10 Best Nano Hydroxyapatite Toothpaste With Fluoride of 2025
Last updated on 09/03/2025
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Mouthology 10% Nano Hydroxyapatite Toothpaste (Fluoride Free), Whitening*, Supports Enamel Care*, Appropriate for Sensitive Teeth*, SLS Free, Xylitol nHA Toothpaste for Adults, Mint 4oz (USA Made)
Mouthology
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Mouthology
Mouthology 10% Nano Hydroxyapatite Toothpaste (Fluoride Free), Whitening*, Supports Enamel Care*, Appropriate for Sensitive Teeth*, SLS Free, Xylitol nHA Toothpaste for Adults, Mint 4oz (USA Made)
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Why We Love It
- NASA-inspired enamel repair technology.
- Clinically proven 10% effectiveness.
- Fluoride-free and safe for everyone.
Main Highlights
- 10% NANO-HYDROXYAPATITE: Our toothpaste features 10% nano-hydroxyapatite (n-HA), a calcium-based compound used in Japan for decades in oral care. Known for its smooth feel and gentle cleaning, n-HA is an alternative to fluoride for those who prefer fluoride-free options. n-HA is a remarkable biomaterial that comprises 60-70% of bone mass and an astounding 96% of tooth enamel, making it the hardest substance in the human body.
- WHY 10% SPECIFICALLY?: Unlike other brands that hide their Nano-Hydroxyapatite percentages, our toothpaste contains the full 10% Nano Hydroxyapatite—the optimal amount concluded my most scientific studies. Too little is ineffective, and too much nHA starts to aggregate (or "clump" together) also reducing efficacy.
- THAT CLEAN DENTIST FEELING: Say goodbye to harsh bleaching agents. Our nano hydroxyapatite toothpaste gently polishes, leaving you with a glossier, smoother "tooth feel" without causing sensitivity.
- FLUORIDE FREE & SAFE FOR ALL AGES: Our nano hydroxyapatite toothpaste is completely fluoride-free, offering a safe alternative for those looking to avoid the negative health concerns of fluoride. Our nHa toothpaste is made with biocompatible ingredients, safe if swallowed and recommended by dentists nation-wide.
- MADE IN USA WITH CLEAN INGREDIENTS: Made in the USA with premium, globally sourced ingredients. Our toothpaste is fluoride-free, SLS-free, with birch xylitol to promote oral health. No artificial colors or flavors. No Triclosan. No Titanium Dioxide. Just clean, gentle care for your mouth.
- Whitening* = *Based on the cleaning and polishing action of the toothpaste; no claim of altering tooth color or providing a bleaching effect.
- Supports Enamel Care* = **Based on the properties of nano-hydroxyapatite as reported in published research; no claim of specific clinical outcomes for this product.
Value for Money
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Made by Dentists Professional Enamel Rebuilding Toothpaste - 2 Pack - Remineralizing Nano Hydroxyapatite Toothpaste with Sodium Fluoride, ADA Approved, Vegan, 2 x 4.2oz
Made by Dentists
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Made by Dentists
Made by Dentists Professional Enamel Rebuilding Toothpaste - 2 Pack - Remineralizing Nano Hydroxyapatite Toothpaste with Sodium Fluoride, ADA Approved, Vegan, 2 x 4.2oz
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Why We Love It
- Advanced enamel rebuilding technology.
- Effective relief from tooth sensitivity.
- Vegan and eco-friendly formula.
Main Highlights
- Advanced Enamel Rebuilding: This hydroxyapatite toothpaste contains nano hydroxyapatite and fluoride to replenish and remineralize enamel, making teeth stronger and harder.
- How It Works: Utilizes nano-sized Hydroxyapatite particles that penetrate deeply into the tooth to remineralize from within, restoring the natural strength of enamel.
- Protects Against Sensitivity: This remineralizing toothpaste contains potassium nitrate to block sensitive pathways in your teeth, providing relief from discomfort while strengthening enamel.
- ADA Approved: Officially recognized by the American Dental Association for its effectiveness in enamel restoration and cavity prevention.
- Vegan, Cruelty-Free, & Eco-Friendly: A vegan-friendly formula that's also cruelty-free, with packaging made from 100% recyclable materials.
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Dr. Jen Super Paste/Toothpaste with Fluoride +10% Nano-Hydroxyapatite Travel Toothpaste for Teeth Whitening & Sensitive Teeth Care (3.4 Ounce (Pack of 1), Cool Mint)
Dr Jen
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Dr Jen
Dr. Jen Super Paste/Toothpaste with Fluoride +10% Nano-Hydroxyapatite Travel Toothpaste for Teeth Whitening & Sensitive Teeth Care (3.4 Ounce (Pack of 1), Cool Mint)
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Why We Love It
- Clinically proven for effective results.
