10 Best Digestive Supplements of 2025

Last updated on 09/17/2025

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Emma Gut Health Doctors Endorsed Supplement - 60 Capsules - Relief from Gas and Bloating, Repairs Leaky Gut with Magnesium, Berberine, Vitamin D, Quercetin & More - Gut Health & Colon Cleanse Formula

Emma Gut Health Doctors Endorsed Supplement - 60 Capsules - Relief from Gas and Bloating, Repairs Leaky Gut with Magnesium, Berberine, Vitamin D, Quercetin & More - Gut Health & Colon Cleanse Formula

Improves digestion speed naturally.
Targets root causes effectively.
Promotes confidence and comfort.

Main Highlights

Back to Normal Bathroom Habits – This resveratrol supplement helps improve digestion speed. Reduce strain with this colon cleanser supplement.
Target the Root Cause - Why choose temporary solutions and risk long-term consequences? Reliance on probiotics, laxatives, and fiber can be detrimental. Trust a science-backed breakthrough instead.
Go Out with Confidence – Look your best and eat your favorite foods with this heartburn and gas relief supplement. Making the shedding of pounds easier. Flatten belly bloat, it's time for a new you!
Plenty of Benefits – Cleaning up your microbiome and digestive enzymes balance can help facilitate leaky gut repair and IBS relief. Helping with clearer skin, boosted metabolism, and more daytime energy.
Powerful Ingredients - Unlike laxatives for constipation, this thoughtfully crafted formula cuts no corners. Using only natural ingredients, these acid reflux supplements come with no compromise

Wholesome Wellness Digestive Enzymes 1000MG Plus Prebiotics & Probiotics Supplement, 180 Capsules, Organic Plant-Based Vegan Formula for Digestion & Lactose with Amylase & Bromelain,3-6 Months Supply

Wholesome Wellness

Wholesome Wellness Digestive Enzymes 1000MG Plus Prebiotics & Probiotics Supplement, 180 Capsules, Organic Plant-Based Vegan Formula for Digestion & Lactose with Amylase & Bromelain,3-6 Months Supply

46% OffFree Shipping

Powerful digestive enzyme blend.
Supports gut health effectively.
Made with organic ingredients.

Main Highlights

Get Digestive Comfort Now – Ultra Strength 1000 MG Dose of clinical grade digestive enzymes and a 10 billion CFU 10 strain probiotic with prebiotics. Get results & relief fast with more than double the dose of other digestive enzyme supplements. Using organic, systemic, Dr. formulated, & plant based ingredients to ensure the best healthy digestion for adult men & women. Anti bloating, flatulence, fat, pancreatic, & bowel cleansing with Turmeric, Ginger, Papaya, Pectin, Bladderwrack & more.
Goodbye Hard-to-Digest Foods – This formula features our Advanced Multi Enzyme System to help you digest fried, spicy, raw, processed food, dairy, protein, salts, carb / carbohydrate, vitamin and acidic diet fruits and veggies. Immune-Boosting Probiotic – The gut, biofilm & gallbladder is home to 50% of the body’s immune repair response and this supplement contains a powerful 10 billion CFU dose of 10 different probiotic strains clinically shown to enhance preventions & immune system response.
Relieve Gas, Belly Bloating / Bloat, Constipation, Leaky, Indigestion, Reflux, Belching & Acid Discomfort! Aid gut health, beauty & bloated stomach comfort. Prebiotic fiber, probiotic encapsulation(Lactobacillus acidophilus, plantarum, casei, salivarius, bulgaricus and Bifidobacterium lactis, bifidum, breve, longum), & enzymes support gut flora bacteria, bile, nutrient absorption, motility, & enzyme levels your body isn't producing as you age.
Complete digestive enzyme pills complex blend with essential organic blue agave heart, inulin, amylase / amilasa, papain, protease A, invertase, cellulase, hemicellulase, lactase, lipase / lipasa, alpha-galactosidase, fungal pepsin, glucomylase, & bromelina & bromelain supplement. Plus your probiotic supplement and prebiotic supplement (pre & pro) at the same time. All in a convenient purified cap / capsule form which you can open and take as a chewable with dietary nutrients, super food or meal
Proudly manufactured in the USA in a GMP-certified facility and third-party tested for purity and safety. This product is vegan, non-GMO, gluten-free, and free from soy, dairy, peanuts, eggs, shellfish, artificial sweeteners, colors, and flavors.

