10 Best Eye Drops Preservative Free Gel of 2025

Last updated on 09/30/2025
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1
Refresh Celluvisc Lubricant Eye Gel Single-use Containers 30 Ea (Pack of 2)
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Refresh Celluvisc Lubricant Eye Gel Single-use Containers 30 Ea (Pack of 2)
Refresh
Free Shipping
Why we love it
  • Safe for frequent use.
  • Gentle on eyes.
  • Easy to incorporate daily.
Main Highlights
  • Safe to use as often as needed.
  • Remove contact lenses prior to use.
Show More
9.9
Exceptional
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9.9
Exceptional
Refresh
Refresh Celluvisc Lubricant Eye Gel Single-use Containers 30 Ea (Pack of 2)
Free Shipping
Why we love it
  • Safe for frequent use.
  • Gentle on eyes.
  • Easy to incorporate daily.
Main Highlights
  • Safe to use as often as needed.
  • Remove contact lenses prior to use.
Show More
Value for Money
2
Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)
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Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)
Systane
41% OffFree Shipping
Why we love it
  • Fast hydration for dry eyes.
  • Preservative free for sensitive users.
  • Compatible with all contact lenses.
Main Highlights
  • Hydrates fast and provides long-lasting relief for dry eyes
  • Preservative free eye drops
  • Contains hyaluronate for advanced hydration
  • Safe for use with all contact lenses
  • Extra moisturizing eye drops for sensitive eyes
Show More
9.7
Exceptional
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9.7
Exceptional
Systane
Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)
41% OffFree Shipping
Why we love it
  • Fast hydration for dry eyes.
  • Preservative free for sensitive users.
  • Compatible with all contact lenses.
Main Highlights
  • Hydrates fast and provides long-lasting relief for dry eyes
  • Preservative free eye drops
  • Contains hyaluronate for advanced hydration
  • Safe for use with all contact lenses
  • Extra moisturizing eye drops for sensitive eyes
Show More
3
TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)
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TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)
TheraTears
6% OffFree Shipping
Why we love it
  • Soothing overnight relief provided.
  • Natural electrolytes promote hydration.
  • Preservative-free for sensitive comfort.
Main Highlights
  • Dry eye relief without preservatives: TheraTears nighttime lubricating eye drops in single-use vials provide soothing overnight relief from dry eye symptoms which may be better for people with sensitive eyes, with 4x the active lubricating ingredient of TheraTears original, no preservatives for sensitive eyes
  • Instant hydration: TheraTears eye drops restore eyes’ natural balance and deliver hydration relief for dry eyes, because hydration is essential for eye health
  • Electrolytes: TheraTears eye drops’ unique formula contains OxyLytes, the 5 vital electrolytes found in natural tears
  • Created by an ophthalmologist: The TheraTears formula was created by an ophthalmologist, following 18 years of research, for a one-of-a-kind eye drop
  • Doctor-recommended: TheraTears is a doctor-recommended brand (per ProVoice Survey data collected 9/1/23-8/31/24), created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details
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9.6
Superb
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9.6
Superb
TheraTears
TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)
6% OffFree Shipping
Why we love it
  • Soothing overnight relief provided.
  • Natural electrolytes promote hydration.
  • Preservative-free for sensitive comfort.
Main Highlights
  • Dry eye relief without preservatives: TheraTears nighttime lubricating eye drops in single-use vials provide soothing overnight relief from dry eye symptoms which may be better for people with sensitive eyes, with 4x the active lubricating ingredient of TheraTears original, no preservatives for sensitive eyes
  • Instant hydration: TheraTears eye drops restore eyes’ natural balance and deliver hydration relief for dry eyes, because hydration is essential for eye health
  • Electrolytes: TheraTears eye drops’ unique formula contains OxyLytes, the 5 vital electrolytes found in natural tears
  • Created by an ophthalmologist: The TheraTears formula was created by an ophthalmologist, following 18 years of research, for a one-of-a-kind eye drop
  • Doctor-recommended: TheraTears is a doctor-recommended brand (per ProVoice Survey data collected 9/1/23-8/31/24), created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details
Show More
4
Systane Lubricant Eye Gel Drops 10 ml, 2 Count
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Systane Lubricant Eye Gel Drops 10 ml, 2 Count
Systane
Free Shipping
Why we love it
  • Convenient drop for easy use.
  • Gel-like protection for lasting safety.
  • Dual pack ensures anytime readiness.
