10 Best Digestive Nutritional Supplements of 2025

Last updated on 09/08/2025

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Seed DS-01 Daily Synbiotic - Prebiotic and Probiotic for Women & Men - Digestive Health, Gut Health, Immune Support, Bloating & Constipation Relief - Vegan & Shelf-Stable - 60 Capsules (30-Day Supply)

Seed DS-01 Daily Synbiotic - Prebiotic and Probiotic for Women & Men - Digestive Health, Gut Health, Immune Support, Bloating & Constipation Relief - Vegan & Shelf-Stable - 60 Capsules (30-Day Supply)

Clinically studied probiotic strains.
Whole-body health support benefits.
Patented delivery technology ensures efficacy.

Main Highlights

2-in-1 Prebiotic + Probiotic: Seed DS-01 Daily Synbiotic is formulated with 24 clinically and scientifically studied probiotic strains and a patented, plant-based prebiotic outer capsule to deliver benefits in and beyond the gut. 53.6 Billion AFU.
Whole-Body Benefits: In addition to bloating relief and improved regularity, DS-01 is formulated for digestive and whole-body benefits, including gut health, digestive health, gut barrier integrity, immune support, skin health, and hearth health.
Engineered to Survive: Seed’s patented capsule-in-capsule ViaCap delivery technology protects probiotics through digestion to ensure the full probiotic dose reaches the colon. DS-01 is shelf-stable and no refrigeration is required.
Getting Started: If it's your first time taking DS-01, or its been more than a week since your last dose, take 1 capsule daily for three days before moving on to 2 capsules daily. You may notice mild gastrointestinal discomfort or changes in digestion. Any discomfort typically resolves in 1-2 weeks.
Customer Support: DS-01 goes through extensive third party testing for safety and quality. If you have questions about DS-01, or aren't satisfied with your purchase, reach out to us directly and we'd be happy to help.

Physician's CHOICE Probiotics 60 Billion CFU - 10 Strains + Organic Prebiotics - Immune, Digestive & Gut Health - Supports Occasional Constipation, Diarrhea, Gas & Bloating - for Women & Men - 60ct

Physician's CHOICE

Physician's CHOICE Probiotics 60 Billion CFU - 10 Strains + Organic Prebiotics - Immune, Digestive & Gut Health - Supports Occasional Constipation, Diarrhea, Gas & Bloating - for Women & Men - 60ct

10% OffFree Shipping

Supports digestive and gut health.
Contains 10 probiotic strains.
Backed by scientific research.

Main Highlights

Max Strength General Probiotic 2 Month Supply (60ct) : Our probiotic is designed to support digestive health & gut health. A great choice for those looking to support a diverse healthy microbiome w/ 60B CFU - Probiotics for Women & Men alike. Same great product you love, with a new look. Packaging May Vary!
Support Your Gut: Our probiotic contains 10 diverse high-quality probiotic strains and organic prebiotics - synergistically working together to support your gut health. Expertly crafted to support occasional constipation, diarrhea, gas & bloating!
Survives the Gut: From start to finish - this probiotic is designed to survive the gut & maximize the colonization of our strains. We use a shelf-stable bottle, acid-resistant capsules, and 60 Billion Colony forming units (CFU) to achieve this!
Backed By Science - Our probiotics are crafted based on scientific research. We have partnered with a network of expert physicians to help review our products & research. We strive to educate & help you with informed decisions regarding your health.
Safety Assured Standard of Quality: Our 60B probiotic is 3rd-party tested for purity and potency. Each bottle is manufactured with love & care in the USA with strict quality control - using imported and domestic ingredients.

Culturelle Pro Strength Daily Probiotics For Digestive Health (2 Month Supply) with Prebiotics for Women & Men, Supports Occasional Diarrhea, Gas & Bloating, Gluten & Soy Free, 60 Count

Culturelle Pro Strength Daily Probiotics For Digestive Health (2 Month Supply) with Prebiotics for Women & Men, Supports Occasional Diarrhea, Gas & Bloating, Gluten & Soy Free, 60 Count

Supports digestive health naturally.
Proven effective probiotic strain.
No refrigeration needed for convenience.

