10 Best Medical Cream For Very Dry Itchy Skin On Legs of 2025

Last updated on 07/16/2025

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Oleavicin Organic Extra Strength Anti-Itch Cream for Dry, Itchy Skin Relief – Natural Fungal & Rash Treatment with Olive Leaf Extract – Fast-Acting, Long-Lasting Itch Relief

Oleavicin Organic Extra Strength Anti-Itch Cream for Dry, Itchy Skin Relief – Natural Fungal & Rash Treatment with Olive Leaf Extract – Fast-Acting, Long-Lasting Itch Relief

Powerful natural soothing relief.
Deep moisturizing for all skin.
Safe for sensitive skin types.

Main Highlights

Powerful Natural Relief: Formulated with organic olive leaf extract, known for its soothing properties to alleviate dry, itchy, and irritated skin.
Deep Moisturizing & Hydration: Infused with aloe vera and vitamins, this fast-absorbing cream promotes skin barrier health, reducing redness and irritation.
Steroid-Free & Safe for All: Gentle, non-toxic formula free from steroids, parabens, and harsh chemicals — perfect for sensitive skin, adults, and kids.
Fast-Acting, Long-Lasting Comfort: Provides quick relief for bites, rashes, ivy, and fungal irritation with no greasy residue.
Travel-Friendly & Multi-Purpose: Ideal for daily skincare, minor burns, insect bites, and outdoor first aid — a must-have for your home or travel kit.

Medline Remedy Specialized Skin Cream (32 oz Bottle), Scented, 1.5% Dimethicone, Nourishing Moisturizer for Dry Skin, Sulfate-Free, Paraben-Free, Hypoallergenic Body Cream, Daily Lotion for Dry Skin

Medline Remedy Specialized Skin Cream (32 oz Bottle), Scented, 1.5% Dimethicone, Nourishing Moisturizer for Dry Skin, Sulfate-Free, Paraben-Free, Hypoallergenic Body Cream, Daily Lotion for Dry Skin

Restores natural moisturization effectively.
Nourishes and repairs dry skin.
Absorbs quickly with no residue.

Main Highlights

Medline Remedy Intensive Skin Therapy Skin Repair Cream has a unique ceramide formula to help restore natural moisturization and moisture protection. Packaging may Vary
A rich blend of natural, moisturizing emollients nourishes, relieves, and helps to repair dry, cracked skin
Skin Repair Cream absorbs readily into the skin upon application with no greasy residue | Light, fresh, orange vanilla scent
Paraben-free, hypoallergenic, CHG compatible, pediatrician tested and for all ages

Wild Naturals Eczema & Psoriasis Cream for Dry, Itchy Skin – Eczema Relief for Adults & Kids – Moisturizing Psoriasis Cream with Manuka Honey

Wild Naturals Eczema & Psoriasis Cream for Dry, Itchy Skin – Eczema Relief for Adults & Kids – Moisturizing Psoriasis Cream with Manuka Honey

20% OffFree Shipping

Penetrates deeply for hydration.
Soothes and protects damaged skin.
Gentle and safe for everyone.

Main Highlights

Soothe, Hydrate, & Nourish: Wild Naturals eczema relief & psoriasis cream penetrates deeply to deliver a powerful boost of hydration and nourishment, leaving skin balanced and healthy. This psoriasis lotion & eczema honey cream is specially formulated with soothing & hydrating aloe vera as its base ingredient, not water like most skincare products.
Protects & Moisturizes Dry, Damaged Skin: Our seborrheic dermatitis itch relief cream & eczema body lotion are enriched with powerful manuka honey from New Zealand. Packed with a unique blend of vitamins, minerals, & amino acids from UMF 12+ manuka honey, this itchy skin relief lotion for eczema & dermatitis cream naturally seals in moisture to protect & restore dry, damaged skin.
Safe, Gentle, & pH-Balanced Formula: This eczema face cream & anti-itch lotion is perfectly pH-balanced at 5.5 to mimic your skin’s natural pH level, which means it will be easily absorbed without irritating your skin. Our baby eczema lotion & seborrheic dermatitis cream is gentle for all skin types, even for those with very sensitive skin. No harsh & filler ingredients. 100% steroid-free!
Lightweight & Non-Greasy: Our eczema relief cream provides fast-acting relief for your face, body, hands, feet, or scalp. Our eczema cream soaks right in, leaving your skin feeling nourished & rejuvenated. No petroleum ingredients. Free of parabens, gluten, dyes, & artificial colors. Cruelty-free & 100% made in the USA!
Our products are carefully formulated using the finest ingredients. We understand that your skin deserves nothing but the best, & we strive to deliver just that.

