10 Best Eye Drops For Very Dry Eyes Contact Lenses of 2025

Last updated on 07/16/2025

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Optase Dry Eye Intense Drops, Single Dose - Preservative Free Drops for Long Lasting Relief - Artificial Tears to Relieve Severe Dry Eye Symptoms - 30 Single Dose Vials

Optase Dry Eye Intense Drops, Single Dose - Preservative Free Drops for Long Lasting Relief - Artificial Tears to Relieve Severe Dry Eye Symptoms - 30 Single Dose Vials

Moisturizes and protects eyes.
Preservative free formulation available.
Convenient single-dose vials.

Main Highlights

MOISTURIZE AND PROTECT: Made of glycerin and quality ingredients, OPTASE Dry Eye Intense Drops mix with the natural oils needed to protect your tears and hydrate your eyes to improve tear quality
PRESERVATIVE FREE: OPTASE Intense Eye Drops is the only product of its kind to provide a preservative free combination of ingredients designed to treat dry eye patients in a unique multi-dose bottle
MODERATE TO SEVERE DRY EYE RELIEF: The long lasting formulation of OPTASE Intense provides comfort for dry eye and post operative patients. And it is contact lens safe, providing relief when needed
CONVENIENT ON THE GO RELIEF: 30 convenient single-dose vials provide efficient on the go lubricating eye drops for fast dry eye relief
COMPLETE DOCTOR RECOMMENDED EYE CARE RELIEF: OPTASE is the expert recommended 3-step regimen to help tackle the cause and symptoms of Dry Eyes, Blepharitis and Meibomian Gland Dysfunction (MGD)

Systane Ultra Lubricant Eye Drops, Artificial Tears for Dry Eye, Twin Pack, 10-mL Each

Systane Ultra Lubricant Eye Drops, Artificial Tears for Dry Eye, Twin Pack, 10-mL Each

41% OffFree Shipping

Doctor Recommended for Trustworthiness.
Provides Extended Eye Relief.
Convenient for On-the-Go Use.

Main Highlights

#1 Dr Recommended Brand of Artificial Tears*, packaging may vary
Extended Protection
Fast Long-Lasting Dry Eye Symptom Relief.Store at room temperature
Reduces both the signs and symptoms of dry eye
Quickly soothe irritated eyes wherever you are

OPTASE HYLO Relief Dry Eye Drops - Fast-Acting Preservative Free Drops with Patented HYLO Delivery System - Artificial Tears for Mild to Moderate Dry Eye Relief - .33 Oz, 300 Doses

OPTASE HYLO Relief Dry Eye Drops - Fast-Acting Preservative Free Drops with Patented HYLO Delivery System - Artificial Tears for Mild to Moderate Dry Eye Relief - .33 Oz, 300 Doses

Preservative and phosphate free.
No wasted eye drops.
Contact lens safe formula.

Main Highlights

PRESERVATIVE AND PHOSPHATE FREE FORMULA - Made with moisturizing hyaluronic acid and glycerin, OPTASE HYLO Relief uses a phosphate and preservative free artificial tears formula for dry eye relief
NO WASTED EYE DROPS - The innovative, one-click, multi-use bottle of OPTASE HYLO Relief dry eyes eye drops provides 300 calibrated doses, while maintaining sterility for 6 months after opening
MILD TO MODERATE DRY EYE RELIEF - OPTASE HYLO Relief drops provides comfortable relief from mild to moderate dry eye symptoms. Plus, it is contact lens safe for convenient use throughout the day
INNOVATIVE BOTTLE DESIGN – OPTASE HYLO Relief’s unique bottle technology releases one drop of lubricating eye drops with just a press, with no waste – simply grip, position, and click
PAIR WITH OPTASE HYLO NIGHT – For optimal results, use OPTASE HYLO Relief moisturizing eye drops with OPTASE HYLO Relief Nighttime Eye Gel as part of the complete line of expert dry eye relief