- Deep repair for long-lasting health.
- Optimal mineral uptake for defense.
Main Highlights
- Clinically Proven 10% Nano-Hydroxyapatite — The Gold Standard for Maximum Mineral uptake. Formulated with the optimal 10% concentration of nano-Hydroxyapatite, shown to deliver the highest levels of calcium and phosphate uptake into enamel for unmatched cavity defense and enamel repair.
- Premium-Grade Nano-Hydroxyapatite for Deep Repair Below the Surface. Our ultra-fine, medical-grade nano-Hydroxyapatite penetrates deep into enamel and dentin micro-channels, restoring mineral content where decay starts—beneath the surface.
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Dr. Jen's 10% Nano Hydroxyapatite Toothpaste - Fluoride Free, Xylitol Toothpaste
Dr Jen
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Dr Jen
Dr. Jen's 10% Nano Hydroxyapatite Toothpaste - Fluoride Free, Xylitol Toothpaste
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Why We Love It
- Clinically proven for effective repair.
- Deep penetration for lasting protection.
- Optimal mineral uptake for strong enamel.
Main Highlights
- 10(nHp): Our unique formulation includes a potent 10% Nano-Hydroxyapatite for proven enamel remineralization, and it's gentle on young teeth and gums thanks to xylitol with a low abrasiveness (RDA 38). Encourage your kids to use it twice daily for a smile that's both healthy and fun. Elevate their oral care with science-backed excellence, specially crafted for little ones!
- Xylitol Toothpaste: Xylitol disrupts the growth of bacteria in the mouth, particularly Streptococcus mutans, which is a primary culprit in tooth decay. These bacteria feed on sugars from the food we eat and produce acids that erode tooth enamel, leading to cavities. However, when exposed to Xylitol, these bacteria are unable to metabolize it effectively, reducing their ability to cause harm to the teeth.
- Sensitive Toothpaste: the inclusion of aqua (water) and glycerin derived from coconut in toothpaste contributes to its effectiveness in cleaning and protecting the teeth and gums, while also providing a pleasant texture and flavor during use.
- Remineralizing Toothpaste: Calendula extract is obtained by extracting the beneficial compounds from the petals of the calendula flower. This Proven ingredient is often preferred in toothpaste formulations due to its gentle nature and effectiveness in promoting gum health.
- Fluoride-Free: While fluoride is beneficial for preventing tooth decay in adults, excessive fluoride intake in children can lead to dental fluorosis, a condition characterized by discoloration and mottling of the teeth. PureSmile Kids is fluoride-free, providing a safe option for young children who may be at risk of ingesting toothpaste.
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APAGARD® PREMIO, Sangi's Nano-Hydroxyapatite Toothpaste for Naturally Whiter Teeth, No Fluoride, For family use, 105g / 3.7 Oz, Double Mint, Pack of 2
APAGARD
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APAGARD
APAGARD® PREMIO, Sangi's Nano-Hydroxyapatite Toothpaste for Naturally Whiter Teeth, No Fluoride, For family use, 105g / 3.7 Oz, Double Mint, Pack of 2
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Why We Love It
- Naturally beautiful teeth enhancement.
- Effective plaque removal formula.
- Family-friendly for all ages.
Main Highlights
- APAGARD, Japan's leading toothpaste series for naturally beautiful teeth, is now available in the US. Discover the secret of naturally beautiful teeth from Japan. Contains Sangi's original nano-hydroxyaptite (nano-mHAP), almost the same substance as the hydroxyapatite that our teeth are made of, first synthesized in the 1970s by Sangi Co., Ltd
- APAGARD cleans the teeth and helps remove plaque with regular brushing.
- APAGARD M-plus is the standard, classic version and longest-selling product in the APAGARD range. It offers an all-around balance between natural whiteness enhancement, breath care, and stain control, and is suited for all ages, coming in a higher volume package, ideal for family use.
- For the best effect from nano-mHAP toothpaste, we recommend that you (1) Place a small amount (1-1.5 cm) on a toothbrush. (2) Brush your teeth and gums gently but meticulously for about 3-5 minutes, ideally after each meal (3 times/day is recommended) (3) Rinse lightly and spit out after brushing, so nano-mHAP remaining will enrich your saliva and continue its work.
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CariFree Gel 1100 (Mint) Anti-Cavity Fluoride Toothpaste with Nano Hydroxyapatite, Cavity Prevention and Enamel Protection, Dentist Recommended for Kids and Adults, 2.40 oz.
CariFree
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CariFree
CariFree Gel 1100 (Mint) Anti-Cavity Fluoride Toothpaste with Nano Hydroxyapatite, Cavity Prevention and Enamel Protection, Dentist Recommended for Kids and Adults, 2.40 oz.
