10 Best Eye Gel Drops For Dry Eyes Nighttime of 2025

Last updated on 07/16/2025
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Best Choice
1
9.7
Exceptional
TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)
TheraTears
TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)
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Why We Love It
  • Soothing overnight relief provided.
  • Natural electrolytes promote hydration.
  • Preservative-free for sensitive comfort.
Main Highlights
  • IMMEDIATE DRY EYE RELIEF: TheraTears Lubricating Liquid Gel Eye Drops provide immediate, long-lasting relief of dry eye symptoms
  • HYDRATING EYE DROPS: TheraTears Nighttime dry eye drops have 4X the lubrication* for a subtly thicker, extra hydrating experience for tired, dry eyes while you sleep; *vs. TheraTears Original
  • PRESERVATIVE FREE EYE DROPS: These eye drops for dry eyes are formulated with the 5 vital electrolytes found in natural tears and are individually sealed for preservative free eye drops in a single-use vial
  • CREATED BY AN OPHTHALMOLOGIST: TheraTears was created by an ophthalmologist after 18 years of research for a one-of-a-kind eye drop
  • DOCTOR RECOMMENDED: Doctor recommended and created to bring balance and hydration to dry eyes
9.7
Exceptional
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Best Value
2
9.6
Superb
Save 16%
Optase HYLO Night Eye Ointment - Preservative Free Lubricant & Nighttime Eye Ointment for Blepharitis and Stye - .18 oz
Optase
Optase HYLO Night Eye Ointment - Preservative Free Lubricant & Nighttime Eye Ointment for Blepharitis and Stye - .18 oz
16% OffFree Shipping
Why We Love It
  • Preservative free formula.
  • Long lasting overnight relief.
  • Gentle on sensitive skin.
Main Highlights
  • PRESERVATIVE FREE NIGHTTIME DRY EYE RELIEF: OPTASE HYLO Night Ointment offers soothing and comfortable lubrication to help resolve symptoms associated with Blepharitis, Dry Eye, and other eye problems
  • LONG LASTING OVERNIGHT PROTECTION: The well tolerated formula of OPTASE HYLO Night provides over 6 hours of physical retention for nighttime dry eye relief, without crusty, impaired morning vision
  • SAFE FOR EVERYDAY USE, 6 MONTH STABILITY: OPTASE HYLO Night Dry Eye Ointment is safe for continuous night time use. Simply apply once onto the eyelids before bed for overnight ocular lubrication
  • BALANCED FOR COMFORT: OPTASE HYLO Night is gentle and comfortable on the sensitive skin around the lids and lashes, without the irritation or gritty sensation found in other nighttime ointments
  • SUITABLE FOR ALL AGES: The preservative free, phosphate free protection of OPTASE HYLO Night Dry Eye Ointment is safe for children and adults, providing effective dry eye symptom relief for all ages
  • USE AS DIRECTED: The active ingredients White Petrolatum, Lanolin, and Light Mineral Oil relieves and protects from dry eye symptoms. Always read the label, warnings, and instructions for use
9.6
Superb
Save 16%
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3
9.4
Superb
Save 26%
GenTeal Tears Lubricant Eye Ointment, Night-Time Ointment, 0.12 Fl Oz (Pack of 3)
Genteal
GenTeal Tears Lubricant Eye Ointment, Night-Time Ointment, 0.12 Fl Oz (Pack of 3)
26% OffFree Shipping
Why We Love It
  • Provides effective dry eye relief.
  • Long-lasting comfort through the night.
  • Safe and preservative-free formula.
Main Highlights
  • Night-time dry eye relief
  • Concentrated ointment formula
  • Long lasting night-time comfort
  • Preservative & lanolin free
9.4
Superb
Save 26%
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4
9.2
Superb
Save 37%
OCuSOFT Retaine MGD Ophthalmic Emulsion - Complete Dry Eye Relief - Soothes Red & Irritated Eyes - 30 Count Preservative-Free Single-Use Containers - 0.01 Fl Oz
OCuSOFT
OCuSOFT Retaine MGD Ophthalmic Emulsion - Complete Dry Eye Relief - Soothes Red & Irritated Eyes - 30 Count Preservative-Free Single-Use Containers - 0.01 Fl Oz
37% OffFree Shipping
Why We Love It
  • Revolutionary preservative-free formula.
  • Long-lasting relief for dry eyes.
  • Advanced cationic oil technology.
Main Highlights
  • Retained mgd is a revolutionary preservative-free ophthalmic emulsion that moisturizes, lubricates and protects moderate to severe dry eyes
  • Provides long-lasting relief utilizing nova orb,
  • Proprietary cationic oil emulsion technology that effectively delivers ingredients through electrostatic attraction between positively charged droplets and the negatively charged ocular surface
  • Retained MGD is a revolutionary preservative-free ophthalmic emulsion that moisturizes, lubricates and protects moderate to severe dry eyes.