Biotrue Hydration Boost, Preservative-Free Eye Drops for Dry Eyes, Instantly Moisturizes, Clears and Rehydrates, Contact Lens Friendly, Refresh & Relieve Eye Irritation, 0.33 FL Oz (Pack of 1)

Biotrue Hydration Boost, Preservative-Free Eye Drops for Dry Eyes, Instantly Moisturizes, Clears and Rehydrates, Contact Lens Friendly, Refresh & Relieve Eye Irritation, 0.33 FL Oz (Pack of 1)

Naturally inspired hydrating ingredients.
Instant relief for dry eyes.
Preservative-free for enhanced comfort.

Main Highlights

NATURALLY INSPIRED INGREDIENTS: Biotrue Hydration Boost Eye Drops are enhanced with HA (Hyaluronan), Antioxidant, and Electrolyte and provide instant moisture for dry eyes.
INSTANT MOISTURE: For dry, irritated eyes due to screen and environmental stressors.
Special preservative free, multi-dose bottle.
BIOTRUE EYE DROPS: Not only are the Hydration Boost Eye Drops free of preservatives but they are also pH balanced for comfort.
EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solutions to eye drops, vitamins, & ointments to help your eyes feel moisturized and protected.

Biotrue Hydration Boost for Contacts, Rehydrating Eye Drops for Dry Eyes, Preservative Free, Refreshes, Lubricates & Moisturizes Lenses, Rewetting Eye Drops, 0.33 FL Oz (Pack of 1)

Biotrue Hydration Boost for Contacts, Rehydrating Eye Drops for Dry Eyes, Preservative Free, Refreshes, Lubricates & Moisturizes Lenses, Rewetting Eye Drops, 0.33 FL Oz (Pack of 1)

Naturally inspired ingredients enhance comfort.
Lasting moisture keeps eyes hydrated.
Preservative-free for optimal safety.

Main Highlights

NATURALLY INSPIRED INGREDIENTS: Biotrue Hydration Boost for Contacts are enhanced with HA (Hyaluronan), Antioxidant (Protects HA from free radicals), and Electrolyte.
LASTING MOISTURE: For up to 8 hours of moisture (based on a laboratory study) and to help prevent deposit buildup.
REWETTING DROPS FOR CONTACT LENSES: Biotrue Hydration Boost for Contacts are the first preservative free multi-dose contact lens drops.
BIOTRUE CONTACT LENS DROPS: Not only are Biotrue Hydration Boost for Contacts free of preservatives but they are also pH balanced for comfort.
EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solutions to eye drops, vitamins, & ointments to help your contacts and eyes feel moisturized and protected.

REFRESH Contacts Contact Lens Comfort Moisture Drops 0.40 oz (Pack of 2)

REFRESH Contacts Contact Lens Comfort Moisture Drops 0.40 oz (Pack of 2)

28% OffFree Shipping

Lubricates and rehydrates lenses.
Doctor recommended for effectiveness.
Relieves dryness from contact lenses.

Main Highlights

May also be used to lubricate and rewet soft and rigid gas permeable (RGP) contact lenses and to cushion lenses prior to application
Silicone acrylate and fluorosilicone acrylate rigid gas permeable lenses are recommended for use with REFRESH CONTACTS. Consult your eye care practitioner to identify the lens you wear.
#1 doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
Relieves mild symptoms of eye dryness due to contact lens wear

Blink Boost Preservative-Free Lubricating Eye Drops, Eye Care Drops for Dry Eyes, Instant Moisture for Dry Irritated Eyes & Comfort Throughout the Day, Contact Lens Friendly, 10 mL

Blink Boost Preservative-Free Lubricating Eye Drops, Eye Care Drops for Dry Eyes, Instant Moisture for Dry Irritated Eyes & Comfort Throughout the Day, Contact Lens Friendly, 10 mL

Preservative-free for gentle relief.
Long-lasting hydration throughout the day.
Trusted brand for eye care.