Main Highlights

PROBIOTIC FOR DIGESTIVE HEALTH: Culturelle probiotics are naturally sourced with scientifically proven ingredients to keep your digestive system in balance; helps reduce occasional gas, bloating and diarrhea.* For daily use, take 1 capsule per day
PROVEN EFFECTIVE STRAIN: Culturelle Pro Strength Daily Probiotics for Men & Women are formulated with the clinically studied probiotic strain, Lactobacillus rhamnosus GG which has also been demonstrated to survive harsh stomach acids to get the probiotics where they’re needed in the intestines
PROBIOTIC POWER: Culturelle Pro Strength is formulated with 12 billion CFUs (colony-forming units) of the most clinically studied probiotic, proven to provide digestive & immune support, plus the prebiotic inulin*
SAFE & BACKED BY RESEARCH: Over 1,000 scientific studies and 30 years of research have demonstrated the safety and efficacy of Lactobacillus rhamnosus GG probiotic; Culturelle Pro Strength is vegetarian and contains no gluten, milk, soy or preservatives
NO REFRIGERATION REQUIRED: Every package of Culturelle Probiotics meets the highest standards for purity and potency when consumed; To preserve the billions of CFUs in your Culturelle Probiotics, store them in a cool, dry place away from sunlight

Florastor Probiotics for Digestive and Immune Health, 100 Capsules, Probiotics for Women & Men, Helps Flush Out Bad Bacteria, Boosts The Good with Our Unique Strain Saccharomyces Boulardii

Florastor Probiotics for Digestive and Immune Health, 100 Capsules, Probiotics for Women & Men, Helps Flush Out Bad Bacteria, Boosts The Good with Our Unique Strain Saccharomyces Boulardii

Supports digestive health effectively.
Unique strain backed by research.
Shelf stable and easy to use.

Main Highlights

Dual action support: Florastor probiotic helps strengthen digestive support; probiotics for women and men help flush bad bacteria and allow good bacteria to flourish; helps provide immune support and improve digestion by breaking down carbs and sugars*
Unique strain: These probiotic supplements contain 250mg of the exclusive probiotic strain Saccharomyces boulardii CNCM I-745 for overall gut health; this effective probiotic supplement strain has over 65 years of use and research*
Daily probiotics for digestive health: To build digestive health and support immunity, take 2 capsules 1-2 times daily*
Shelf stable: 3-year shelf life; no refrigeration required; exposure to heat or sunlight may lead to melting or damage to the product
The probiotics of choice: The number 1 selling probiotic in its class worldwide; Florastor formulas are made with ingredients that are vegetarian, gluten-free, titanium dioxide-free and appropriate for lactose intolerance

Micro Ingredients Mega Probiotics 200 Billion CFU, 120 Veggie Capsules | 40 Strains with Prebiotics & Probiotics Blend | Synbiotic & Enzyme Complex | Supports Gut & Digestive Health

Micro Ingredients

Micro Ingredients Mega Probiotics 200 Billion CFU, 120 Veggie Capsules | 40 Strains with Prebiotics & Probiotics Blend | Synbiotic & Enzyme Complex | Supports Gut & Digestive Health

High potency for optimal health.
Diverse strains for enhanced benefits.
Non-GMO and safe ingredients.

Main Highlights

Micro Ingredients offers maximum potency Mega Probiotic Veggie Capsules with 200 billion CFUs per serving. Features a diverse variety of 40 different strains for enhanced benefits.
120 potent vegetarian capsules per bottle. A powerful digestive complex with Bifidobacterium and Lactobacillus strains, as well as Chicory Inulin, Acacia Fiber, Amylase, Bromelain, and more.
An advanced formula combining probiotics, prebiotics, postbiotics, and enzymes. Supports gut microbiome balance, immune function, and overall digestion for both men and women.
Enjoy broad digestive support from multiple angles. Designed to help combat occasional gas and bloating while promoting a regular digestive process.
Premium non-GMO supplements. Made without soy, dairy, gluten, fish, shellfish, peanuts, and tree nuts. Ingredients must pass our 3rd party lab tests to ensure they’re safe, pure, and potent.