Main Highlights
  • Convenience of a drop, protection of a gel
  • Pack of 2
  • Anytime protection
Show More
9.4
Superb
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9.4
Superb
Systane
Systane Lubricant Eye Gel Drops 10 ml, 2 Count
Free Shipping
Why we love it
  • Convenient drop for easy use.
  • Gel-like protection for lasting safety.
  • Dual pack ensures anytime readiness.
Main Highlights
  • Convenience of a drop, protection of a gel
  • Pack of 2
  • Anytime protection
Show More
5
Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)
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Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)
Systane
12% Off
Why we love it
  • Rapid relief for sensitive eyes.
  • Safe and preservative-free formula.
  • Advanced nano droplets enhance coverage.
Main Highlights
  • Fast acting hydration for sensitive eyes
  • Preservative free tear evaporation protection
  • Nano droplets for better coverage
Show More
9.3
Superb
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9.3
Superb
Systane
Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)
12% Off
Why we love it
  • Rapid relief for sensitive eyes.
  • Safe and preservative-free formula.
  • Advanced nano droplets enhance coverage.
Main Highlights
  • Fast acting hydration for sensitive eyes
  • Preservative free tear evaporation protection
  • Nano droplets for better coverage
Show More
6
Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers
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Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers
Refresh
40% OffFree Shipping
Why we love it
  • Fast relief for dry eyes.
  • Lasting comfort and protection.
  • Convenient single-use vials available.
Main Highlights
  • FAST-ACTING: Rapid relief to comfort dry, irritated eyes
  • LASTING RELIEF: Soothes and prevents further irritation
  • TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
  • PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
  • ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
  • ON-THE-GO VIALS: 60 sterile single-use vials per carton that are easy and safe to use as often as needed
  • TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
  • FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan
Show More
9.2
Superb
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9.2
Superb
Refresh
Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers
40% OffFree Shipping
Why we love it
  • Fast relief for dry eyes.
  • Lasting comfort and protection.
  • Convenient single-use vials available.
Main Highlights
  • FAST-ACTING: Rapid relief to comfort dry, irritated eyes
  • LASTING RELIEF: Soothes and prevents further irritation
  • TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
  • PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
  • ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
  • ON-THE-GO VIALS: 60 sterile single-use vials per carton that are easy and safe to use as often as needed
  • TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
  • FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan
Show More
7
Systane Nighttime Lubricant Eye Ointment 3.50 g (2 Pack) Lubricates and Comforts Dry Eyes Preservative-Free Rich Ointment for Nighttime Relief
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Systane Nighttime Lubricant Eye Ointment 3.50 g (2 Pack) Lubricates and Comforts Dry Eyes Preservative-Free Rich Ointment for Nighttime Relief
Systane
30% Off
Why we love it
  • Restores comfort while sleeping.
  • Long-lasting dry eye relief.
  • Safe, preservative-free formula.
Main Highlights
  • LUBRICANT OINTMENT: Help restore comfort and relieve dry eye while you sleep
  • FEATURES: Sterile gel drops deliver long-lasting relief of dry-eye symptoms with easy overnight use
  • EYE RELIEF: Long-lasting nighttime protection
  • FORMULATION: Unique combination of ingredients can help provide relief of symptoms brought on by windy conditions, sunny weather, and digital eye strain
  • DRY EYE THERAPY: Safe; Preservative-free formula
Show More
9.0
Superb
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9.0
Superb
Systane
Systane Nighttime Lubricant Eye Ointment 3.50 g (2 Pack) Lubricates and Comforts Dry Eyes Preservative-Free Rich Ointment for Nighttime Relief
30% Off
Why we love it
  • Restores comfort while sleeping.
  • Long-lasting dry eye relief.
  • Safe, preservative-free formula.
Main Highlights
  • LUBRICANT OINTMENT: Help restore comfort and relieve dry eye while you sleep
  • FEATURES: Sterile gel drops deliver long-lasting relief of dry-eye symptoms with easy overnight use
  • EYE RELIEF: Long-lasting nighttime protection
  • FORMULATION: Unique combination of ingredients can help provide relief of symptoms brought on by windy conditions, sunny weather, and digital eye strain
  • DRY EYE THERAPY: Safe; Preservative-free formula
Show More
8
Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 30 Single-Use Containers
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Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 30 Single-Use Containers
Refresh
18% OffFree Shipping
Why we love it
  • Rapid relief for dry eyes.
  • Soothes and prevents irritation.
  • Convenient single-use on-the-go vials.