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Why We Love It
- Dentist-recommended for cavity prevention.
- Real mint flavor for fresh taste.
- Proudly made in the USA.
Main Highlights
- Dentist-Recommended Fluoride Toothpaste: CariFree Fluoride Gel is recommended by dentists to help prevent cavities and promote good dental health. Fluoride is a key ingredient that strengthens tooth enamel and helps protect against decay. By using this toothpaste regularly, you can give your teeth an added layer of protection against cavities.
- Real Mint Flavor: CariFree uses genuine mint oil to create a real, fresh taste that is safe to use every day. Our Gel is also made with xylitol, a naturally occurring, sweet-tasting ingredient found in many types of plants that research shows may reduce your risk of dental cavities.
- Nano Hydroxyapatite: CariFree Gel 1100 contains nanoXIM by FlUIDINOVA, the highest quality nano hydroxyapatite that's the same shape and size as the naturally occurring hydroxyapatite found in saliva. Our toothpaste is a low-abrasion tooth gel that combines proven anti-cavity benefits, including .24% fluoride, nano hydroxyapatite and our unique, patented pH+ technology to neutralize acids—recommended for ages 3+
- Fight Cavities and Promote Fresh Breath: CariFree Gel 1100 contains 0.24% sodium fluoride to fight cavities and help prevent tooth decay while also freshening your breath. With patented pH+ technology, CariFree toothpaste is designed to target the root cause of cavities while also leaving your breath minty fresh.
- Proudly Manufactured in the USA: CariFree products are meticulously formulated and produced in the USA, utilizing both domestic and globally sourced ingredients that showcase our commitment to domestic quality and local craftsmanship. Founded in Albany, Oregon, CariFree is dedicated to providing affordable, science-based solutions for common dental health concerns that benefit the entire family.
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SuperMouth Fluoride Toothpaste - Adults & Kids, Fights Cavities, Whitens, Nano Hydroxyapatite, Dentist Developed, Safe Clean Ingredients, Gentle on Sensitive Teeth, Vitamins D3 & K2, 4 Tasty Flavors
SuperMouth
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SuperMouth
SuperMouth Fluoride Toothpaste - Adults & Kids, Fights Cavities, Whitens, Nano Hydroxyapatite, Dentist Developed, Safe Clean Ingredients, Gentle on Sensitive Teeth, Vitamins D3 & K2, 4 Tasty Flavors
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Why We Love It
- Powerful cavity protection formula.
- Gentle for sensitive teeth.
- Delicious flavors for enjoyable brushing.
Main Highlights
- Dual Power of Fluoride & Liquid Enamel Technology️ for Maximum Protection: Pair the cavity-fighting benefits of fluoride with our patented Liquid Enamel Technology️—a proprietary blend of 10%+ nano-hydroxyapatite, vitamins D3 & K2, and an alkaline pH—to help strengthen enamel, ease sensitivity, support gum health, and protect against cavities. Designed with optimal ingredient concentrations for maximum efficacy, it’s a powerful choice for both adults and kids.
- Perfect for Sensitive Teeth & Microbiome Support: Our low Relative Dentin Abrasivity (RDA) of 67 and alkaline pH mean gentle yet effective cleaning, making it an ideal choice for those with sensitive teeth. Free from potent essential oils that can disturb the mouth’s natural balance, SuperMouth supports your oral microbiome while promoting a calmer, healthier environment for teeth and gums.
- Delicious Flavors that Make Brushing Enjoyable: Turn daily brushing into a treat with four family-favorite flavors—Smooth Vanilla, Creamy Strawberry, Decadent Chocolate, and Fresh Mint. Our specially formulated spearmint avoids the burning sensation or aftertaste often linked to peppermint oils, delivering a refreshing but gentle experience that encourages consistent brushing for kids and adults alike.
- Whitens Teeth for a Radiant Smile: Helps minimize surface stains and reveals a brighter smile thanks to the combined action of fluoride and nano-hydroxyapatite. Formulated with xylitol and prebiotics, this forward-thinking approach supports overall mouth health by promoting enamel integrity, helping you maintain confidence in every grin.
- Clean, Expertly Developed, & Sustainably Packaged: Rely on a toothpaste free from artificial flavors, colors, sweeteners, SLS, titanium dioxide, and other potentially harsh additives. Dentist-developed and made in the USA with globally sourced premium ingredients, SuperMouth is vegan, gluten-free, and packaged with sustainable materials—so you can protect your teeth, gums, and the planet every time you brush.