Wholesome Wellness Dr. Formulated Raw Probiotics for Women 100 Billion CFUs Capsules with Prebiotics, Digestive Enzymes, Approved for Adults, Shelf Stable Supplement

Wholesome Wellness

Wholesome Wellness Dr. Formulated Raw Probiotics for Women 100 Billion CFUs Capsules with Prebiotics, Digestive Enzymes, Approved for Adults, Shelf Stable Supplement

26% OffFree Shipping

Doctor-designed for optimal health.
High potency for effective support.
Convenient and easy to use.

Main Highlights

Doctor-Designed Probiotic Blend: Our unique blend features 34 doctor-selected strains from organic sources to support a healthy gut and feminine health.
100 Billion CFU per Serving: 100 Billion CFU per 2 Capsules: A high potency formula that delivers a powerful dose of beneficial bacteria to support digestive and immune health.
Digestive & Urinary Relief: With powerful probiotics, prebiotics, and cranberry extract for improved digestion, occasional constipation relief, and urinary tract support.
Organic Prebiotics & Enzymes: Contains Organic Prebiotics and Digestive Enzymes to aid nutrient absorption and gut health.
Quality & Free-From: Made in the USA at a GMP-certified facility with high-quality, non-GMO, vegan, and gluten-free ingredients. Free of soy, milk, egg, wheat, peanuts, shellfish, and artificial ingredients.
Shelf-Stable: Shelf-stable for convenient daily use with no refrigeration required.
Easy-to-Swallow Capsules: Convenient two-a-day capsules in a tasteless and odorless shell.

Benefiber Daily Prebiotic Fiber Supplement Powder for Digestive Health, Unflavored - 125 Servings (17.6 Ounces)

Benefiber Daily Prebiotic Fiber Supplement Powder for Digestive Health, Unflavored - 125 Servings (17.6 Ounces)

9% OffFree Shipping

Supports overall gut health.
Easily mixes into foods.
Gluten-free and sugar-free.

Main Highlights

One 17.6-ounce bottle of unflavored Benefiber Daily Prebiotic Fiber Supplement Powder for Digestive Health (1)
Prebiotic fiber supplement designed to help support gut health (1)
Daily fiber powder that strengthens and nourishes good bacteria to support gut health (1) using wheat dextrin
Unflavored fiber powder that dissolves clear and completely, allowing you to mix it into your favorite foods and non-carbonated beverages (3)
Gluten-free, sugar-free, grit-free dietary prebiotic fiber supplement made with wheat dextrin and no artificial flavors (2)
Stir two teaspoons into four to eight ounces of a non-carbonated beverage or soft food three times daily, for ages 12 years and older
Use one teaspoon three times daily, for ages 6 years to 11 years

HUM Flatter Me Digestive Enzymes for Women & Men, Digestive Health Bloating Supplement with Ginger & Peppermint Leaf, Fast Acting Anti Bloat Pills Multi Enzyme for Debloating, Vegan, 60 Capsules

HUM Flatter Me Digestive Enzymes for Women & Men, Digestive Health Bloating Supplement with Ginger & Peppermint Leaf, Fast Acting Anti Bloat Pills Multi Enzyme for Debloating, Vegan, 60 Capsules

Fast relief from bloating.
Supports healthy digestion naturally.
Clinically tested for effective results.