Medline Remedy Clinical Skin Cream, Nourishing Formula for Dry Skin, 32 oz. Pump Bottle

Medline Remedy Clinical Skin Cream, Nourishing Formula for Dry Skin, 32 oz. Pump Bottle

Safe for healthcare professionals.
Deep and non-greasy hydration.
Gentle on all skin types.

Main Highlights

CHG Compatible Formula: Helps provide safe use for healthcare workers, maintaining skin moisture even under gloves, ideal for frequent hand-washing environments
Natural Emollient Formula: Infused with safflower oleosomes to provide deep, non-greasy hydration suitable for all skin types
Gentle Formula: Carefully formulated to be gentle, avoiding common irritants
Proprietary Nutrient Blend: Cream is enhanced with Remedy nutrient complex, additional botanicals, and essential fatty acids
Convenient Large Size: The 32 oz. pump bottle offers ease of use and ample product, making it a practical choice for both home and healthcare settings

Dr Hess Skin Moisturizer For Diabetic Prone Skin, Nourishing, Moisturizing Body Lotion with Lanolin, Beeswax, Jojoba Oil & Olive Oil, Skin Moisturizer for Dry, Itchy, Rough & Bumpy Skin, 4oz - 2 Pack

Dr Hess Skin Moisturizer For Diabetic Prone Skin, Nourishing, Moisturizing Body Lotion with Lanolin, Beeswax, Jojoba Oil & Olive Oil, Skin Moisturizer for Dry, Itchy, Rough & Bumpy Skin, 4oz - 2 Pack

Natural ingredients nourish skin.
Intense hydration for dry skin.
Dermatologist recommended for safety.

Main Highlights

Diabetic Prone Skin Care - Specially formulated with natural ingredients like Olive Oil and Jojoba Oil to target sensitive diabetic skin types, providing nourishment and hydration
Intense Hydration: Dr Hess Skin Moisturizer is formulated with key ingredients such as Lanolin, Beeswax, and Vitamin E to lock in existing moisture, absorb additional moisture from the air, and provide necessary antioxidants for deep healing; Ideal for dry, damaged, and diabetic prone skin
Soothes & Protects: Olive Oil's high content of healing Vitamin E and fatty acids helps soothe and protect your skin from irritation or scaly and rough patches; Intensive moisturization with Lanolin and Beeswax which can absorb additional moisture from the air, ensuring your skin stays hydrated and soft
Dermatologist Recommended: Developed with the help of dermatologists, our moisturizer is cruelty-free, paraben-free, sulfate-free, BPA-free, and phthalate-free, ensuring a safe and effective solution for your skin care needs
Since 1893: For over a century, the Dr. Hess brand has carried forward the legacy of science-backed, natural formulations, many of which have been shown to be effective for generations; The goal remains unchanged: to provide effective solutions for pervasive skin issues, benefiting people worldwide

Puriya National Eczema Association Accepted Cream 2 oz, Dry Itchy Skin Relief, Colloidal Oatmeal Lotion, For Kids, Adults, Face, Hands, Mother of All Creams, Plant-Based Hydration,No Fragrance Added

Puriya National Eczema Association Accepted Cream 2 oz, Dry Itchy Skin Relief, Colloidal Oatmeal Lotion, For Kids, Adults, Face, Hands, Mother of All Creams, Plant-Based Hydration,No Fragrance Added

Intensely hydrates and nourishes skin.
Fast relief for itchy skin.
Controls flare-ups effectively and gently.

Main Highlights

Hydrates and Softens Dry, Rough Skin: Packed with nutrient dense natural botanicals and intensely moisturizing oils, this formula is designed to soothe, and dramatically improve the appearance of skin
Fast Acting Itch Relief: Our plant-based cream is ultra hydrating and soothing to dry itchy skin. It's accepted by National Eczema Association and made for extremely sensitive skin
Helps Control Flare-Ups: Powered by amaranth seed oil and shea butter to nourish the skin's barrier, hyaluronic acid to lock in moisture, and MSM to boost the effectiveness of the ingredients
Healthy Skin that Lasts: Formulated with science-backed ingredients that are clinically studied to support the continued maintenance of healthy skin
Accelerate Your Results: Purchase this gentle yet highly effective moisturizer to intensely nourish and hydrate dry, itchy, cracked skin. Or get our complete 3-Step Sensitive Skin System to accelerate results and reclaim your soft healthy skin

Medline Remedy Specialized Skin Cream, Fragrance-Free (16 oz), 1.5% Dimethicone, Nourishing Moisturizer for Dry Skin, Sulfate-Free, Paraben-free, Hypoallergenic Body Cream, Daily Lotion for Dry Skin

Medline Remedy Specialized Skin Cream, Fragrance-Free (16 oz), 1.5% Dimethicone, Nourishing Moisturizer for Dry Skin, Sulfate-Free, Paraben-free, Hypoallergenic Body Cream, Daily Lotion for Dry Skin

Improved formula for better results.
Nourishes and revitalizes skin.
Hypoallergenic and paraben-free.

