for Circulatory, Gut, Digestion 60 Capsules (1 Bottle)

Liposomal Nattokinase 12,000 FU Serrapeptase 360,000 SPU Enzyme Supplement - Enriched with Synergistic Enzymes and Nutrient Blend & Inulin for Circulatory, Gut, Digestion 60 Capsules (1 Bottle)

Superior absorption and bioavailability.
Advanced technology ensures optimal delivery.
Comprehensive wellness for all needs.

Main Highlights

Liposomal Nattokinase and Serrapeptase: Step into a new era of wellness with our groundbreaking liposomal nattokinase and serrapeptase
Maximum Absorption Liposomes Technology: This formula includes 12,000 FU of Nattokinase and 360,000 SPU of Serrapeptase, prepared using a liposomal delivery method. Developed with attention to formulation precision and ingredient selection, it reflects a focus on process quality and encapsulation design
Advanced Microbeadlet Technology: Our nattokinase and serrapeptase blend features a microbeadlet-based encapsulation process — developed as an alternative to conventional enteric coatings. This design reflects an ingredient-conscious approach to formulation, emphasizing consistency, precision, and innovation in supplement delivery
Nature Enzyme and Essential Elements Synergy Blend: Our formula includes 100mg of papain, curcumin, bromelain, rutin, and amla, along with 100mg of vitamin C, magnesium, vitamin B6, and calcium. It also features 100mg of inulin, combined with nattokinase and serrapeptase in a thoughtfully developed blend
Comprehensive Natural Wellness: Our nattokinase and serrapeptase supplement formula includes a curated combination of enzymes and complementary nutrients, developed using a liposomal format. The product is gluten-free, vegan-friendly, and free from artificial additives — offering flexibility for a variety of dietary preferences and formulation goals

Lunakai USA Made Nattokinase Supplement – 400mg Natto Enzyme, 8000 FU per Serving – Heart & Circulation Support – Non-GMO, 60ct, 4000 FU Capsule

Lunakai USA Made Nattokinase Supplement – 400mg Natto Enzyme, 8000 FU per Serving – Heart & Circulation Support – Non-GMO, 60ct, 4000 FU Capsule

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Supports healthy blood flow.
Vegan-friendly and plant-based.
Manufactured in the USA.

Main Highlights

Supports Circulation – Each serving delivers 8000 FU of nattokinase, traditionally sourced to assist in supporting normal blood flow.
Natural Heart Support – Our nattokinase supplement is formulated to complement daily routines focused on overall heart wellness support.
Clean & Simple Ingredients – Each capsule contains 200mg of nattokinase enzyme, delivering 4000 FU, sourced from fermented natto with no artificial flavors or additives.
Vegan-Friendly Formula – Our nattokinase supplement is 100% vegan and plant-based, with no animal-derived ingredients or gelatin.
Made in the USA – Manufactured in the United States in a facility that follows GMP (Good Manufacturing Practices) for quality and consistency.
Two Capsules per Day – A full daily serving consists of just two capsules, offering targeted nattokinase support in a simple regimen.
60 Capsules per Bottle – Each bottle provides a 30-day supply based on the recommended two-capsule daily intake.
Rooted in Tradition – Formulated with nattokinase derived from fermented soybeans, inspired by centuries-old Japanese natto practices.
Non-GMO and Gluten-Free – Formulated without genetically modified ingredients or gluten, making it suitable for various dietary preferences.
High-Strength Nattokinase 8000 FU – Each serving delivers 8000 FU of nattokinase enzyme activity, designed for those seeking a concentrated natto-based supplement.

Nattokinase Supplement 4,000 FU Servings, 120 Capsules (Derived from Japanese Natto) Systemic Enzymes for Cardiovascular and Circulatory Support by Double Wood

Double Wood Supplements

Nattokinase Supplement 4,000 FU Servings, 120 Capsules (Derived from Japanese Natto) Systemic Enzymes for Cardiovascular and Circulatory Support by Double Wood

Supports cardiovascular health effectively.
Promotes a healthy circulatory system.
High-quality, vegetarian, and gluten-free.

Main Highlights

CARDIOVASCULAR HEALTH: Nattokinase may help support a healthy circulatory system by lowering plasma levels of certain proteins that affect circulation
CIRCULATORY SUPPORT: Research suggests that Nattokinase may help support cardiovascular health by promoting a healthy circulatory system
DERIVED FROM SOY (JAPANESE NATTO): Since Nattokinase is derived from fermented soybeans (Japanese Natto), there may be trace amounts of soy in the product. Do not take it if you are allergic to soy
TWO-MONTH SUPPLY: Our Nattokinase supplement contains 60 servings of 200 mg (4,000 FU), which equals 120 capsules (100 mg, 2,000 FU per capsule)
ROOTED IN QUALITY: Double Wood's Nattokinase is manufactured right here in the USA from Globally Sourced Ingredients, Vegetarian, Non-GMO, and gluten-free

NOW Supplements, Nattokinase 100 mg (from Non-GMO Soy) with 2,000 FUs of Activity, 60 Veg Capsules

NOW Supplements, Nattokinase 100 mg (from Non-GMO Soy) with 2,000 FUs of Activity, 60 Veg Capsules

48% OffFree Shipping

Main Highlights

Now Foods

Nattokinase Supplement 4,000 FU Per Serving, 240 Veggie Capsules – Japanese Natto with Bromelain, Turmeric Curcumin & Black Pepper Complex – Digestive Enzymes & Heart Health – Non-GMO, Vegan

DEAL SUPPLEMENT

Nattokinase Supplement 4,000 FU Per Serving, 240 Veggie Capsules – Japanese Natto with Bromelain, Turmeric Curcumin & Black Pepper Complex – Digestive Enzymes & Heart Health – Non-GMO, Vegan

Extra strength for optimal health.
Supports heart and digestion wellness.
Non-GMO, gluten-free, quality assured.

Main Highlights

Special Features – 240 veggie capsules, extra strength 4,000 FU Nattokinase per serving in a 4-in-1 bioavailable complex, contains Bromelain, Turmeric, and Black Pepper for enhanced utilization of nutrients.
Benefits & Use – Supports heart and digestion health in men and women through a potent blend of authentic fermented Natto enzymes and herbal properties.
Supply & Servings – Every 2 capsule serving size provides 4,000 FU of Nattokinase, 50mg Bromelain with 2,400 GDU from a pineapple extract, 50mg Turmeric Curcumin from a 95% root extract, and 2.5mg Black Pepper extract.
Purpose – The enzymes from Nattokinase and Bromelain, as well as the herbal benefits of Turmeric and Black Pepper, promote a comprehensive spectrum of support.
Quality Ensured – Non-GMO ingredients that are 3rd party lab tested and passed. Made without gluten, dairy, eggs, peanuts, wheat, yeast, and tree nuts.