10 Best Itch Relief Cream of 2025

Last updated on 07/16/2025

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CeraVe Moisturizing Cream for Dry Skin Relief, 12 Ounce, Fragrance Free Cream with Pramoxine for Itch Relief

CeraVe Moisturizing Cream for Dry Skin Relief, 12 Ounce, Fragrance Free Cream with Pramoxine for Itch Relief

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Fast-acting itch relief.
Moisturizes dry skin effectively.
Dermatologist-developed for sensitive skin.

Main Highlights

[ CERAVE ANTI ITCH CREAM ] Temporarily relieves itching associated with insect bites, sunburn, poison ivy while moisturizing dry skin. Rich, velvety texture that is absorbed quickly for softened skin with non-greasy feel.
[ CLINICALLY TESTED ] Provides relief within two minutes and lasts up to 8 hours. 100 percent of people experienced relief for even their most severe itch; clinical study done on 34 subjects. Individual results may vary.
[ SOOTHING INGREDIENTS ] Formulated with 1% Pramoxine Hydrochloride for fast-acting, long-lasting temporary itch-relief, Niacinamide to help calm skin, and Hyaluronic Acid to help retain skin’s natural moisture.
[ 3 ESSENTIAL CERAMIDES ] Ceramides are found naturally in the skin and make up 50% of the lipids in the skin barrier. All CeraVe products are formulated with three essential ceramides (1, 3, 6-II) to help restore and maintain the skin’s natural barrier
[ DEVELOPED WITH DERMATOLOGISTS ] Suitable for use on face, body, and hands to temporarily relieve itching. Holds National Eczema Association (NEA) Seal of Acceptance. Fragrance free, steroid-free, and non-comedogenic. FSA Eligible & HSA Eligible

CeraVe Anti Itch Moisturizing Lotion with Pramoxine Hydrochloride, Relieves Itch with Minor Skin Irritations, Sunburn Relief, Bug Bites, 8 Ounce

CeraVe Anti Itch Moisturizing Lotion with Pramoxine Hydrochloride, Relieves Itch with Minor Skin Irritations, Sunburn Relief, Bug Bites, 8 Ounce

Rapid itch relief within minutes.
Formulated with soothing ingredients.
Developed with dermatologists' expertise.

Main Highlights

[ CERAVE ANTI ITCH LOTION ] Temporarily relieves itching associated with insect bites, sunburn, poison ivy while moisturizing dry skin. Lightweight texture that is absorbed quickly for softened skin with non-greasy feel.
[ CLINICALLY TESTED ] Provides relief within two minutes and lasts up to 8 hours. 100 percent of people experienced relief for even their most severe itch; clinical study done on 34 subjects. Individual results may vary.
[ SOOTHING INGREDIENTS ] Formulated with 1% Pramoxine Hydrochloride for fast-acting, long-lasting temporary itch-relief, Niacinamide to help calm skin, and Hyaluronic Acid to help retain skin’s natural moisture.
[ 3 ESSENTIAL CERAMIDES ] Ceramides are found naturally in the skin and make up 50% of the lipids in the skin barrier. All CeraVe products are formulated with three essential ceramides (1, 3, 6-II) to help restore and maintain the skin’s natural barrier
[ DEVELOPED WITH DERMATOLOGISTS ] Suitable for use on face; body; and hands to temporarily relieve itching. Holds National Eczema Association (NEA) Seal of Acceptance. Fragrance free; steroid-free; and non-comedogenic. FSA Eligible & HSA Eligible

Aveeno Eczema Therapy, Nighttime Itch Relief Balm for Body, Moisturizing Colloidal Oatmeal & Ceramide Formula, Fragrance & Steroid-Free, Soothing Dry Itchy Skin, 11 fl oz

Aveeno Eczema Therapy, Nighttime Itch Relief Balm for Body, Moisturizing Colloidal Oatmeal & Ceramide Formula, Fragrance & Steroid-Free, Soothing Dry Itchy Skin, 11 fl oz

25% OffFree Shipping

Instant relief for itchy skin.
Gentle formula for sensitive skin.
Recommended by dermatologists everywhere.