Main Highlights

NEW IMPROVED FORMULA AND LOOK AND NAME: Previously REMEDY DERMATOLOGY SERIES MOISTURIZING CREAM, this cream has been improved with a slight change in the formula to make this product even better. Remedy is the #1 skin care brand in healthcare.
NOURISHING TARGETED CARE: This fragrance-free body cream contains 1.5% dimethicone that helps alleviate skin dryness and revitalize skin to its natural beauty. It is clinically formulated for a deeper level of skin care.
NATURAL EMOLLIENTS: Enriched with a premium blend of natural emollients and phospholipids, skin care experts carefully developed this formula for dry skin to restore extremely dry and chapped skin.
MOISTURIZING CREAM: Our product serves as an overall moisturizer for dry skin that provides soothing care for the entire body. It has a premium, solution-based gentle formulation. Hypoallergenic, Paraben-free, pH Balanced.
REMEDY NUTRIENT COMPLEX: Experience the nourishing benefits of our proprietary blend of Remedy Nutrient Complex with nutrient-based ingredients. This naturally derived blend is designed to provide a gentle moisturizing regimen for sensitive skin.

A and D Ointment By Sion Biotext Baby Diaper Rash Vitamin A + D Original Healing Cream Medical Moisturizer Intensive Therapy For Dry & Irritated Skin, Cuts, Burns Soothing Baby Care 144 packets

A and D Ointment By Sion Biotext Baby Diaper Rash Vitamin A + D Original Healing Cream Medical Moisturizer Intensive Therapy For Dry & Irritated Skin, Cuts, Burns Soothing Baby Care 144 packets

Main Highlights

Diaper Rashes Rich in vitamins A and D and it’s been specially formulated to treat your baby’s sensitive skin. This diaper rash cream will soothe the rash, and nourish, relief, moisturize and fortify your baby’s gentle skin.
A Multipurpose Ointment This skin therapy ointment can be used to treat many different kinds of skin issues on the Face and bum. For minor cuts, scrapes, burns, cracked skin, and dry lips.
Safe Soothing Ingredients: Diaper rash cream is made of 5 incredibly nourishing and moisturizing ingredients, White Petrolatum Lanolin, Vitamin A, Vitamin D, Paraffin, and Lavender Oil, The ointment is absolutely safe for your baby.
Get The Value Pack for your convenience, they come in small packets to keep them sterile for single-time use. The Sion Biotext maximum value pack includes 144 individual foil packets (0.2 oz each) to take with you anywhere you go.

CeraVe Moisturizing Cream for Diabetics’ Dry Skin, Urea Cream with Bilberry for Face and Body, Fragrance Free & Paraben Free, 8 Ounce

CeraVe Moisturizing Cream for Diabetics’ Dry Skin, Urea Cream with Bilberry for Face and Body, Fragrance Free & Paraben Free, 8 Ounce

Non-greasy and fast-absorbing.
Provides long-lasting hydration.
Gentle and suitable for sensitive skin.

Main Highlights

[ DIABETIC DRY SKIN CREAM ] Non-greasy, fast-absorbing CeraVe Moisturizing Cream for those with dry skin from Diabetes. Moisturizes & helps to soothe diabetics’ dry skin at application. 90% of users tested said that their skin felt immediately smoother.
[ 48-HOUR HYDRATION ] Formulated with Urea to help attract and retain moisture and Bilberry as a source of antioxidants. Features patented MVE Technology to deliver hydrating ingredients throughout the day and provide 48 hour moisturization.
[ GENTLE ON SKIN ] Fragrance free, paraben-free, non-comedogenic, and free of drying alcohol
[ 3 ESSENTIAL CERAMIDES ] Ceramides are found naturally in the skin and make up 50% of the lipids in the skin barrier. All CeraVe products are formulated with three essential ceramides (1, 3, 6-II) to help restore and maintain the skin’s natural barrier
[ DEVELOPED WITH DERMATOLOGISTS ] CeraVe Skincare is developed with dermatologists and has products suitable for dry skin, sensitive skin, oily skin, acne-prone, and more.

Curel Itch Defense Calming Body Lotion, Moisturizer for Dry, Itchy Skin, Body and Hand Lotion, with Advanced Ceramide Complex, Pro-Vitamin B5, Shea Butter, 20 Oz

Curel Itch Defense Calming Body Lotion, Moisturizer for Dry, Itchy Skin, Body and Hand Lotion, with Advanced Ceramide Complex, Pro-Vitamin B5, Shea Butter, 20 Oz

6% OffFree Shipping

Clinically proven relief from itching.
Restores skin's moisture barrier.
Soothes eczema-prone skin effectively.

Main Highlights

SAFE FOR MOST SKIN TYPES - Suitable for use on babies 6 months and up