10 Best Gel Eye Drops For Dry Eyes Preservative Free of 2025

Last updated on 07/16/2025
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Best Choice
1
9.7
Exceptional
OPTASE MGD Advanced Dry Eye Drops - Preservative Free Drops for Dry Eyes and MGD - Lipid-Based Artificial Tears - Demet Technology, Multidose Bottle, Contact Lens Safe - .33 fl oz, 300 Doses
Optase
OPTASE MGD Advanced Dry Eye Drops - Preservative Free Drops for Dry Eyes and MGD - Lipid-Based Artificial Tears - Demet Technology, Multidose Bottle, Contact Lens Safe - .33 fl oz, 300 Doses
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Why We Love It
  • Innovative technology for clear relief.
  • Natural lipid for maximum comfort.
  • Convenient, preservative-free multi-use bottle.
Main Highlights
  • INNOVATIVE DEMET TECHNOLOGY: OPTASE MGD Advanced Eye Drops offers a superior lubricating eye drops in an optically clear, non-blurry formula for relief from moderate to severe symptoms of MGD
  • LIPID BASED DRY EYE RELIEF: The advanced formulation of OPTASE MGD eye drops utilizes Sacha Inchi seed oil, a high quality, natural lipid with a balanced Omega 3 and Omega 6 ratio for maximum comfort
  • EFFECTIVELY MANAGE MGD SYMPTOMS: With an innovative lipid solution, OPTASE MGD strengthens, protects, and hydrates the tear film to help soothe symptoms of MGD and evaporative lipid deficiency
  • ADVANCED BOTTLE TECHNOLOGY: The multi-use bottle of OPTASE MGD Advanced offers 300 drops, maintains sterility over 3 months, and is preservative free and contact lens safe for convenience on the go
  • COMPLETE DOCTOR RECOMMENDED EYE CARE RELIEF: OPTASE is the expert recommended 3-step regimen to help tackle the cause and symptoms of Dry Eyes, especially Meibomian Gland Dysfunction (MGD)
  • USE AS DIRECTED: Please note this product includes both a manufactured date and an expiration date. Always read the label, warnings, and instructions for use
9.7
Exceptional
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Best Value
2
9.6
Superb
TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)
TheraTears
TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)
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Why We Love It
  • Soothing overnight relief provided.
  • Natural electrolytes promote hydration.
  • Preservative-free for sensitive comfort.
Main Highlights
  • IMMEDIATE DRY EYE RELIEF: TheraTears Lubricating Liquid Gel Eye Drops provide immediate, long-lasting relief of dry eye symptoms
  • HYDRATING EYE DROPS: TheraTears Nighttime dry eye drops have 4X the lubrication* for a subtly thicker, extra hydrating experience for tired, dry eyes while you sleep; *vs. TheraTears Original
  • PRESERVATIVE FREE EYE DROPS: These eye drops for dry eyes are formulated with the 5 vital electrolytes found in natural tears and are individually sealed for preservative free eye drops in a single-use vial
  • CREATED BY AN OPHTHALMOLOGIST: TheraTears was created by an ophthalmologist after 18 years of research for a one-of-a-kind eye drop
  • DOCTOR RECOMMENDED: Doctor recommended and created to bring balance and hydration to dry eyes
9.6
Superb
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3
9.4
Superb
Save 39%
Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)
Systane
Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)
39% OffFree Shipping
Why We Love It
  • Fast hydration for dry eyes.
  • Preservative free for sensitive users.
  • Compatible with all contact lenses.
Main Highlights
  • Hydrates fast and provides long-lasting relief for dry eyes
  • Preservative free eye drops
  • Contains hyaluronate for advanced hydration
  • Safe for use with all contact lenses
  • Extra moisturizing eye drops for sensitive eyes
9.4
Superb
Save 39%
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4
9.3
Superb
Save 40%
Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)
Systane
Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)
40% OffFree Shipping
Why We Love It
  • Rapid relief for sensitive eyes.
  • Safe and preservative-free formula.
  • Advanced nano droplets enhance coverage.
Main Highlights
  • Fast acting hydration for sensitive eyes
  • Preservative free tear evaporation protection
  • Nano droplets for better coverage
9.3
Superb
Save 40%
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5
9.1
Superb
Save 37%
Systane Ultra Multi-Dose Preservative-Free Eye Drops Twin Pack (2x10ml)
Systane
Systane Ultra Multi-Dose Preservative-Free Eye Drops Twin Pack (2x10ml)
37% OffFree Shipping
Why We Love It
  • Fast-Acting Hydration for Relief.