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SuperMouth Nano Hydroxyapatite Toothpaste – Fluoride-Free, Remineralizing, Vitamins D3 & K2, Eases Sensitivity, Whitens, Dentist-Developed, Clean Ingredients, Adults & Kids, 4 Flavors
SuperMouth
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SuperMouth
SuperMouth Nano Hydroxyapatite Toothpaste – Fluoride-Free, Remineralizing, Vitamins D3 & K2, Eases Sensitivity, Whitens, Dentist-Developed, Clean Ingredients, Adults & Kids, 4 Flavors
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Why We Love It
- Supports healthier teeth and enamel.
- Whitening without harsh chemicals.
- Ideal for sensitive mouths.
Main Highlights
- Support Healthier Teeth & Enamel with Our Patented Liquid Enamel Technology️: This advanced formula combines the effectiveness of traditional toothpaste with the safety and cleanliness of a natural toothpaste—giving you the best of both worlds. Powered by our proprietary Liquid Enamel Technology️, it features at least 10% nano-hydroxyapatite, vitamins D3 & K2, prebiotics, and an alkaline pH to help strengthen enamel, minimize plaque, and support a healthy oral microbiome—all without fluoride.
- Whiten & Boost Resilience: Elevate your smile’s brightness and overall resilience with our unique blend of safe, effective ingredients—formulated at optimal concentrations—to minimize the appearance of surface stains and support gum health, all without fluoride. By focusing on gentle cleaning and supporting your mouth’s natural balance, SuperMouth helps keep your teeth looking radiant and feeling strong every day.
- Ideal for Sensitive Teeth & Supporting Your Oral Microbiome: Our low-abrasion (RDA 67), alkaline pH formula gently cleans without wearing down enamel, making it a perfect choice for those with sensitive teeth. Free from potent essential oils that can disrupt the natural balance of the oral microbiome, SuperMouth promotes healthier gums, fostering a calmer, more balanced environment for a healthier mouth overall.
- Long-Lasting Freshness, Gentle Foaming, & Flavors for Every Palate: Experience a light, yet effective foaming process that cleans thoroughly—without harsh foaming agents—for an all-day fresh feeling. Enjoy one of our four family-favorite flavors—Smooth Vanilla, Creamy Strawberry, Decadent Chocolate, and Fresh Mint—without the burn or bitter aftertaste often associated with peppermint oil, making brushing fun for kids and soothing for adults.
- Clean, Safe, & Expertly Crafted: Trust in a toothpaste that’s free from SLS, titanium dioxide, artificial colors, artificial flavors, artificial sweeteners, irritants, and other potentially harsh additives. Developed by leading dental professionals and proudly made in the USA with globally sourced premium ingredients, SuperMouth balances safety, and effectiveness with sustainable packaging—so you can protect your teeth, gums, and the planet, all in one step.
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NOBS (No Bad Stuff) Toothpaste Tablets - Nano Hydroxyapatite, Fluoride & Plastic Free, Eco & Travel Friendly - Remineralize with NHA (1 Month)
NOBS
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NOBS
NOBS (No Bad Stuff) Toothpaste Tablets - Nano Hydroxyapatite, Fluoride & Plastic Free, Eco & Travel Friendly - Remineralize with NHA (1 Month)
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Why We Love It
- Fluoride-free for healthier teeth.
- Ecofriendly glass packaging option.
- Perfect for hassle-free travel.
Main Highlights
- FLUORIDE-FREE AND REMINERALIZING! Harnessing the power of nanohydroxyapatite for long-term protection, and leaving a refreshing minty aftertaste.
- ECOFRIENDLY PACKAGING! Conveniently housed in a plastic-free glass jar, we're the go-to for a no plastic toothpaste tablet.
- TRAVEL WITH CONFIDENCE! NOBS tablets bypass the TSA's 3.4oz liquid limit, ensuring hygienic, stress-free travel.
- CHAMPIONING ENVIRONMENTAL STEWARDSHIP! At Biom, we create fluoride-free toothpaste tablets that are free of plastics and BPAs.
- EXPERIENCE THE NOBS REVOLUTION TODAY! The ultimate choice for a refreshing, effective, and ecofriendly oral care solution. Say hello to radiant smiles and fresh breath.
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NOBS Jr. Kids Nano Hydroxyapatite Toothpaste – Fluoride Free, SLS-Free, Remineralizing - Dentist Formulated - Bubblegum Berry
Biöm
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Biöm
NOBS Jr. Kids Nano Hydroxyapatite Toothpaste – Fluoride Free, SLS-Free, Remineralizing - Dentist Formulated - Bubblegum Berry
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Why We Love It
- Gentle on sensitive skin.
- Ethically sourced ingredients only.
- Sustainable and responsible packaging.
Main Highlights
- Free from harsh chemicals
- Cruelty-free and vegan
- Eco-friendly packaging
- Proudly made in the USA
- 5% Nano Hydroxyapatite