10 Best Eye Drops Preservative Free For Dry Eyes of 2025
Last updated on 09/07/2025
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Best Choice
1
Systane Ultra Lubricant Eye Drops, 60 Count (Pack of 1), (Packaging may vary)
Systane
20% OffFree Shipping
Systane
Systane Ultra Lubricant Eye Drops, 60 Count (Pack of 1), (Packaging may vary)
20% OffFree Shipping
Why We Love It
- Doctor Recommended for Trust.
- Extended Protection for Comfort.
- Quick Relief for Dry Eyes.
Main Highlights
- #1 Dr Recommended Brand of Artificial Tears*
- Extended Protection
- Fast Long-Lasting Dry Eye Symptom Relief
- Reduces both the signs and symptoms of dry eye
- Single-Use Convenience. Store at room temperature
Value for Money
2
Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers
Refresh
46% OffFree Shipping
Refresh
Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers
46% OffFree Shipping
Why We Love It
- Fast relief for dry eyes.
- Lasting comfort and protection.
- Convenient single-use vials available.
Main Highlights
- FAST-ACTING: Rapid relief to comfort dry, irritated eyes
- LASTING RELIEF: Soothes and prevents further irritation
- TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
- PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
- ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
- ON-THE-GO VIALS: 60 sterile single-use vials per carton that are easy and safe to use as often as needed
- TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
- FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan
3
Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)
Systane
33% OffFree Shipping
Systane
Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)
33% OffFree Shipping
Why We Love It
- Fast hydration for dry eyes.
- Preservative free for sensitive users.
- Compatible with all contact lenses.
Main Highlights
- Hydrates fast and provides long-lasting relief for dry eyes
- Preservative free eye drops
- Contains hyaluronate for advanced hydration
- Safe for use with all contact lenses
- Extra moisturizing eye drops for sensitive eyes
4
iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary
iVIZIA
8% OffFree Shipping
iVIZIA
iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary
8% OffFree Shipping
Why We Love It
- Thicker formula for overnight relief.
- Hydrating polymers protect and moisturize.
- Preservative-free for sensitive eyes.
Main Highlights
- Your Dry Eyes Deserve Better: Thicker formula for overnight use, our gel provides more lubrication and moisture than our daytime formula and is ideal to relieve severe dry eye symptoms.
- Free of Irritating Preservatives: Sterile, preservative-free, and can be used before or after eye surgery.
- Sterile Single-Use Vials: iVIZIA Lubricant Eye Gel is offered in preservative-free sterile, single-use vials that are convenient and easy to use for severe dry eye or nighttime use.
- IVIZIA – We See a Better Way: for healthy, comfortable eyelids
5
Systane Ultra Multi-Dose Preservative-Free Eye Drops Twin Pack (2x10ml)
Systane
32% OffFree Shipping
Systane
Systane Ultra Multi-Dose Preservative-Free Eye Drops Twin Pack (2x10ml)
32% OffFree Shipping
Why We Love It
- Fast-Acting Hydration for Relief.
- Sensitive Eyes Receive Gentle Care.
- Protection Against Tear Evaporation.
Main Highlights
- Preservative-Free Lubricant Eye Drops
- Fast-Acting Hydration and lasting dry eye relief
- Moisture rich formula eye drops for sensitive eyes
- Tear evaporation protection for high-performance dry eye symptom relief that lasts
6
Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)
Systane
Free Shipping
Systane
Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)
Free Shipping
Why We Love It
- Rapid relief for sensitive eyes.
- Safe and preservative-free formula.
- Advanced nano droplets enhance coverage.
Main Highlights
- Fast acting hydration for sensitive eyes
- Preservative free tear evaporation protection
- Nano droplets for better coverage
7
Systane PRO PF Multi-dose Preservative-Free Lubricant Eye Drops 2 Count
Systane
27% OffFree Shipping
Systane
Systane PRO PF Multi-dose Preservative-Free Lubricant Eye Drops 2 Count
27% OffFree Shipping
Why We Love It
- Triple-action relief for dry eyes.
- Hydrating formula supports long-lasting moisture.
- Gentle and preservative-free for sensitivity.
Main Highlights
- Triple-Action Dry Eye Relief: Systane Pro Preservative Free Eye Drops hydrate, restore and protect dry eyes for long-lasting relief
- Long-Lasting Hydration: Systane Pro Preservative Free lubricating eye drops are formulated with Hyaluronate, a moisturizer that occurs naturally in tears, to support extended hydrationfor all types of dry eye relief
- Tear Evaporation Protection: This unique formula enhanced with lipid nanodroplets helps lock in moisture and reduce tear evaporation
- Preservative-Free Formula: The gentle, preservative-free formula is ideal for sensitive eyes
- Trusted Brand: Systane is a trusted name in eye care, recommended by eye care professionals for its effective and reliable relief from dry eyes
- Convenient Size: The 10mL oz bottle is perfect for daily use, offering you triple action dry eye relief at your fingertips
- Contact Lens Friendly: safe for use with soft contact lenses
8
Refresh Optive Lubricant Eye Drops For Dry Eyes, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 60 Count
Refresh
28% OffFree Shipping
Refresh
Refresh Optive Lubricant Eye Drops For Dry Eyes, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 60 Count
28% OffFree Shipping
Why We Love It
- Lubricates and hydrates effectively.
- Relieves dryness quickly and efficiently.
- Perfect for sensitive eyes.
Main Highlights
- Dual-action formula lubricates and hydrates
- Relieves mild symptoms of eye dryness
- Works fast by delivering soothing moisture
- Preservative-free for sensitive eyes
- Value size: 60 on-the go, single-use vials
- Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
- The selling brand in preservative-free artificial tears; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
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Dry Eye Disease Treatment in the Year 2020
CreateSpace Independent Publishing Platform
Free Shipping
CreateSpace Independent Publishing Platform
Dry Eye Disease Treatment in the Year 2020
Free Shipping
10
Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count, Packaging May Vary
Refresh
27% OffFree Shipping
Refresh
Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count, Packaging May Vary
27% OffFree Shipping
Why We Love It
- Preservative-free for sensitive eyes.
- Instant moisture for dry eyes.
- Convenient single-use vials.
Main Highlights
- Original strength, preservative-free formula
- Relieves mild symptoms of eye dryness
- Instantly moisturizes and lubricates
- Designed to act like your own natural tears
- Great for sensitive eyes
- Value size. 50 on-the go, single-use vials
- Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
- The selling brand in preservative-free artificial tears. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.