Main Highlights

Eczema cream for adults: Provides targeted itch relief due to eczema cream benefits; formulated with colloidal oatmeal and ceramide for intense overnight moisture and itchy skin relief on dry, sensitive skin. 11 fl oz tub offers full-body coverage
Moisturizing balm for body: The itch relief balm delivers long-lasting moisture and replenishes the skin’s natural moisture barrier; suitable for nightly use to soothe dry, itchy, sensitive skin and support eczema-prone areas
Colloidal oatmeal: Formula contains ingredients to help relieve minor skin irritation due to eczema; accepted by the National Eczema Association, suitable for sensitive skin and provides immediate and long-lasting itch relief
Formulated for sensitive skin: It is non-greasy, and allergy-tested; free from steroids, parabens, fragrances, and dyes; suitable for use on adults with sensitive or eczema-prone skin. Incorporate the body balm into your nightly skincare routine
Colloidal oatmeal skin protectant: Nighttime itch relief balm offers soothing relief for itchy, irritated, and dry skin. Suitable for use on adults or those seeking a fragrance-free, steroid-free solution for itch relief due to eczema

Aquaphor Itch Relief Ointment, Maximum Strength 1% Hydrocortisone, Relieves Itch from Skin Irritation, Insect Bites, Psoriasis, Skin Rashes, Eczema, & Poison Ivy, 2 oz

Aquaphor Itch Relief Ointment, Maximum Strength 1% Hydrocortisone, Relieves Itch from Skin Irritation, Insect Bites, Psoriasis, Skin Rashes, Eczema, & Poison Ivy, 2 oz

Long-lasting itch relief guaranteed.
Clinically proven outdoor irritation remedy.
Soothes various indoor skin issues.

Main Highlights

Long Lasting Itch Relief: Aquaphor Itch Relief ointment soothes and relieves itch and irritation for up to 12 hours
Outdoor Irritation Relief: Clinically proven to help provide instant itch relief for outdoor irritations like insect bites, poison ivy, poison oak, and sumac
Indoor Itch Relief: This skin ointment can also help to soothe and relieve itchiness from indoor causes like dry skin, skin rash, and psoriasis
Helps Heal the Itch: Formula features 1% hydrocortisone anti itch ointment, and is fragrance free, paraben free, and hypoallergenic
Includes one (1) 2 ounce tube of Aquaphor Itch Relief Ointment

Monistat Instant Itch Relief Cream for Women, Maximum Strength Feminine Itch Care, 1 oz, 2 Pack

Monistat Instant Itch Relief Cream for Women, Maximum Strength Feminine Itch Care, 1 oz, 2 Pack

Instant relief from intense itching.
Soothing and cooling sensation provided.
Hypoallergenic and fragrance-free formula.

Main Highlights

Instant Itch Relief Cream helps relieve intense vaginal itch fast
Maximum strength cream cools, relieves and soothes instantly
Provides long-lasting relief from intense vaginal itch
Fragrance free and hypoallergenic; contains 1% Hydrocortisone

Aquaphor Children's Itch Relief Ointment, 1% Hydrocortisone Anti Itch Ointment for Skin Irritation, Insect Bites, Psoriasis, Skin Rashes Eczema & Poison Ivy, Fragrance Free, 1 Oz Tube, Pack of 2

Aquaphor Children's Itch Relief Ointment, 1% Hydrocortisone Anti Itch Ointment for Skin Irritation, Insect Bites, Psoriasis, Skin Rashes Eczema & Poison Ivy, Fragrance Free, 1 Oz Tube, Pack of 2

Effective relief for children's itches.
Soothes outdoor irritation quickly.
Hypoallergenic and fragrance-free formula.

Main Highlights

CHILDREN'S ITCH RELIEF OINTMENT: Aquaphor Children's Itch Relief Ointment is suitable for children ages 2 and up
INSTANT RELIEF: Delivers up to 12 hours of significant itch relief and helps provide instant soothing itch relief for eczema flares, skin irritation, rashes and psoriasis
OUTDOOR IRRITATION RELIEF: Anti itch ointment can also be used to help soothe and relieve itchiness from outdoor causes such as insect bites and poison ivy
FORMULATED WITHOUT: Features 1% hydrocortisone anti-itch ointment and is fragrance free, paraben free, and hypoallergenic, making it ideal for children’s skin care
INCLUDES: Two 1 ounce tubes of Aquaphor Children's Itch Relief Ointment, 1% Hydrocortisone Anti-Itch Ointment

Eucerin Itch Relief Intensive Calming Body Lotion for Dry Itchy Skin, Unscented Lotion with Cooling Menthol and Ceramides, 8.4 Fl Oz Bottle

Eucerin Itch Relief Intensive Calming Body Lotion for Dry Itchy Skin, Unscented Lotion with Cooling Menthol and Ceramides, 8.4 Fl Oz Bottle

Instant itch relief for hours.
Enriched with skin-strengthening Ceramides.
Non-greasy and fragrance-free formula.