Designs for Health Digestzymes - Digestive Enzymes + Betaine Hydrochloride for Gas & Bloating Relief - Pepsin, Ox Bile, Lactase Enzyme & Lipase Enzymes for Digestion (60 Capsules)

Designs for Health

Designs for Health Digestzymes - Digestive Enzymes + Betaine Hydrochloride for Gas & Bloating Relief - Pepsin, Ox Bile, Lactase Enzyme & Lipase Enzymes for Digestion (60 Capsules)

Supports optimal nutrient absorption.
Relieves occasional gas and bloating.
Trusted by functional medicine professionals.

Main Highlights

Support Food Breakdown + Nutrient Absorption - This digestive enzyme supplement is a multi enzyme blend of a proprietary blend of digestive enzymes alongside hcl betaine with pepsin to support gut health and optimal digestion of proteins, fats, and carbohydrates.*
Occasional Gas or Bloating After Meals? Enzymes for digestion may be helpful for those experiencing occasional gas after eating, constipation, or a feeling of fullness after eating only a small quantity of food.* The use of Digestzyme before meals may offer occasional mild bloating relief. Take one digestion supplement capsule before meals to support digestive gut health.*
Pancreatic Enzymes + Betaine HCl - Protease DPP IV aids in the breakdown of casomorphin (from casein protein) and gluteomorphin (from gluten). Lactase enzyme helps break down the dairy sugar lactose, while lipase support fats and fat-soluble vitamins. The betaine hydrochloride supplement supports protein digestion and nutrient absorption.*
Why Add Bile Salts to Your Digestive Enzyme Blend? Ox bile provides bile acids, which are key to the digestion of fat and fat-soluble vitamins. Ox bile digestive enzymes formulas can offer further support for malabsorption and maldigestion, including fats.*
Clinically-Trusted Care - DFH is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals.**

Dr. Berg Advanced Digestive Enzymes with Apple Cider Vinegar - Includes Digestive Health Ingredients Like Betaine Hydrochloride (HCI), Ginger Root & Peppermint Leaf - 180 Capsules

Dr. Berg Nutritionals

Dr. Berg Advanced Digestive Enzymes with Apple Cider Vinegar - Includes Digestive Health Ingredients Like Betaine Hydrochloride (HCI), Ginger Root & Peppermint Leaf - 180 Capsules

Advanced digestive support formula.
GMP certified for quality assurance.
High-quality ingredients for effectiveness.

Main Highlights

𝗔𝗗𝗩𝗔𝗡𝗖𝗘𝗗 𝗗𝗜𝗚𝗘𝗦𝗧𝗜𝗩𝗘 𝗘𝗡𝗭𝗬𝗠𝗘𝗦 - This advanced digestion supplement contains 200mg Betaine Hydrochloride (HCI) and a proprietary blend that includes Apple Cider Vinegar (ACV), Ginger Root, Peppermint Leaf and more. Recommended usage is 2 capsules with meals. 90-day supply.
𝗨𝗦𝗔 𝗚𝗠𝗣 𝗖𝗘𝗥𝗧𝗜𝗙𝗜𝗘𝗗 𝗠𝗔𝗡𝗨𝗙𝗔𝗖𝗧𝗨𝗥𝗜𝗡𝗚 - Our state-of-the-art manufacturing facilities are located in the US and are staffed with highly trained individuals who formulate superior products. Being certified under US laws and regulations (GMP Certified), these facilities are uncompromising when it comes to cleanliness and quality control.
𝗜𝗡𝗖𝗥𝗘𝗗𝗜𝗕𝗟𝗘 𝗜𝗡𝗚𝗥𝗘𝗗𝗜𝗘𝗡𝗧𝗦 - We're sorry to say it, but if you’re looking for cheap, you’re in the wrong place. We search far and wide, domestic and international, to provide high-quality ingredients for which your body will thank you. Unfortunately, getting the best ingredients from domestic and international farms can come at a higher-than-normal cost. If quality, satisfaction, and results are essential to you, you’re in the right place!
𝗪𝗛𝗬 𝗪𝗘’𝗥𝗘 𝗗𝗜𝗙𝗙𝗘𝗥𝗘𝗡𝗧 - Also known as The Knowledge Doc, Dr. Berg has spent most of his life researching and providing natural solutions to everyday health problems. This extensive research and thousands of hours working with patients are what sets us apart from other brands, as it has allowed us to create proprietary blends you can’t get anywhere else.
𝟯𝟬-𝗗𝗔𝗬 𝗚𝘂𝗮𝗿𝗮𝗻𝘁𝗲𝗲 - If for any reason you're not happy with the results you experience within the first 30 days, we're happy to give you a full refund! Send us a message, and the refund will be processed as long as it's requested within 30 days of purchase.