  • The hypo tonicity of the emulsion adds moisture by lowering the salt concentration of tears while the lipid component lubricates and protects the surface of the eye.
  • Retained MGD is a revolutionary preservative-free ophthalmic emulsion that moisturizes, lubricates and protects moderate to severe dry eyes.
  • Provides long-lasting relief utilizing Nova orb,
  • proprietary cationic oil emulsion technology that effectively delivers ingredients through electrostatic attraction between positively charged droplets and the negatively charged ocular surface.
  • The hypo tonicity of the emulsion adds moisture by lowering the salt concentration of tears while the lipid component lubricates and protects the surface of the eye.
9.2
Superb
Save 37%
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5
9.0
Superb
Systane Lubricant Eye Gel Drops 10 ml, 2 Count
Systane
Systane Lubricant Eye Gel Drops 10 ml, 2 Count
Free Shipping
Why We Love It
  • Convenient drop for easy use.
  • Gel-like protection for lasting safety.
  • Dual pack ensures anytime readiness.
Main Highlights
  • Convenience of a drop, protection of a gel
  • Pack of 2
  • Anytime protection
9.0
Superb
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6
8.9
Excellent
Save 15%
Systane Lubricant Eye Gel Drops, 10-mL (Packaging May Vary)
Systane
Systane Lubricant Eye Gel Drops, 10-mL (Packaging May Vary)
15% OffFree Shipping
Why We Love It
  • Dr Recommended for eye care.
  • Thick protection for dry eyes.
  • Convenient drop, gel-like relief.
Main Highlights
  • #1 Dr Recommended Brand of Artificial Tears*
  • Thicker eye drop formulation that creates a protective shield over your eyes.
  • Convenience of a drop with a protection of a gel.
  • For the temporary relief of burning and irritation due to dryness of the eye
  • NOTE: PRODUCT PACKAGING MAY VARY
8.9
Excellent
Save 15%
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7
8.7
Excellent
Save 9%
Systane Nighttime Lubricant Eye Ointment 3.5g Tube
Systane
Systane Nighttime Lubricant Eye Ointment 3.5g Tube
9% OffFree Shipping
Why We Love It
  • Doctor recommended for efficacy.
  • Nighttime relief for dry eyes.
  • Protective, preservative-free formula.
Main Highlights
  • #1 Dr Recommended Brand of Artificial Tears*
  • Provides nighttime relief of dry eye symptoms
  • Ointment soothes and protects against dry, irritated eyes
  • Forms long-lasting, protective layer on eyes while you sleep
  • Safe, preservative-free formula
8.7
Excellent
Save 9%
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8
8.7
Excellent
Save 20%
Refresh Optive Gel Drops Lubricant Eye Gel For Dry Eyes, 0.33 Oz Sterile
Refresh
Refresh Optive Gel Drops Lubricant Eye Gel For Dry Eyes, 0.33 Oz Sterile
20% OffFree Shipping
Why We Love It
  • Extended relief for eye dryness.
  • Comprehensive gel formula for comfort.
  • Hydrocell technology ensures lasting hydration.
Main Highlights
  • Extended relief plus protection for dry, irritated eyes
  • Our most comprehensive gel formula
  • Anytime relief, day or night
  • Feels like a drop but works like a gel for lasting comfort
  • Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
  • #1 doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
8.7
Excellent
Save 20%
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9
8.7
Excellent
Save 20%
iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary
iVIZIA
iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary
20% OffFree Shipping
Why We Love It
  • Thicker formula for overnight relief.
  • Hydrating polymers protect and moisturize.
  • Preservative-free for sensitive eyes.
Main Highlights
  • Your Dry Eyes Deserve Better: Thicker formula for overnight use, our gel provides more lubrication and moisture than our daytime formula and is ideal to relieve severe dry eye symptoms.
  • Free of Irritating Preservatives: Sterile, preservative-free, and can be used before or after eye surgery.
  • Sterile Single-Use Vials: iVIZIA Lubricant Eye Gel is offered in preservative-free sterile, single-use vials that are convenient and easy to use for severe dry eye or nighttime use.
  • iVIZIA – We See a Better Way: for healthy, comfortable eyelids
8.7
Excellent
Save 20%
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10
8.7
Excellent
Save 21%
Systane Lubricant Eye Gel, Nighttime, 0.35-Ounces (package may vary)
Systane
Systane Lubricant Eye Gel, Nighttime, 0.35-Ounces (package may vary)
21% OffFree Shipping
Why We Love It
  • Doctor recommended for trust.
  • Thick gel offers superior coverage.
  • Long-lasting relief while sleeping.
Main Highlights
  • Dr Recommended Brand of Artificial Tears
  • Thickest gel formulation to coat the eye with a strong layer of dry eye symptom protection.
  • Provides long-lasting, nighttime protection while you sleep.
  • For the temporary relief of burning and irritation due to dryness of the eye
8.7
Excellent
Save 21%
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