Main Highlights

FAST-ACTING, 30 MINUTE DEBLOAT FORMULA: Support digestion and help with bloating with our blend of 18 full-spectrum digestive enzymes like lipase, amylase, and bromelain. These enzymes are designed to assist in breaking down proteins, carbs, fats, and fiber, promoting digestive health and providing support from bloating for women and men.
NATURAL TRIPLE HERB BLEND FOR DIGESTION SUPPORT: Our fast-acting formula is enhanced with a natural triple herb blend of ginger, peppermint, and fennel to support healthy digestion for women and men, and help with nutrient absorption, so you feel your best after every meal.*
CLINICALLY TESTED RESULTS YOU CAN FEEL: Flatter Me’s advanced digestive enzymes for men and women has been shown to reduce bloating by up to 2 inches, so you can see and feel the difference.*
CLEAN AND CLINICALLY STUDIED: HUM products are Clean Label Project Certified, non-GMO, and rigorously tested to meet the highest standards of safety and quality. Free from artificial flavors, sweeteners, and colors, you can trust the purity and effectiveness of Flatter Me.*
HOW TO TAKE: Take one capsule with a meal for fast-acting bloating support anytime of the day. Simple and easy to use, Flatter Me is your go-to solution for digestive support anytime you need it.*

Align Probiotics, Probiotic Supplement for Daily Digestive Health, 28 capsules, #1 Recommended Probiotic by Gastroenterologists (Packaging May Vary)

Align Probiotics, Probiotic Supplement for Daily Digestive Health, 28 capsules, #1 Recommended Probiotic by Gastroenterologists (Packaging May Vary)

46% OffFree Shipping

24/7 digestive support available.
Recommended by top gastroenterologists.
Patented strain backed by research.

Main Highlights

24/7 DIGESTIVE SUPPORT. Align Probiotic Supplement, for men and women, naturally helps with occasional abdominal discomfort, gas, and bloating. One capsule a day, taken with or without food, helps to maintain your digestive system’s natural balance
#1 GASTROENTEROLOGIST RECOMMENDED PROBIOTIC for 10 years in a row. Align Probiotic is recommended more often by Gastroenterologists and Doctors than any other probiotics brand
EFFECTIVE & PATENTED STRAIN discovered by Gastroenterologists and backed by >15 yrs of research. Only Align contains the patented probiotic strain, Bifidobacterium 35624, which works naturally to supplement your digestive system with good bacteria
Align Probiotic Supplement is heat-foil seal wrapped to ensure survivability, and each lot is DNA tested to ensure effective levels of Bifidobacterium 35624
THERE’S MORE TO PROBIOTICS THAN JUST BILLIONS OF CFUs. Align is formulated with high quality ingredients and contains an effective level of CFUs and live cultures. Align Probiotics are gluten free, soy-free, vegetarian, and no refrigeration is required

Align Dualbiotic, Prebiotics and Probiotics for Women and Men, Probiotics for Digestive Health, Prebiotics Help Nourish Good Bacteria, Natural Fruit Flavors, 60 Probiotic Gummies

Align Dualbiotic, Prebiotics and Probiotics for Women and Men, Probiotics for Digestive Health, Prebiotics Help Nourish Good Bacteria, Natural Fruit Flavors, 60 Probiotic Gummies

20% OffFree Shipping

Recommended by top physicians.
Delicious and easy to take.
Low sugar and gluten-free.

Main Highlights

THE PROBIOTIC PHYSICIANS RECOMMEND MOST: Align Probiotic is the #1 probiotic brand recommended by Gastroenterologists for over 14 years running due to its unique strain. Align Probiotic is nearly 2x more recommended than any other probiotic brand
DUAL BENEFIT OF PREBIOTICS + PROBIOTICS: Align Gummies contain a prebiotic fiber, Inulin, to help nourish good bacteria in your digestive system. They also contain the probiotic, Bacillus Coagulans, which adds more good bacteria in your gut
GREAT-TASTING AND CONVENIENT: Align Prebiotic + Probiotic Gummies taste great, are easy to chew, and don’t require water to take. They’re the good-for-you supplement that you’ll actually look forward to taking
NATURAL FRUIT FLAVORS AND 1G OF SUGAR: Some gummies claim to support your health, but are loaded with sugars and artificial colors. Align Gummies are naturally flavored and contain 1g of beet sugar per serving, gluten-free, do not require refrigeration
THERE’S MORE TO PROBIOTICS THAN JUST MORE CFUs. Align Prebiotic + Probiotic Gummies contain 1 Billion CFUs – the effective dosage of our probiotic strain to support your digestive health