Enzymedica Digest Gold + ATPro, Maximum Strength Digestive Enzymes, Helps Digest Large Meals for Instant Bloating Relief, 45 Count

Enzymedica Digest Gold + ATPro, Maximum Strength Digestive Enzymes, Helps Digest Large Meals for Instant Bloating Relief, 45 Count

Bloat relief for food lovers.
Boosts energy after meals.
Effective throughout the digestive system.

Main Highlights

For Food Lovers: Savor your favorite dishes worry-free; Our full-strength, bloat-busting digestive enzyme blend helps break down large meals faster, easing bloating and occasional indigestion for care-free indulgence*
ATPro Blend: Beat the post-meal blues and feel fueled with energy to power through your day; This unique formula features ATPro, a proprietary blend of ATP, Magnesium Citrate, Phytase and CoQ10 that helps fuel your body's cells*
Effective All the Way Through: Our proprietary Thera-blend enzymes are formulated for optimal activity throughout the digestive system's varying pH levels, providing faster relief and maximum digestive support*
Dosage: Just 1 capsule daily breaks down up to 34g fat, 16g protein and 86g carbs; Contains no gluten, milk, casein, soy, egg, artificial colors, flavors, or GMOs; Vegan, Kosher and Clean Label Project Certified
Making a Difference: Enzymedica products harness the power of the finest natural ingredients for maximum effectiveness; We create quality products without compromise while championing initiatives that support the well-being of people and our planet

Pure Encapsulations Digestive Enzymes Ultra - Vegetarian Digestive Enzyme Supplement to Support Protein, Carb, Fiber, and Dairy Digestion* - 90 Capsules

Pure Encapsulations

Pure Encapsulations Digestive Enzymes Ultra - Vegetarian Digestive Enzyme Supplement to Support Protein, Carb, Fiber, and Dairy Digestion* - 90 Capsules

Supports nutrient absorption effectively.
Aids digestion of complex foods.
Free from allergens and GMOs.

Main Highlights

Nutrient Absorption: Contains a mixture of vegetarian enzymes developed to support nutrient bioavailability and absorption; supports digestion*
Supports Digestion: Facilitates the normal breakdown of proteins, peptides, polysaccharides and disaccharides; assists with dairy, fiber, and protein digestion*
Digestive Enzymes: Offers a broad-spectrum combination of vegetarian digestive enzymes designed to provide optimal activity across a wide pH range
Dairy Enzyme Blend: This vegetarian enzyme blend supports digestion of dairy, sugar, lactose, and certain complex carbs; supports relief from occasional gas or bloating
Pure Difference: What we leave out matters, too; Pure Encapsulations products are free from common allergens, artificial or unnecessary ingredients, and GMOs

Metamucil, Fiber Capsules, 3-in-1 Psyllium Husk Fiber, 300 Capsules, Daily Fiber Supplement, Help support digestive health*, heart health by lowering cholesterol†, and healthy blood sugar levels*.

Metamucil, Fiber Capsules, 3-in-1 Psyllium Husk Fiber, 300 Capsules, Daily Fiber Supplement, Help support digestive health*, heart health by lowering cholesterol†, and healthy blood sugar levels*.

Promotes regularity and digestive health.
Only two simple ingredients.
Helps manage cholesterol levels.