Main Highlights

Preservative-Free Formula: Blink Boost Lubricating Eye Drops provide fast-acting relief from dryness and discomfort. The preservative-free formula is pH balanced to mimic natural tears, offering extra hydration and helps relieve dry eyes
Advanced Long-Lasting Hydration: Infused with hyaluronan, an electrolyte, and an antioxidant, these dry eyes eye drops enhance moisture retention while relieving discomfort from irritants like wind or sun, & provides comfort throughout the day
Gentle on Eyes: These lubricant eye drops for dry eyes soothe dryness & irritation without preservatives. Whether indoors or outdoors, they help keep your eyes comfortable & include HA and an electrolyte, found naturally in tears
Trusted Brand: There is a range of Blink products to meet your eye care needs, from dry eye drops to lock in moisture to preservative-free formulas. Blink products provide comfort, hydration, and relief from dry eyes
Reduce Everyday Discomfort: Blink eye drops are for the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun. The drops are also contact lens friendly.

BLINK Tears Lubricating Eye Drops, Moisturizing & Soothing for Mild to Moderate Dry Eyes, with Hyaluronate, Reduces Discomfort, Long-Lasting Hydration, Soothes & Moisturizes, 1 Fl Oz

BLINK Tears Lubricating Eye Drops, Moisturizing & Soothing for Mild to Moderate Dry Eyes, with Hyaluronate, Reduces Discomfort, Long-Lasting Hydration, Soothes & Moisturizes, 1 Fl Oz

38% OffFree Shipping

Instant relief for dry eyes.
Long-lasting hydration and comfort.
Trusted brand for eye care.

Main Highlights

Relief with Every Blink: Experience immediate and long-lasting dry eye symptom relief with Blink Tears Lubricating Eye Drops. These moisturizing eye drops instantly soothe & hydrate, restoring your tears natural salt balance and maximizing hydration
Hydration Boost with Hyaluronate: Our lubricating eye drops for dry eyes instantly moisturize mild to moderate dry eyes. The unique formula of the eye drop quickly thickens and stabilizes your tear film
Moisture Hold: Blink eye drops are formulated to stay in the eye for long-lasting dryness relief. These lubricant eye drops maximize hydration and provide comfort
Reduce Everyday Discomfort: These drops provide lubrication and hydration to the surface of the eye, keeping the eye moist
Trusted Brand: Blink has a range of products to meet your eye and contact lens care needs, from drops for dry eyes to lock in moisture, to preservative-free formulas; and contact lens drops to keep your contacts clean and hydrated. Blink products provide comfort and hydration, to help your eyes feel moisturized & protected

Refresh Optive Gel Drops Lubricant Eye Gel For Dry Eyes, 0.33 Oz Sterile

Refresh Optive Gel Drops Lubricant Eye Gel For Dry Eyes, 0.33 Oz Sterile

20% OffFree Shipping

Extended relief for eye dryness.
Comprehensive gel formula for comfort.
Hydrocell technology ensures lasting hydration.

Main Highlights

Extended relief plus protection for dry, irritated eyes
Our most comprehensive gel formula
Anytime relief, day or night
Feels like a drop but works like a gel for lasting comfort
Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
#1 doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

Refresh RELIEVA FOR CONTACTS Lubricant Eye Drops For Use with Contact Lenses, 0.27 fl oz (8 mL)

Refresh RELIEVA FOR CONTACTS Lubricant Eye Drops For Use with Contact Lenses, 0.27 fl oz (8 mL)

22% OffFree Shipping

Innovative formula for contact lens.
Relieves discomfort and dryness effectively.
Compatible with all contact lenses.

Main Highlights

Innovative formula specially designed for contact lens wearers
Relieves mild to moderate symptoms of eye dryness, irritation, and discomfort associated with contact lens wear
Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
You may keep your contacts in upon application
May also be used to lubricate and rewet soft and rigid gas permeable (RGP) contact lenses and to cushion lenses prior to application