10 Best Eye Gel Drops For Dry Eyes Nighttime of 2025
Last updated on 09/15/2025
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Best Choice
1
Systane Nighttime Lubricant Eye Ointment 3.50 g , 0.12 Oz (Pack of 3)
Systane
21% OffFree Shipping
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Systane
Systane Nighttime Lubricant Eye Ointment 3.50 g , 0.12 Oz (Pack of 3)
21% OffFree Shipping
Why we love it
- Trusted brand for eye care.
- Cost-effective bulk purchasing option.
- Provides long-lasting moisture relief.
Main Highlights
- Brought to you by Systane
- Buy in bulk & save!
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Value for Money
2
Systane Lubricant Eye Gel Drops 10 ml, 2 Count
Systane
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Systane
Systane Lubricant Eye Gel Drops 10 ml, 2 Count
Free Shipping
Why we love it
- Convenient drop for easy use.
- Gel-like protection for lasting safety.
- Dual pack ensures anytime readiness.
Main Highlights
- Convenience of a drop, protection of a gel
- Pack of 2
- Anytime protection
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3
TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)
TheraTears
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TheraTears
TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)
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Why we love it
- Soothing overnight relief provided.
- Natural electrolytes promote hydration.
- Preservative-free for sensitive comfort.
Main Highlights
- Dry eye relief without preservatives: TheraTears nighttime lubricating eye drops in single-use vials provide soothing overnight relief from dry eye symptoms which may be better for people with sensitive eyes, with 4x the active lubricating ingredient of TheraTears original, no preservatives for sensitive eyes
- Instant hydration: TheraTears eye drops restore eyes’ natural balance and deliver hydration relief for dry eyes, because hydration is essential for eye health
- Electrolytes: TheraTears eye drops’ unique formula contains OxyLytes, the 5 vital electrolytes found in natural tears
- Created by an ophthalmologist: The TheraTears formula was created by an ophthalmologist, following 18 years of research, for a one-of-a-kind eye drop
- Doctor-recommended: TheraTears is a doctor-recommended brand (per ProVoice Survey data collected 9/1/23-8/31/24), created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details
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4
Soothe Eye Ointment by Bausch & Lomb, Lubricant Relief for Dry Eyes, Moisturizing & Comforting Nighttime Dry Eye Therapy, Suitable for Sensitive Eyes, Preservative Free, 3.5 g - 4 Pack
Bausch + Lomb
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Bausch + Lomb
Soothe Eye Ointment by Bausch & Lomb, Lubricant Relief for Dry Eyes, Moisturizing & Comforting Nighttime Dry Eye Therapy, Suitable for Sensitive Eyes, Preservative Free, 3.5 g - 4 Pack
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Why we love it
- Moisturizes dry eyes overnight.
- Gentle for sensitive eyes.
- Trusted eye care expertise.
Main Highlights
- EYE OINTMENT FOR DRY EYES AT NIGHT: Use Soothe Lubricant Eye Ointment to help moisturize & refresh severe dry eyes overnight for long-lasting relief & comfort. Soothing nighttime dry eye relief formula to help relieve dryness & prevent irritation
- SEVERE DRY EYE RELIEF: This dry eye ointment contains two lubricants to help relieve dry and irritated eye symptoms. Soothe ointment is gentle enough for sensitive eyes and can be used as often as needed, but stop use and ask a doctor if condition worsens or persists more than 72 hours. Remove contact lenses before using
- BAUSCH +LOMB EYE DROPS: Whether you have dry eyes, red eyes, itchy eyes, or all of the above, we offer a variety of options for your needs, including lubricating & preservative-free eye drops
- EYE CARE EXPERTS: For over 150 years, Bausch + Lomb has focused on innovation & quality in our eye care products, from contact lenses & solutions to eye drops, ointments, eye vitamins & more
- EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, & ointments to help make sure your eyes feel healthy, moisturized, & protected
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5
Refresh Liquigel Lubricant Eye Gel, 2 Bottles 0.5 Fl Oz (15mL) Each Sterile (30mL)
Refresh
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Refresh
Refresh Liquigel Lubricant Eye Gel, 2 Bottles 0.5 Fl Oz (15mL) Each Sterile (30mL)
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Why we love it
- Long-lasting dry eye relief.