Main Highlights

MULTIPLE HEALTH BENEFITS* in daily fiber capsules. Metamucil is the only leading fiber brand made with psyllium husk fiber
!
PSYLLIUM HUSK FIBER CAPSULES help support: digestive health*, heart health by lowering cholesterol, and healthy blood sugar levels*.
DAILY FIBER CAPSULES. Metamucil fiber capsules are designed for daily use. No spoon or mixing required!
PROMOTE DIGESTIVE HEALTH & REGULARITY*. Metamucil psyllium fiber capsules help trap and remove the waste*.
1 IN 10 AMERICANS GET ENOUGH FIBER from diet alone. Help close your fiber gap by taking Metamucil fiber capsules daily.
#1 DOCTOR RECOMMENDED fiber brand. Trusted for over 90 years.

Metamucil 4-in-1 Psyllium Husk Fiber Supplement, Sugar-Free, 180 teaspoons, Orange Flavored, Daily Fiber Powder for Digestive Health, made with Plant-Based Psyllium Husk Fiber

Metamucil 4-in-1 Psyllium Husk Fiber Supplement, Sugar-Free, 180 teaspoons, Orange Flavored, Daily Fiber Powder for Digestive Health, made with Plant-Based Psyllium Husk Fiber

Feel lighter and more energetic.
Promotes digestive health daily.
Supports healthy blood sugar levels.

Main Highlights

4 HEALTH BENEFITS, 1 DAILY FIBER. Metamucil is the only leading fiber brand made with psyllium husk fiber
for 4-in-1 health benefits!
PSYLLIUM HUSK FIBER helps support: digestive health*, heart health by lowering cholesterol, healthy blood sugar levels*, and appetite control*.
SUGAR-FREE fiber powder with refreshing orange flavor (not a low calorie food).
FEEL WHAT LIGHTER FEELS LIKE. Metamucil psyllium husk fiber helps promote regularity* so you can feel lighter and more energetic**.
1 IN 10 AMERICANS GET ENOUGH FIBER from diet alone. Help close your fiber gap by supplementing with Metamucil powders daily.
#1 DOCTOR RECOMMENDED fiber brand. Trusted for over 90 years.

NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules

NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules

55% OffFree Shipping

Supports healthy digestion efficiently.
Breaks down nutrients effectively.
GMP quality assures potency.

Main Highlights

SUPPORTS HEALTHY DIGESTION*: NOW Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion.* Take one capsule with a meal
BREAKS DOWN FATS, CARBS, AND PROTEINS*/OPTIMIZES NUTRIENT AVAILABILITY*: Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein*
CERTIFICATIONS/CLASSIFICATIONS: Soy Free, Made without Gluten, Keto Friendly
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation)
Packaged in the USA by a family owned and operated company since 1968

Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Meal Time Discomfort Relief & Bloating - Dual Action Approach - 60 CT

Physician's CHOICE

Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Meal Time Discomfort Relief & Bloating - Dual Action Approach - 60 CT

15% OffFree Shipping

Powerful digestive enzyme blend.
Promotes gut health naturally.
Third-party tested for quality.

Main Highlights

Beat the Bloat & Say Goodbye to Meal Time Discomfort: 16 beneficial enzymes that digest proteins, carbs, fruits, veggies, beans, dairy, & fats to cover all diets. With SBO Probiotics & Prebiotics to aid digestion further - Your New Meal Time Hack! Same great product you love, with a new look. Packaging May Vary!
Dual Action Relief: Our powerful digestive enzymes aid with breaking down food while the prebiotics & probiotics promote digestive function in the gut. They work synergistically to provide relief from mealtime discomfort. One Month Supply
Probiotics that Survive the Gut: Formulated with 3 soil-based probiotic strains - specifically selected due to their ability to survive the harsh gut environment. Along with Organic Prebiotics that fuel the growth of healthy bacteria in the gut.
Science Backed - Our Digestive Enzyme Probiotics are crafted based on scientific research. We have partnered with expert physicians to help review our products & research. We strive to educate & help you with informed decisions regarding your health.
Safety Assured Standard of Quality: Our Digestive Enzymes are 3rd-party tested for purity and potency. Each bottle is manufactured w/ love & care in the USA with strict quality control - using imported & domestic ingredients. No Refrigeration Needed