  • Sensitive Eyes Receive Gentle Care.
  • Protection Against Tear Evaporation.
Main Highlights
  • Preservative-Free Lubricant Eye Drops
  • Fast-Acting Hydration and lasting dry eye relief
  • Moisture rich formula eye drops for sensitive eyes
  • Tear evaporation protection for high-performance dry eye symptom relief that lasts
9.1
Superb
Save 37%
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6
9.0
Superb
Save 35%
Refresh Celluvisc Lubricant Eye Gel Preservative-Free Tears, 0.01 fl oz (0.4 mL), 30 Single-Use Containers
Refresh
Refresh Celluvisc Lubricant Eye Gel Preservative-Free Tears, 0.01 fl oz (0.4 mL), 30 Single-Use Containers
35% OffFree Shipping
Why We Love It
  • Original strength formula works wonders.
  • Relieves dry eye discomfort quickly.
  • Trusted by doctors for decades.
Main Highlights
  • Original strength gel formula
  • Relieves dry, burning, irritated eyes
  • Alleviates discomfort
  • Keeps eyes feeling better longer
  • doctor recommended with over 30 years of experience. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey
9.0
Superb
Save 35%
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7
8.9
Excellent
Save 15%
Systane Lubricant Eye Gel Drops, 10-mL (Packaging May Vary)
Systane
Systane Lubricant Eye Gel Drops, 10-mL (Packaging May Vary)
15% OffFree Shipping
Why We Love It
  • Dr Recommended for eye care.
  • Thick protection for dry eyes.
  • Convenient drop, gel-like relief.
Main Highlights
  • #1 Dr Recommended Brand of Artificial Tears*
  • Thicker eye drop formulation that creates a protective shield over your eyes.
  • Convenience of a drop with a protection of a gel.
  • For the temporary relief of burning and irritation due to dryness of the eye
  • NOTE: PRODUCT PACKAGING MAY VARY
8.9
Excellent
Save 15%
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8
8.7
Excellent
Save 20%
iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary
iVIZIA
iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary
20% OffFree Shipping
Why We Love It
  • Thicker formula for overnight relief.
  • Hydrating polymers protect and moisturize.
  • Preservative-free for sensitive eyes.
Main Highlights
  • Your Dry Eyes Deserve Better: Thicker formula for overnight use, our gel provides more lubrication and moisture than our daytime formula and is ideal to relieve severe dry eye symptoms.
  • Free of Irritating Preservatives: Sterile, preservative-free, and can be used before or after eye surgery.
  • Sterile Single-Use Vials: iVIZIA Lubricant Eye Gel is offered in preservative-free sterile, single-use vials that are convenient and easy to use for severe dry eye or nighttime use.
  • iVIZIA – We See a Better Way: for healthy, comfortable eyelids
8.7
Excellent
Save 20%
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9
8.7
Excellent
Save 20%
Refresh Optive Gel Drops Lubricant Eye Gel For Dry Eyes, 0.33 Oz Sterile
Refresh
Refresh Optive Gel Drops Lubricant Eye Gel For Dry Eyes, 0.33 Oz Sterile
20% OffFree Shipping
Why We Love It
  • Extended relief for eye dryness.
  • Comprehensive gel formula for comfort.
  • Hydrocell technology ensures lasting hydration.
Main Highlights
  • Extended relief plus protection for dry, irritated eyes
  • Our most comprehensive gel formula
  • Anytime relief, day or night
  • Feels like a drop but works like a gel for lasting comfort
  • Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
  • #1 doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
8.7
Excellent
Save 20%
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10
8.7
Excellent
Save 11%
Refresh Liquigel Lubricant Eye Gel Drops, 0.5 Fl Oz Sterile
Refresh
Refresh Liquigel Lubricant Eye Gel Drops, 0.5 Fl Oz Sterile
11% OffFree Shipping
Why We Love It
  • Original strength gel formula.
  • Doctor recommended and trusted.
  • Long-lasting eye comfort relief.
Main Highlights
  • Original strength gel formula
  • Relieves dry, burning, irritated eyes
  • Alleviates discomfort
  • Keeps eyes feeling better longer
  • Doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey
  • For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun
8.7
Excellent
Save 11%
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