Main Highlights
  • FAST-ACTING: Rapid relief to comfort dry, irritated eyes
  • LASTING RELIEF: Soothes and prevents further irritation
  • TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
  • PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
  • ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
  • ON-THE-GO VIALS: 30 sterile single-use vials per carton that are easy and safe to use as often as needed
  • TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
  • FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan
Show More
8.9
Excellent
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8.9
Excellent
Refresh
Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 30 Single-Use Containers
18% OffFree Shipping
Why we love it
  • Rapid relief for dry eyes.
  • Soothes and prevents irritation.
  • Convenient single-use on-the-go vials.
Main Highlights
  • FAST-ACTING: Rapid relief to comfort dry, irritated eyes
  • LASTING RELIEF: Soothes and prevents further irritation
  • TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
  • PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
  • ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
  • ON-THE-GO VIALS: 30 sterile single-use vials per carton that are easy and safe to use as often as needed
  • TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
  • FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan
Show More
9
Refresh Plus Lubricant Eye Drops For Dry Eyes, Preservative-Free,Value Size, 0.01 Fl Oz Single-Use Containers, 70 Count
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Refresh Plus Lubricant Eye Drops For Dry Eyes, Preservative-Free,Value Size, 0.01 Fl Oz Single-Use Containers, 70 Count
Refresh
30% OffFree Shipping
Why we love it
  • Preservative-free for sensitive eyes.
  • Instant relief from dryness.
  • Convenient single-use vials.
Main Highlights
  • Original strength, preservative-free formula
  • Relieves mild symptoms of eye dryness
  • Instantly moisturizes and lubricates
  • Designed to act like your own natural tears
  • Great for sensitive eyes
  • Value size. 70 on-the go, single-use vials
  • Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
  • The selling brand in preservative-free artificial tears. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
  • Active Ingredient: Carboxymethylcellulose Sodium (CMC) (0.5%); Inactive Ingredients: Calcium Chloride, Magnesium Chloride, Potassium Chloride, Purified Water, Sodium Chloride, and Sodium Lactate. May also Contain Hydrochloric Acid and/or Sodium Hydroxide to Adjust pH.
Show More
8.7
Excellent
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8.7
Excellent
Refresh
Refresh Plus Lubricant Eye Drops For Dry Eyes, Preservative-Free,Value Size, 0.01 Fl Oz Single-Use Containers, 70 Count
30% OffFree Shipping
Why we love it
  • Preservative-free for sensitive eyes.
  • Instant relief from dryness.
  • Convenient single-use vials.
Main Highlights
  • Original strength, preservative-free formula
  • Relieves mild symptoms of eye dryness
  • Instantly moisturizes and lubricates
  • Designed to act like your own natural tears
  • Great for sensitive eyes
  • Value size. 70 on-the go, single-use vials
  • Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
  • The selling brand in preservative-free artificial tears. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
  • Active Ingredient: Carboxymethylcellulose Sodium (CMC) (0.5%); Inactive Ingredients: Calcium Chloride, Magnesium Chloride, Potassium Chloride, Purified Water, Sodium Chloride, and Sodium Lactate. May also Contain Hydrochloric Acid and/or Sodium Hydroxide to Adjust pH.
Show More
10
Refresh Celluvisc Lubricant Eye Gel For Dry Eyes, Preservative-Free Drops, 0.01 Fl Oz Single-Use Containers, 30 Count
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Refresh Celluvisc Lubricant Eye Gel For Dry Eyes, Preservative-Free Drops, 0.01 Fl Oz Single-Use Containers, 30 Count
Refresh
31% OffFree Shipping
Why we love it
  • Original strength formula works wonders.
  • Relieves dry eye discomfort quickly.
  • Trusted by doctors for decades.
Main Highlights
  • Original strength gel formula
  • Relieves dry, burning, irritated eyes
  • Alleviates discomfort
  • Keeps eyes feeling better longer
  • #1 doctor recommended with over 30 years of experience.* *REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey
Show More
8.7
Excellent
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8.7
Excellent
Refresh
Refresh Celluvisc Lubricant Eye Gel For Dry Eyes, Preservative-Free Drops, 0.01 Fl Oz Single-Use Containers, 30 Count
31% OffFree Shipping
Why we love it
  • Original strength formula works wonders.
  • Relieves dry eye discomfort quickly.
  • Trusted by doctors for decades.
Main Highlights
  • Original strength gel formula
  • Relieves dry, burning, irritated eyes
  • Alleviates discomfort
  • Keeps eyes feeling better longer
  • #1 doctor recommended with over 30 years of experience.* *REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey
Show More