- Soothing gel for comfort.
- Safe for contact lens users.
Main Highlights
- Long-lasting relief for dry eyes day or night
- Soothing gel formula
- Safe to use with contact lenses
- No shaking required prior to use, unlike Systane Gel Drops
- Value size - two convenient multi-dose bottle
- Safe to use as often as needed
- Inventiv Health Research and Insights Treatment Answers, MAT ending October 2016
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6
GenTeal Tears Lubricant Eye Ointment, Night-Time Ointment, 0.12 Fl Oz (Pack of 3)
Genteal
6% OffFree Shipping
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Genteal
GenTeal Tears Lubricant Eye Ointment, Night-Time Ointment, 0.12 Fl Oz (Pack of 3)
6% OffFree Shipping
Why we love it
- Provides effective dry eye relief.
- Long-lasting comfort through the night.
- Safe and preservative-free formula.
Main Highlights
- Night-time dry eye relief
- Concentrated ointment formula
- Long lasting night-time comfort
- Preservative & lanolin free
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7
Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers
Refresh
32% OffFree Shipping
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Refresh
Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers
32% OffFree Shipping
Why we love it
- Fast relief for dry eyes.
- Lasting comfort and protection.
- Convenient single-use vials available.
Main Highlights
- FAST-ACTING: Rapid relief to comfort dry, irritated eyes
- LASTING RELIEF: Soothes and prevents further irritation
- TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
- PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
- ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
- ON-THE-GO VIALS: 60 sterile single-use vials per carton that are easy and safe to use as often as needed
- TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
- FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan
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8
iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary
iVIZIA
8% OffFree Shipping
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iVIZIA
iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary
8% OffFree Shipping
Why we love it
- Thicker formula for overnight relief.
- Hydrating polymers protect and moisturize.
- Preservative-free for sensitive eyes.
Main Highlights
- Your Dry Eyes Deserve Better: Thicker formula for overnight use, our gel provides more lubrication and moisture than our daytime formula and is ideal to relieve severe dry eye symptoms.
- Free of Irritating Preservatives: Sterile, preservative-free, and can be used before or after eye surgery.
- Sterile Single-Use Vials: iVIZIA Lubricant Eye Gel is offered in preservative-free sterile, single-use vials that are convenient and easy to use for severe dry eye or nighttime use.
- IVIZIA – We See a Better Way: for healthy, comfortable eyelids
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9
Refresh Optive Gel Drops Lubricant Eye Gel For Dry Eyes, 0.33 Oz Sterile
Refresh
20% OffFree Shipping
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Refresh
Refresh Optive Gel Drops Lubricant Eye Gel For Dry Eyes, 0.33 Oz Sterile
20% OffFree Shipping
Why we love it
- Extended relief for eye dryness.
- Comprehensive gel formula for comfort.
- Hydrocell technology ensures lasting hydration.
Main Highlights
- Extended relief plus protection for dry, irritated eyes
- Our most comprehensive gel formula
- Anytime relief, day or night
- Feels like a drop but works like a gel for lasting comfort
- Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
- #1 doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
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10
Refresh Celluvisc Lubricant Eye Gel For Dry Eyes, Preservative-Free Drops, 0.01 Fl Oz Single-Use Containers, 30 Count
Refresh
32% OffFree Shipping
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Refresh
Refresh Celluvisc Lubricant Eye Gel For Dry Eyes, Preservative-Free Drops, 0.01 Fl Oz Single-Use Containers, 30 Count
32% OffFree Shipping
Why we love it
- Original strength formula works wonders.
- Relieves dry eye discomfort quickly.
- Trusted by doctors for decades.
Main Highlights
- Original strength gel formula
- Relieves dry, burning, irritated eyes
- Alleviates discomfort
- Keeps eyes feeling better longer
- #1 doctor recommended with over 30 years of experience.* *REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey
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