Main Highlights

12-Hour Relief: This Eucerin sensitive skin lotion immediately relieves and calms itchiness caused by dry skin for up to 12 hours
Formulated with Menthol: Eucerin lotion for itchy skin formulated with menthol to provide instant relief from the itch caused by dry skin
Soft and Smooth Skin: This body moisturizer is enriched with Ceramides to help strengthen the skin and leave it feeling soft and smooth
Free Of: This non-greasy unscented lotion is dye free, paraben free and absorbs quickly into skin
Includes one (1) 8.4 fluid ounce bottle of Eucerin Itch Relief Intensive Calming Body Lotion, Fragrance Free Lotion for Dry Itchy Skin

Curel Itch Defense Calming Body Lotion, Moisturizer for Dry, Itchy Skin, Body and Hand Lotion, with Advanced Ceramide Complex, Pro-Vitamin B5, Shea Butter, 20 Oz

Curel Itch Defense Calming Body Lotion, Moisturizer for Dry, Itchy Skin, Body and Hand Lotion, with Advanced Ceramide Complex, Pro-Vitamin B5, Shea Butter, 20 Oz

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Clinically proven relief from itching.
Restores skin's moisture barrier.
Soothes eczema-prone skin effectively.

Main Highlights

SAFE FOR MOST SKIN TYPES - Suitable for use on babies 6 months and up

Cortizone 10 Maximum Strength Anti-Itch Cream with Soothing Aloe, 1% Hydrocortisone Creme, 2 oz.

Cortizone 10 Maximum Strength Anti-Itch Cream with Soothing Aloe, 1% Hydrocortisone Creme, 2 oz.

5% OffFree Shipping

Fast relief for itchy skin.
Doctor-recommended for effectiveness.
Fragrance and dye-free formula.

Main Highlights

INCLUDES: One (1) 2 oz. tube of Cortizone-10 Maximum Strength* Soothing Aloe Itch Relief Cream (*Among topical anti-itch OTCs)
RELIEVES ITCH: Cortizone-10 helps relieve itch associated with minor skin irritations, inflammation, and rashes due to eczema, psoriasis, insect bites, seborrheic dermatitis, poison ivy, oak, sumac, and more
ACTIVE INGREDIENT: Formulated with 1% hydrocortisone for maximum-strength itch relief without a prescription
TRAVEL ESSENTIALS: The perfect addition to first aid kits, camping essentials and travel bags for anytime you need on-the-go relief
FAST ACTING: Relieves itch in five minutes with a fragrance-free and dye-free formula
DOCTOR RECOMMENDED: Cortizone-10 is the No. 1 doctor-recommended OTC anti-itch brand* and is suitable for adults and children ages 2+ (*2024 IQVIA Study)

Cortizone 10 Maximum Strength Intensive Moisture Anti-Itch Cream, 1% Hydrocortisone, 2 oz.

Cortizone 10 Maximum Strength Intensive Moisture Anti-Itch Cream, 1% Hydrocortisone, 2 oz.

6% OffFree Shipping

Fast itch relief for skin.
Nourishing ingredients for hydration.
Doctor-recommended effectiveness guaranteed.

Main Highlights

INCLUDES: One (1) 2 oz. tube of Cortizone-10 Maximum Strength* Intensive Healing Itch Relief Cream (*Among topical anti-itch OTCs)
RELIEVES ITCH: Cortizone-10 helps relieve itch associated with minor skin irritations, inflammation, and rashes due to eczema, psoriasis, insect bites, seborrheic dermatitis, poison ivy, oak, sumac, and more
MOISTURIZES & RESTORES: Includes 10 moisturizers, plus vitamins A, C, and E to nourish skin and help restore skin's moisture barrier
ACTIVE INGREDIENT: Formulated with 1% hydrocortisone for maximum-strength itch relief without a prescription
TRAVEL ESSENTIALS: The perfect addition to first aid kits, camping essentials and travel bags for anytime you need on-the-go relief
FAST ACTING: Relieves itch in five minutes with 24-hour moisture that's gentle on skin, fragrance free, and dye free
DOCTOR RECOMMENDED: Cortizone-10 is the No. 1 doctor-recommended OTC anti-itch brand* and is suitable for adults and children ages 2+ (*2024 IQVIA Study)